Nazlı GÖRMELİ KURT
(Acil Tıp Anabilim Dalı, Ankara Şehir Hastanesi, Ankara, Türkiye)
Şervan GÖKHAN
(Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi Acil Tıp Anabilim Dalı, Ankara Türkiye)
Özcan EREL
(Tıp Fakültesi Biyokimya Anabilim Dalı, Ankara Yıldırım Beyazıt Üniversitesi, Ankara, Türkiye)
Celal GÜNEŞ
(Batman Devlet Hastanesi, Acil Tıp Anabilim Dalı, Batman, Türkiye)
Çağdaş YILDIRIM
(Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi Acil Tıp Anabilim Dalı, Ankara, Türkiye)
Ayhan ÖZHASENEKLER
(Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi Acil Tıp Anabilim Dalı, Ankara, Türkiye)
Fatih KAHRAMAN
(Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi Acil Tıp Anabilim Dalı, Ankara, Türkiye)
Yıl: 2021Cilt: 21Sayı: 1ISSN: 1303-2283 / 2148-4570Sayfa Aralığı: 124 - 133İngilizce

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RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSED WITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENT AND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS
Objectives: To study changes in dynamic thiol/disulfide homeostasis (TDH) in patients with acute aortic dissection (AAD).Materials and Methods: In our study, the medical records of patients who applied to Ankara Atatürk Training and Research Hospital between January 2015- January 2018 and were found to have AAD on computed tomography of the thorax were retrospectively reviewed. There were two groups in the study, one AAD group,and the other healthy volunteers' group. First, thiol and disulfide levels were determined with the spectrophotometric method defined by Erel and Neşelioğlu, natural thiol (NT), total thiol (TT), and disulfide (D) levels, and their ratios were calculated (index 1: D / NT, index 2: D / TT, index 3: NT / TT). We compared these two groups in terms of Oxidative stress parameters.Results: A total of 40 patients with AAD and 38 age-matched healthy volunteers were included in this study. There was no significant difference between the two groups in terms of gender and age (p=0.923, p=0.401, respectively). The AAD group had significantly lower natural thiol and total thiol (p<0.001), but disulfide levels were similar (p=0.360). Oxidative stress parameters were not statistically significant in terms of mortality.Conclusion: We found significantly lower thiol/disulfide homeostasis in patients with AAD, particularly native thiol and total thiol. We think that oxidative stress theory may play a role in the pathophysiology of AAD and oxidative stress parameters may guide the diagnosis.
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