Yıl: 2021 Cilt: 27 Sayı: 1 Sayfa Aralığı: 11 - 16 Metin Dili: İngilizce DOI: 10.21613/GORM.2021.1176 İndeks Tarihi: 20-06-2021

Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center

Öz:
OBJECTIVES: Suppressed immune system and physiological changes in pregnancy put pregnantwomen vulnerable to various viral diseases. Various studies have reported adverse pregnancy outcomes in SARS-CoV-2 infection. This study aimed to evaluate the maternal and fetal outcomes inSARS-CoV-2 affected pregnancies at our set up.STUDY DESIGN: It was a prospective cohort study conducted at a tertiary care Army Hospital, India.The first 50 cases of SARS CoV-2 positive pregnant women and 144 suspected cases that were foundSARS-CoV-2 negative, received and managed at separate set up, during a period extending from 01April 2020 to 15 Sep 2020 were included in our study. Their obstetric and neonatal outcomes along withthe demographic and other clinical data were compared.RESULTS: Total RT-PCR positivity rate of SARS-CoV-2 infection in pregnant women was 2.7%. 96%of our patients were asymptomatic for SARS-CoV-2 infection. Premature rupture of membrane, pretermdelivery, and Neonatal intensive care unit admission was similar in both groups. There were increasedincidences (70%) of cesarean section in SARS-CoV-2 positive pregnant women.CONCLUSION: The study reported comparable maternal and fetal outcomes in SARS-CoV 2 positivepregnant women when compared with SARS-CoV-2 negative pregnant women
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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Wu Z. McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA. 2020;323(13):1239-42. doi: 10.1001/jama. 2020.2648.
  • 2. Longman RE. Johnson TR. Viral respiratory disease in pregnancy. Curr Opin Obstet Gynecol. 2007;19(2):120-5. doi: 10.1097/GCO.0b013e328028fdc7.
  • 3. Pazos M. Sperling RS. Moran TM. Kraus TA. The influence of pregnancy on systemic immunity. Immunologic Research 2012;54(1-3):254-61. doi: 10.1007/s12026-012- 8303-9.
  • 4. Jamieson DJ. Honein MA. Rasmussen SA. Williams JL. Swerdlow DL. Biggerstaff MS. et al. H1N1 2009 influenza virus infection during pregnancy in the USA. 2009;374(9688):451-8. doi:10.1016/S0140-6736(09) 61304-0.
  • 5. Rasmussen SA. Smulian JC. Lednicky JA. Wen TS. Jamieson DJ. Coronavirus disease 2019 (COVID-19) and pregnancy: what obstetricians need to know. Am J Obstet Gynecol. 2020;222(5):415-26. doi: 10.1016/j.ajog.2020. 02.017.
  • 6. Schwartz DA. Graham AL. Potential maternal and infant outcomes from (Wuhan) coronavirus 2019-ncov infecting pregnant women: lessons from SARS, MERS, and other human coronavirus infections. Viruses. 2020;12(2):194. doi: 10.3390/v12020194.
  • 7. Wang S. Guo L. Chen L. Liu W. Cao Y. Zhang J. et al. A case report of neonatal 2019 coronavirus disease in China. Clin Infect Dis. 2020;71(15):853-7. doi: 10.1093/cid/ciaa 225.
  • 8. Qiao J. What are the risks of COVID-19 infection in pregnant women? Lancet. 2020;395(10226):760-2. doi: 10.1016/S0140-6736(20)30365-2.
  • 9. CDC COVID-19 Response Team. Severe outcomes among patients with coronavirus disease 2019 (COVID- Gynecology Obstetrics & Reproductive Medicine 2021;27(1):11-16 16 19)-United States, February 12-March 16, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(12):343-6. doi: 10. 15585/mmwr.mm6912e2.
  • 10. Royal College of Obstetricians and Gynaecologists (RCOG). COVID 19 pregnancy guidelines RCOG. United Kingdom, 2020. Available from: https://www.rcog. org.uk/globalassets/documents/guidelines/2020-10-14- coronavirus-covid-19-infection-in-pregnancy-v12.pdf
  • 11. Schwartz DA. Morotti D. Placental pathology of Covid-19 with and without fetal and neonatal infection: trophoblast necrosis and chronic histiocytic intervillositis as risk factors for transplacental transmission of SARS-CoV-2. Viruses. 2020;12(11):1308. doi: 10.3390/v12111308.
  • 12. Di Mascio D. Khalil A. Saccone G. Rizzo G. Buca D. Liberati M. et al. Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2020;2(2):100107. doi: 10.1016/j.ajogmf. 2020.100107.
  • 13. Antoun L. Taweel NE. Ahmed I. Patni S. Honest H. Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome: A prospective cohort study. Eur J Obstet Gynecol Reprod Biol. 2020;252:559- 62. doi: 10.1016/j.ejogrb.2020.07.008.
  • 14. Qiancheng X. Jian S. Lingling P. Lei H. Xiaogan J. Weihua L. et al. Coronavirus disease 2019 in pregnancy. Int J Infect Dis. 2020;95:376-83. doi: 10.1016/j.ijid.2020. 04.065.
APA Dey M, Singh S, Tiwari R, Nair V, Arora D, Tiwari S (2021). Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center. , 11 - 16. 10.21613/GORM.2021.1176
Chicago Dey Madhusudan,Singh Sanjay,Tiwari Ravindu,Nair Vinod,Arora Devendra,Tiwari Shyamji Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center. (2021): 11 - 16. 10.21613/GORM.2021.1176
MLA Dey Madhusudan,Singh Sanjay,Tiwari Ravindu,Nair Vinod,Arora Devendra,Tiwari Shyamji Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center. , 2021, ss.11 - 16. 10.21613/GORM.2021.1176
AMA Dey M,Singh S,Tiwari R,Nair V,Arora D,Tiwari S Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center. . 2021; 11 - 16. 10.21613/GORM.2021.1176
Vancouver Dey M,Singh S,Tiwari R,Nair V,Arora D,Tiwari S Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center. . 2021; 11 - 16. 10.21613/GORM.2021.1176
IEEE Dey M,Singh S,Tiwari R,Nair V,Arora D,Tiwari S "Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center." , ss.11 - 16, 2021. 10.21613/GORM.2021.1176
ISNAD Dey, Madhusudan vd. "Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center". (2021), 11-16. https://doi.org/10.21613/GORM.2021.1176
APA Dey M, Singh S, Tiwari R, Nair V, Arora D, Tiwari S (2021). Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center. GORM:Gynecology Obstetrics & Reproductive Medicine, 27(1), 11 - 16. 10.21613/GORM.2021.1176
Chicago Dey Madhusudan,Singh Sanjay,Tiwari Ravindu,Nair Vinod,Arora Devendra,Tiwari Shyamji Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center. GORM:Gynecology Obstetrics & Reproductive Medicine 27, no.1 (2021): 11 - 16. 10.21613/GORM.2021.1176
MLA Dey Madhusudan,Singh Sanjay,Tiwari Ravindu,Nair Vinod,Arora Devendra,Tiwari Shyamji Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center. GORM:Gynecology Obstetrics & Reproductive Medicine, vol.27, no.1, 2021, ss.11 - 16. 10.21613/GORM.2021.1176
AMA Dey M,Singh S,Tiwari R,Nair V,Arora D,Tiwari S Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center. GORM:Gynecology Obstetrics & Reproductive Medicine. 2021; 27(1): 11 - 16. 10.21613/GORM.2021.1176
Vancouver Dey M,Singh S,Tiwari R,Nair V,Arora D,Tiwari S Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center. GORM:Gynecology Obstetrics & Reproductive Medicine. 2021; 27(1): 11 - 16. 10.21613/GORM.2021.1176
IEEE Dey M,Singh S,Tiwari R,Nair V,Arora D,Tiwari S "Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center." GORM:Gynecology Obstetrics & Reproductive Medicine, 27, ss.11 - 16, 2021. 10.21613/GORM.2021.1176
ISNAD Dey, Madhusudan vd. "Pregnancy Outcome in First 50 SARS-CoV-2 Positive Patients at Our Center". GORM:Gynecology Obstetrics & Reproductive Medicine 27/1 (2021), 11-16. https://doi.org/10.21613/GORM.2021.1176