Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19
Yıl: 2021 Cilt: 9 Sayı: 1 Sayfa Aralığı: 4 - 8 Metin Dili: İngilizce DOI: 10.14235/bas.galenos.2020.4884 İndeks Tarihi: 21-06-2021
Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19
Öz: Objective: The purpose of this study is to examine the levels ofC-reactive protein (CRP) and D-dimer by age and gender in thepandemic caused by the new coronavirus.Methods: Coronavirus disease-19 (COVID-19) diagnoses weremade according to the results of real-time polymerase chainreaction and lung computed tomography (n=70). In the study,CRP and coagulation were examined as indicators of inflammation,and D-dimer was examined as an indicator of fibrinolytic systemactivity. Patients’ age, gender, and CRP and D-dimer values wereanalyzed with Spearman’s rho correlation, whereas the gender factorwas analyzed with the Mann-Whitney U test.Results: Although D-dimer levels were high in women, there wasno statistical significance. A correlation was identified between CRPand gender, and the levels in male patients were higher (p=0.049).A positive correlation was found between the patients’ age and CRPand D-dimer findings.Conclusion: There are two main findings in this study. First, ageand gender are essential parameters in disease findings due to theCOVID-19 pandemic. Their importance overlaps with the findingthat inflammation is severe in elderly males and that the mortality ishigher than in younger individuals. Second, the CRP and D-dimertest results can be used as practical and reliable biomarkers forCOVID-19. We propose that if these two tests, which are alreadyused routinely, are interpreted with consideration of age and gender,they can be used more efficiently in early diagnosis and isolation.
Anahtar Kelime: COVİD-19 Hastalarında C-reaktif Protein ve D-dimer Bulgularının İncelenmesi
Öz: Amaç: Bu çalışmanın amacı, yeni koronavirüsün neden olduğu pandemide ilk tanı konulduğu anda C-reaktif protein (CRP) ve D-dimer düzeylerinin yaş ve cinsiyete göre incelenmesidir. Yöntemler: Gerçek zamanlı polimeraz zincir reaksiyonu ve akciğer bilgisayarlı tomografi (n=70) sonuçlarına göre COVİD-19 tanıları konuldu. CRP inflamasyonun göstergeleri olarak, D-dimer ise fibrinolitik sistem aktivitesinin bir göstergesi olarak incelendi. Hastaların yaşı, cinsiyeti, CRP ve D-dimer değerleri Spearman'ın rho korelasyonu ile analiz edilirken cinsiyet faktörü Mann-Whitney U testi ile analiz edildi. Bulgular: Kadınlarda D-dimer düzeyleri yüksek bulundu, ancak istatistiksel olarak anlamlılık tespit edilmedi. Erkek hastalarda ise CRP düzeyleri anlamlı olarak yüksek bulundu (p=0,049). Hasta yaşı ile CRP ve D-dimer arasında pozitif korelasyon bulundu. Sonuç: Çalışmada iki ana sonuç ortaya çıktı. Birincisi, yaş ve cinsiyetin COVİD-19 salgını nedeniyle gerçekleşen hastalıkta önemli bir parametre olduğudur. Bu bulgu, yaşlı erkeklerde inflamasyonun şiddetli olduğu ve gençlere göre ölüm oranının daha yüksek olması bulgusuyla örtüşmektedir. İkinci sonuç ise, CRP ve D-dimer testlerinin COVİD-19 için pratik ve güvenilir bir belirteç olabileceğidir. Zaten rutin olarak kullanılan bu iki testin yaş ve cinsiyet dikkate alınarak yorumlanması halinde erken teşhis ve izolasyonda daha verimli kullanılabileceğini öneriyoruz.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | yazar h, Kayacan Y, Özdin M (2021). Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19. , 4 - 8. 10.14235/bas.galenos.2020.4884 |
| Chicago | yazar hayrullah,Kayacan Yildirim,Özdin Mehmet Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19. (2021): 4 - 8. 10.14235/bas.galenos.2020.4884 |
| MLA | yazar hayrullah,Kayacan Yildirim,Özdin Mehmet Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19. , 2021, ss.4 - 8. 10.14235/bas.galenos.2020.4884 |
| AMA | yazar h,Kayacan Y,Özdin M Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19. . 2021; 4 - 8. 10.14235/bas.galenos.2020.4884 |
| Vancouver | yazar h,Kayacan Y,Özdin M Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19. . 2021; 4 - 8. 10.14235/bas.galenos.2020.4884 |
| IEEE | yazar h,Kayacan Y,Özdin M "Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19." , ss.4 - 8, 2021. 10.14235/bas.galenos.2020.4884 |
| ISNAD | yazar, hayrullah vd. "Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19". (2021), 4-8. https://doi.org/10.14235/bas.galenos.2020.4884 |
| APA | yazar h, Kayacan Y, Özdin M (2021). Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19. Bezmiâlem Science, 9(1), 4 - 8. 10.14235/bas.galenos.2020.4884 |
| Chicago | yazar hayrullah,Kayacan Yildirim,Özdin Mehmet Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19. Bezmiâlem Science 9, no.1 (2021): 4 - 8. 10.14235/bas.galenos.2020.4884 |
| MLA | yazar hayrullah,Kayacan Yildirim,Özdin Mehmet Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19. Bezmiâlem Science, vol.9, no.1, 2021, ss.4 - 8. 10.14235/bas.galenos.2020.4884 |
| AMA | yazar h,Kayacan Y,Özdin M Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19. Bezmiâlem Science. 2021; 9(1): 4 - 8. 10.14235/bas.galenos.2020.4884 |
| Vancouver | yazar h,Kayacan Y,Özdin M Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19. Bezmiâlem Science. 2021; 9(1): 4 - 8. 10.14235/bas.galenos.2020.4884 |
| IEEE | yazar h,Kayacan Y,Özdin M "Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19." Bezmiâlem Science, 9, ss.4 - 8, 2021. 10.14235/bas.galenos.2020.4884 |
| ISNAD | yazar, hayrullah vd. "Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19". Bezmiâlem Science 9/1 (2021), 4-8. https://doi.org/10.14235/bas.galenos.2020.4884 |
