Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity

Aslı AYKAÇ, (Yakın Doğu Üniversitesi, Tıp Fakültesi, Biyofizik Anabilim Dalı, Kuzey Kıbrıs Türk Cumhuriyeti)
Eda BECER, (Yakın Doğu Üniversitesi, DESAM Enstitüsü, Kuzey Kıbrıs Türk Cumhuriyeti)
Dilek ÖZBEYLİ, (Marmara Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Patoloji Teknikleri Anabilim Dalı, İstanbul, Türkiye)
Göksel ŞENER, (Marmara Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, İstanbul, Türkiye)
K. Husnu Can BASER (Yakın Doğu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Kuzey Kıbrıs Türk Cumhuriyeti)
Records of Natural Products
3 0
Yıl: 2020 Cilt: 14 Sayı: 6 Sayfa Aralığı: 395 - 404 Metin Dili: İngilizce DOI: 10.25135/rnp.186.20.04.1631 İndeks Tarihi: 21-06-2021

Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity

Öz:
Methotrexate (MTX) is an effective cytotoxic agent which is used to treat malignancies and inflammatory diseases. Origanum onites (O. onites) is found throughout the Eastern Mediterranean region and has been used in traditional medicine. The essential oils (EOs) of O. onites rich in highly bioactive phytochemicals such as carvacrol (CVR) and has antiviral, antioxidant, anticancer and proapoptotic properties. The aim of this study was to investigate the protective effects of CVR and O. onites-EO treatment in MTX-induced hepatorenal toxic rats' liver and kidney tissues. The bcl-2/bax ratio, glutathione (GSH) level, malondialdehyde (MDA) level, and myeloperoxidase (MPO) activity of liver and kidney tissues were evaluated in the MTX-induced rat model. Results showed that the administration of CVR or O. onites-EO significantly increased bcl-2/bax expression and GSH levels as well as reduced MDA level and MPO activity in the kidney and liver tissues of MTX-induced rat model. In conclusion, our results suggest that O. onites-EO and CVR have protective effect in MTX-induced hepatorenal toxic rats' liver and kidney tissues by decreasing oxidative stress and apoptosis.
Anahtar Kelime:

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APA Aykac A, Becer E, Özbeyli D, Şener G, Baser K (2020). Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity. , 395 - 404. 10.25135/rnp.186.20.04.1631
Chicago Aykac Asli,Becer Eda,Özbeyli Dilek,Şener Göksel,Baser Kemal Husnu Can Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity. (2020): 395 - 404. 10.25135/rnp.186.20.04.1631
MLA Aykac Asli,Becer Eda,Özbeyli Dilek,Şener Göksel,Baser Kemal Husnu Can Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity. , 2020, ss.395 - 404. 10.25135/rnp.186.20.04.1631
AMA Aykac A,Becer E,Özbeyli D,Şener G,Baser K Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity. . 2020; 395 - 404. 10.25135/rnp.186.20.04.1631
Vancouver Aykac A,Becer E,Özbeyli D,Şener G,Baser K Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity. . 2020; 395 - 404. 10.25135/rnp.186.20.04.1631
IEEE Aykac A,Becer E,Özbeyli D,Şener G,Baser K "Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity." , ss.395 - 404, 2020. 10.25135/rnp.186.20.04.1631
ISNAD Aykac, Asli vd. "Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity". (2020), 395-404. https://doi.org/10.25135/rnp.186.20.04.1631
APA Aykac A, Becer E, Özbeyli D, Şener G, Baser K (2020). Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity. Records of Natural Products, 14(6), 395 - 404. 10.25135/rnp.186.20.04.1631
Chicago Aykac Asli,Becer Eda,Özbeyli Dilek,Şener Göksel,Baser Kemal Husnu Can Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity. Records of Natural Products 14, no.6 (2020): 395 - 404. 10.25135/rnp.186.20.04.1631
MLA Aykac Asli,Becer Eda,Özbeyli Dilek,Şener Göksel,Baser Kemal Husnu Can Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity. Records of Natural Products, vol.14, no.6, 2020, ss.395 - 404. 10.25135/rnp.186.20.04.1631
AMA Aykac A,Becer E,Özbeyli D,Şener G,Baser K Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity. Records of Natural Products. 2020; 14(6): 395 - 404. 10.25135/rnp.186.20.04.1631
Vancouver Aykac A,Becer E,Özbeyli D,Şener G,Baser K Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity. Records of Natural Products. 2020; 14(6): 395 - 404. 10.25135/rnp.186.20.04.1631
IEEE Aykac A,Becer E,Özbeyli D,Şener G,Baser K "Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity." Records of Natural Products, 14, ss.395 - 404, 2020. 10.25135/rnp.186.20.04.1631
ISNAD Aykac, Asli vd. "Protective Effects of Origanum onites Essential Oil in theMethotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity". Records of Natural Products 14/6 (2020), 395-404. https://doi.org/10.25135/rnp.186.20.04.1631
Sayfa Oluşturulma Tarihi
17-04-2024 20:24

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