RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS
Yıl: 2021 Cilt: 21 Sayı: 1 Sayfa Aralığı: 124 - 133 Metin Dili: İngilizce DOI: 10.5505/amj.2021.70037 İndeks Tarihi: 21-06-2021
RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS
Öz: Objectives: To study changes in dynamic thiol/disulfide homeostasis (TDH) in patients with acute aortic dissection (AAD).Materials and Methods: In our study, the medical records of patients who applied to Ankara Atatürk Training and Research Hospital between January 2015- January 2018 and were found to have AAD on computed tomography of the thorax were retrospectively reviewed. There were two groups in the study, one AAD group,and the other healthy volunteers' group. First, thiol and disulfide levels were determined with the spectrophotometric method defined by Erel and Neşelioğlu, natural thiol (NT), total thiol (TT), and disulfide (D) levels, and their ratios were calculated (index 1: D / NT, index 2: D / TT, index 3: NT / TT). We compared these two groups in terms of Oxidative stress parameters.Results: A total of 40 patients with AAD and 38 age-matched healthy volunteers were included in this study. There was no significant difference between the two groups in terms of gender and age (p=0.923, p=0.401, respectively). The AAD group had significantly lower natural thiol and total thiol (p<0.001), but disulfide levels were similar (p=0.360). Oxidative stress parameters were not statistically significant in terms of mortality.Conclusion: We found significantly lower thiol/disulfide homeostasis in patients with AAD, particularly native thiol and total thiol. We think that oxidative stress theory may play a role in the pathophysiology of AAD and oxidative stress parameters may guide the diagnosis.
Anahtar Kelime: ACİL SERVİSTE AORT DİSEKSİYONU TANISI ALAN VE THİOL / DİSÜLFİD HOMEOSTAZİSİ ÇALIŞILAN HASTALARIN GERİYE DÖNÜK İNCELENMESİ
Öz: Amaç: Akut aort diseksiyonu (AAD) olan hastalarda dinamik tiyol / disülfid homeostazındaki (TDH)değişiklikleri incelemek. Materyal ve Metot: Çalışmamızda, Ocak 2015-Ocak 2018 tarihleri arasında Ankara Atatürk Eğitim veAraştırma Hastanesi Acil servisine başvuran ve bilgisayarlı toraks tomografisinde AAD saptanan hastalarıntıbbi kayıtları geriye dönük olarak gözden geçirildi. Çalışmada biri AAD, diğeri sağlıklı gönüllüler grubu olmaküzere iki grup mevcut idi. İlk olarak Erel ve Neşelioğlu tarafından tanımlanan spektrofotometrik yöntemletiyol ve disülfid düzeyleri belirlendi, Doğal tiyol (NT), toplam tiyol (TT) ve disülfid (D) seviyeleri ve bunlarınbirbirlerine oranları hesaplandı (indeks 1: D / NT, indeks 2: D / TT, indeks 3: NT / TT). Bu iki grubu Oksidatifstres parametreleri (Doğal Tiyol, Toplam Tiyol ve Disülfid seviyeleri) açısından karşılaştırdık. Bulgular: Toplam 40 AAD hastası ve 38 cinsiyet ve yaş uyumlu sağlıklı gönüllü bu çalışmaya dahil edildi.Cinsiyet ve yaş açısından her iki grup arasında anlamlı fark yoktu (sırasıyla p=0,923, p=0,401). AAD grubuanlamlı olarak daha düşük doğal tiyol ve toplam tiyol'e sahipti (p<0,001), ancak disülfid seviyeleri benzerdi(p=0,360). Oksitdatif stres parametreleri mortalite açısından istatistiksel olarak anlamlı bulunmadı.Sonuç: AAD'li hastalarda, özellikle native tiyol ve toplam tiyol olmak üzere, önemli ölçüde daha düşük tiyol /disülfid homeostazı saptadık. Oksidatif stres teorisinin AAD'nin patofizyolojisinde rol oynayabileceğini veoksidatf stres paremetrlerinin tanı koymada yol gösterci olabileceği kanaatindeyiz.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Görmeli Kurt N, Gökhan S, EREL O, Güneş C, Yıldırım Ç, Ozhasenekler A, Kahraman F (2021). RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS. , 124 - 133. 10.5505/amj.2021.70037 |
| Chicago | Görmeli Kurt Nazlı,Gökhan Servan,EREL Ozcan,Güneş Celal,Yıldırım Çağdaş,Ozhasenekler Ayhan,Kahraman Fatih Ahmet RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS. (2021): 124 - 133. 10.5505/amj.2021.70037 |
| MLA | Görmeli Kurt Nazlı,Gökhan Servan,EREL Ozcan,Güneş Celal,Yıldırım Çağdaş,Ozhasenekler Ayhan,Kahraman Fatih Ahmet RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS. , 2021, ss.124 - 133. 10.5505/amj.2021.70037 |
| AMA | Görmeli Kurt N,Gökhan S,EREL O,Güneş C,Yıldırım Ç,Ozhasenekler A,Kahraman F RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS. . 2021; 124 - 133. 10.5505/amj.2021.70037 |
| Vancouver | Görmeli Kurt N,Gökhan S,EREL O,Güneş C,Yıldırım Ç,Ozhasenekler A,Kahraman F RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS. . 2021; 124 - 133. 10.5505/amj.2021.70037 |
| IEEE | Görmeli Kurt N,Gökhan S,EREL O,Güneş C,Yıldırım Ç,Ozhasenekler A,Kahraman F "RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS." , ss.124 - 133, 2021. 10.5505/amj.2021.70037 |
| ISNAD | Görmeli Kurt, Nazlı vd. "RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS". (2021), 124-133. https://doi.org/10.5505/amj.2021.70037 |
| APA | Görmeli Kurt N, Gökhan S, EREL O, Güneş C, Yıldırım Ç, Ozhasenekler A, Kahraman F (2021). RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS. Ankara Medical Journal, 21(1), 124 - 133. 10.5505/amj.2021.70037 |
| Chicago | Görmeli Kurt Nazlı,Gökhan Servan,EREL Ozcan,Güneş Celal,Yıldırım Çağdaş,Ozhasenekler Ayhan,Kahraman Fatih Ahmet RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS. Ankara Medical Journal 21, no.1 (2021): 124 - 133. 10.5505/amj.2021.70037 |
| MLA | Görmeli Kurt Nazlı,Gökhan Servan,EREL Ozcan,Güneş Celal,Yıldırım Çağdaş,Ozhasenekler Ayhan,Kahraman Fatih Ahmet RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS. Ankara Medical Journal, vol.21, no.1, 2021, ss.124 - 133. 10.5505/amj.2021.70037 |
| AMA | Görmeli Kurt N,Gökhan S,EREL O,Güneş C,Yıldırım Ç,Ozhasenekler A,Kahraman F RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS. Ankara Medical Journal. 2021; 21(1): 124 - 133. 10.5505/amj.2021.70037 |
| Vancouver | Görmeli Kurt N,Gökhan S,EREL O,Güneş C,Yıldırım Ç,Ozhasenekler A,Kahraman F RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS. Ankara Medical Journal. 2021; 21(1): 124 - 133. 10.5505/amj.2021.70037 |
| IEEE | Görmeli Kurt N,Gökhan S,EREL O,Güneş C,Yıldırım Ç,Ozhasenekler A,Kahraman F "RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS." Ankara Medical Journal, 21, ss.124 - 133, 2021. 10.5505/amj.2021.70037 |
| ISNAD | Görmeli Kurt, Nazlı vd. "RETROSPECTIVE EXAMINATION OF PATIENTS DIAGNOSEDWITH AORTIC DISSECTION IN THE EMERGENCY DEPARTMENTAND UNDERGOING THIOL / DISULFIDE HOMEOSTASIS". Ankara Medical Journal 21/1 (2021), 124-133. https://doi.org/10.5505/amj.2021.70037 |
