CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS
Yıl: 2021 Cilt: 21 Sayı: 1 Sayfa Aralığı: 134 - 149 Metin Dili: İngilizce DOI: 10.5505/amj.2021.04207 İndeks Tarihi: 21-06-2021
CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS
Öz: Objectives: To compare the reverse transcription-polymerase chain reaction (RT-PCR) test results and chest computerized tomography (CT) findings in pediatric patients with a pre-diagnosis of COVID-19.Materials and Methods: The thorax CT examinations and RT-PCR test results were retrospectively evaluated in 177 children. According to the test results, the patients were divided into two groups as ‘COVID-19-positive’ and ‘COVID-19-negative’.Results: In the COVID-19-positive group, 65.71% of the patients with a family history of COVID-19 (p<0.01). In the same group, 50.00% of patients with normal CT findings were older than 16 years (p<0.01), and singlelobe involvement was more common (54.54%, p<0.01). The most observed CT finding was consolidation with ground-glass opacities (GGO) in both groups. Fibrotic bands (51.46%, p<0.01), reticular pattern (34.95%, p<0.01), atelectasis (9.71%, p<0.01), mosaic perfusion (26.21%, p<0.01), and pleural effusion (19.42%, p<0.01) were mostly seen in the COVID-19-negative group. In patients with underlying diseases, the sensitivity values were calculated as 0.441 for CT and 0.863 for the RT-PCR test.Conclusion: In patients with a family history of COVID-19, the chest CT showed focal GGO with or without consolidation as the most common finding. If CT findings diffuse and severe, the patient most likely does not have COVID-19. The RT-PCR test results are more reliable than CT in children with underlying diseases.
Anahtar Kelime: PEDİATRİK COVID-19 HASTALARINDA TORAKS BT BULGULARI VE RT-PCR TEST SONUÇLARI İLE KORELASYONU
Öz: Amaç: COVID-19 ön tanısı olan çocuk hastalarda revers transkriptaz-polimeraz zincir reaksiyon (RT-PCR) testisonuçları ile toraks bilgisayarlı tomografi (BT) bulgularını karşılaştırmak. Materyal ve Metot: Retrospektif olarak, 177 çocuk hastada toraks BT bulguları ve RT-PCR test sonuçlarıdeğerlendirildi. Test sonuçlarına göre hastalar ‘COVID-19 pozitif’ ve ‘COVID-19 negatif’ olmak üzere iki grubaayrıldı. Bulgular: COVID-19 pozitif grupta hastaların %65,71’inin ailesinde COVID-19 tanısı bulunmaktaydı (p<0.01).Aynı grupta BT bulguları normal olan hastaların %50’si 16 yaşından küçüktü (p<0,01) ve en sık tek lobtutulumu izlenmekteydi (%54,54, p<0.01). Her iki grupta en sık izlenen BT bulgusu konsolidasyon ile birliktebuzlu cam dansitesi (BCD) idi. Fibrotik bantlar (% 51,46; p<0,01), retiküler patern (% 34,95; p<0,01), atelektazi(% 9,71, p<0.01), mozaik perfüzyon (% 26,21, p<0.01), ve plevral effüzyon (% 19,42, p<0.01) COVID-19 negatifgrupta daha sık izlendi. Altta yatan hastalığı bulunanlarda BT’nin sensitivitesi 0,441, RT-PCR testin ise 0,863olarak hesaplandı. Sonuç: Ailesinde COVID-19 hastalığı olan çocuklarda en sık BT bulgusu konsolidasyonun eşlik ettiği ya daetmediği fokal BCD’dir. BT bulguları yaygın ve şiddetli ise hasta yüksek olasılıkla COVID-19 değildir. Altta yatankronik hastalığı olan çocuklarda RT-PCR testi, tanı koymada BT’den daha duyarlıdır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. World Health Organization [Internet]. The Coronavirus Disease 2019 (COVID-19) Situation Report-51. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200311-sitrep-51-covid19.pdf?sfvrsn=1ba62e57_10. (Accessed: March 11, 2020).
- 2. World Health Organization [Internet]. The Coronavirus Disease 2019 (COVID-19) Situation Report-133. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200601-covid-19-sitrep133.pdf?sfvrsn=9a56f2ac_4. (Accessed: June 1, 2020).
- 3. Sun D, Li H, Lu XX, et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center's observational study. World J Pediatr 2020;19:1-9 (doi: 10.1007/s12519-020- 00354-4).
- 4. Lu X, Zhang L, Du H, et al. SARS-CoV-2 Infection in Children. N Engl J Med 2020;382:1663-65 (doi: 10.1056/NEJMc2005073).
- 5. Su L, Ma X, Yu H, et al. The Different Clinical Characteristics of Corona Virus Disease Cases Between Children and Their Families in China - The Character of Children With COVID-19. Emerg Microbes Infect 2020;9:707-13 (doi: 10.1080/22221751.2020.1744483).
- 6. Zhang T, Cui X, Zhao X, et al. Detectable SARS-CoV-2 viral RNA in feces of three children during recovery period of COVID-19 pneumonia. J Med Virol 2020;92:909-14 (doi:10.1002/jmv.25795).
- 7. Chang TH, Wu JL, Chang LY. Clinical characteristics and diagnostic challenges of pediatric COVID-19: A systematic review and meta-analysis. J Formos Med Assoc 2020;119:982-89 (doi:10.1016/j.jfma.2020.04.007).
- 8. Hasan A, Mehmood N, Fergie J. Coronavirus Disease (COVID-19) and Pediatric Patients: A Review of Epidemiology, Symptomatology, Laboratory and Imaging Results to Guide the Development of a Management Algorithm. Cureus 2020;12:e7485 (doi: 10.7759/cureus.7485).
- 9. Pan X, Chen D, Xia Y, et al. Asymptomatic cases in a family cluster with SARS-CoV-2 infection. Lancet Infect Dis 2020;20:410-11 (doi: 10.1016/S1473-3099(20)30114-6).
- 10. Li Y, Guo F, Cao Y, Li L, Guo Y. Insight into COVID-2019 for pediatricians. Pediatr Pulmonol 2020;55:1-4 (doi: 10.1002/ppul.24734).
- 11. He JL, Luo L, Luo ZD, et al. Diagnostic performance between CT and initial real-time RT-PCR for clinically suspected 2019 coronavirus disease (COVID-19) patients outside Wuhan, China. Respir Med 2020;168:105980 (doi: 10.1016/j.rmed.2020.105980).
- 12. Foust AM, Winant AJ, Chu WC, Das KM, Phillips GS, Lee EY. Pediatric SARS, H1N1, MERS, EVALI, and Now Coronavirus Disease (COVID-19) Pneumonia: What Radiologists Need to Know. AJR Am J Roentgenol 2020;215:736-44 (doi: 10.2214/AJR.20.23267).
- 13. Turkey Ministry of Health [Internet]. COVID-19 (SARS-CoV-2 Infection) guide. https://hsgm.saglik.gov.tr/depo/birimler/goc_sagligi/covid19/rehber/COVID19_Rehberi20200414_eng_v4_002_14.05.2020.pdf. (Accessed: April 14, 2020).
- 14. Zimmermann P, Curtis N. Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children. Pediatr Infect Dis J 2020;39:355-68 (doi:10.1097/INF.0000000000002660).
- 15. de Souza TH, Nadal JA, Nogueira RJN, Pereira RM, Brandao MB. Clinical Manifestations of Children with COVID-19: a Systematic Review. Pediatr Pumonol 2020; 55: 1892-99 (doi: 10.1101/2020.04.01.20049833).
- 16. Zheng F, Liao C, Fan QH, et al. Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China. Curr Med Sci 2020;40:275-80 (doi: 10.1007/s11596-020-2172-6).
- 17. Duan YN, Zhu YQ, Tang LL, Qin J. CT features of novel coronavirus pneumonia (COVID-19) in children. Eur Radiol 2020; 30: 4427-33 (doi: 10.1007/s00330-020-06860-3).
- 18. Li W, Cui H, Li K, Fang Y, Li S. Chest computed tomography in children with COVID-19 respiratory infection. Pediatr Radiol 2020;50:796-99 (doi:10.1007/s00247-020-04656-7).
- 19. Xia W, Shao J, Peng X, Li Z, Hu D. Clinical and CT Features in Pediatric Patients With COVID-19 Infection: Different Points From Adults. Pediatr Pulmonol 2020;55:1169-74 (doi:10.1002/ppul.24718).
- 20. Chen A, Huang J, Liao Y, et al. Differences in Clinical and Imaging Presentation of Pediatric Patients with COVID-19 in Comparison with Adults. Radiology Cardiothoracic Imaging 2020;2:e200117 (doi:10.1148/ryct.2020200117).
- 21. Virkki R, Juven T, Rikalainen H, Svedstrom E, Mertsola J, Ruuskanen O. Differentiation of bacterial and viral pneumonia in children. Thorax 2002;57:438‐41 (doi:10.1136/thorax.57.5.438).
- 22. Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis 2020;20:689-96 (doi:10.1016/S1473-3099(20)30198-5).
- 23. Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients. AJR Am J Roentgenol 2020;215:87-93 (doi:10.2214/AJR.20.23034).
- 24. Fang Y, Zhang H, Xie J, et al. Sensitivity of chest CT for COVID-19: comparison to RT-PCR. Radiology 2020; 296:115-7 (doi:10.1148/radiol.2020200432).
- 25. Y Lu, H Wen, D Rong, Z Zhou, H Liu. Clinical Characteristics and Radiological Features of Children Infected With the 2019 Novel Coronavirus. Clin Radiol 2020;75:520-25 (doi: 10.1016/j.crad.2020.04.010).
- 26. Kim H, Hong H, Yoon SH. Diagnostic Performance of CT and Reverse Transcriptase-Polymerase Chain Reaction for Coronavirus Disease 2019: A Meta-Analysis. Radiology 2020;296:145-55 (doi:10.1148/radiol.2020201343).
- 27. Xie X, Zhong Z, Zhao W, Zheng C, Wang F, Liu J. Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing. Radiology 2020;296:41-45 (doi:10.1148/radiol.2020200343).
- 28. Feng K, Yun YX, Wang XF, et al. Analysis of CT features of 15 Children with 2019 novel coronavirus infection. Zhonghua Er Ke Za Zhi 2020;58:E007 (doi:10.3760/cma.j.issn.0578-1310.2020.0007).
- 29. Hosseiny M, Kooraki S, Gholamrezanezhad A, Reddy S, Myers L. Radiology Perspective of Coronavirus Disease 2019 (COVID-19): Lessons From Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome. AJR Am J Roentgenol 2020;214:1078-82 (doi:10.2214/AJR.20.22969).
- 30. Chen D, Jiang X, Hong Y, et al. Can Chest CT Features Distinguish Patients With Negative From Those With Positive Initial RT-PCR Results for Coronavirus Disease (COVID-19)? AJR Am J Roentgenol 2020;5:1-5 (doi: 10.2214/AJR.20.23012).
| APA | Bayram Ilıkan G, yılmaz ş (2021). CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS. , 134 - 149. 10.5505/amj.2021.04207 |
| Chicago | Bayram Ilıkan Gulsah,yılmaz şükriye CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS. (2021): 134 - 149. 10.5505/amj.2021.04207 |
| MLA | Bayram Ilıkan Gulsah,yılmaz şükriye CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS. , 2021, ss.134 - 149. 10.5505/amj.2021.04207 |
| AMA | Bayram Ilıkan G,yılmaz ş CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS. . 2021; 134 - 149. 10.5505/amj.2021.04207 |
| Vancouver | Bayram Ilıkan G,yılmaz ş CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS. . 2021; 134 - 149. 10.5505/amj.2021.04207 |
| IEEE | Bayram Ilıkan G,yılmaz ş "CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS." , ss.134 - 149, 2021. 10.5505/amj.2021.04207 |
| ISNAD | Bayram Ilıkan, Gulsah - yılmaz, şükriye. "CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS". (2021), 134-149. https://doi.org/10.5505/amj.2021.04207 |
| APA | Bayram Ilıkan G, yılmaz ş (2021). CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS. Ankara Medical Journal, 21(1), 134 - 149. 10.5505/amj.2021.04207 |
| Chicago | Bayram Ilıkan Gulsah,yılmaz şükriye CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS. Ankara Medical Journal 21, no.1 (2021): 134 - 149. 10.5505/amj.2021.04207 |
| MLA | Bayram Ilıkan Gulsah,yılmaz şükriye CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS. Ankara Medical Journal, vol.21, no.1, 2021, ss.134 - 149. 10.5505/amj.2021.04207 |
| AMA | Bayram Ilıkan G,yılmaz ş CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS. Ankara Medical Journal. 2021; 21(1): 134 - 149. 10.5505/amj.2021.04207 |
| Vancouver | Bayram Ilıkan G,yılmaz ş CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS. Ankara Medical Journal. 2021; 21(1): 134 - 149. 10.5505/amj.2021.04207 |
| IEEE | Bayram Ilıkan G,yılmaz ş "CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS." Ankara Medical Journal, 21, ss.134 - 149, 2021. 10.5505/amj.2021.04207 |
| ISNAD | Bayram Ilıkan, Gulsah - yılmaz, şükriye. "CHEST CT FINDINGS AND THEIR CORRELATION WITHRT-PCR TESTING IN PEDIATRIC COVID-19 PATIENTS". Ankara Medical Journal 21/1 (2021), 134-149. https://doi.org/10.5505/amj.2021.04207 |
