The sharp rise in gender diversity has led to an increased likelihood of general health workers encountering this group of patients. Awareness and approach of physicians working in primary health care about the sexualorientation and gender identity of the patients are important to provide a qualified and comprehensive healthservice. In this context, considering the health needs of transgender individuals and the problems theyexperience in accessing health services, the management of these people in primary care requires specialattention. Primary, secondary and tertiary prevention services can be provided for trans men and trans womenin primary health care. Ideally, a multidisciplinary approach including primary care physicians, psychiatrists,endocrinologists, and surgeons should be adopted for healthcare services for transgender people. The aim ofthis review is to determine the principles of the management of transgender people and the health servicesthat should be provided to them using current guidelines and to assist physicians in providing primaryhealthcare services to these patients.