Coronavirus disease-2019 (COVID-19) infection was first described in the city of Wuhan in the Hubei province of China in December 2019. The causative virus was named SARS-CoV-2 due to its similarity with the severe acute respiratory syndrome (SARS) virus identified in 2002. The rapidly spreading infection was announced as a pandemic by the World Health Organization on March 11, 2020. The clinical symptoms of the disease have a wide range. The most common symptoms are fever, dry cough, myalgia or fatigue, and shortness of breath. The infectiousness of the virus is much higher than the CoVs described in previous years. It has also been reported that asymptomatic individuals can become infectious. The disease is generally diagnosed by performing reverse transcription-polymerase chain reaction test in nasopharyngeal swab samples. Direct X-ray and computed tomography are supportive of the diagnosis. Immune system functions play an important role in the prognosis of the disease. Chronic additional diseases are generally present in cases that result in death. Non-urgent examinations were postponed in forensic medicine outpatient clinics in COVID-19 infection. Forensic medicine specialists working in clinics and auxiliary personnel should be dressed following the standard personal protective equipment measures. Morgue workers should use at least FFP2 or N95 masks, face protection visors, plastic disinfectable boots, and waterproof gowns during post-mortem procedures in addition to standard measures, as they are considered to be in a very high-risk class. Firstly nasopharyngeal samples should be taken following the algorithms published by the council of forensic medicine and the result should be waited while making an autopsy decision during post-mortem examinations. In positive cases, if possible, a burial permit should be given with a death examination. Forensic cases should be performed in negative pressure salons if possible. Predominantly respiratory system pathologies such as diffuse alveolar damage, airway inflammation, pleurisy, pericarditis, lung consolidation, and pulmonary edema have been identified in the limited number of autopsy studies performed in COVID-19 infection.