Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine
Yıl: 2020 Cilt: 14 Sayı: 1 Sayfa Aralığı: 2 - 6 Metin Dili: İngilizce DOI: 10.12956/tchd.578335 İndeks Tarihi: 25-06-2021
Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine
Öz: Objective: Methemoglobinemia is a clinical entity characterized by substitution of ferrous iron (Fe+2) in the hemoglobinstructure by ferric iron (Fe+3) that lacks oxygen carrying capacity. Acquired methemoglobinemia may occur due tooxidant substances and drugs, of which local anesthetics constitute an important group. In this study the incidence ofprilocaine-induced methemoglobinemia was studied.Material and Methods: This study was performed on children who presented to the urology department forcircumcision in 2013. Methemoglobin levels were measured prior to and after prilocaine injection.Results: The study enrolled 74 children aged 6 months to 12 years. Five patients with a known hematological disorderor those with chronic disorders were excluded. Of the cases, 20.2 % were found to have methemoglobinemia butnone had symptoms. Mean preoperative and postoperative incidences of methemoglobin were 0.71% and 1.80%,respectively. Methemoglobin level was reduced as age of the patient increased.Conclusion: The risk of methemoglobinemia should be considered with local anesthetic agents widely used in clinicalpractice, particularly in small age groups.
Anahtar Kelime: Prilokain Kullanılarak Sünnet Yapılan Çocuklarda Methemoglobinemi Sıklığının Araştırılması
Öz: Amaç: Methemoglobinemi, hemoglobindeki ferröz demirin (Fe+2) yerini oksijen taşıma kapasitesi olmayan ferrik demirin (Fe+3) alması ile karakterize bir klinik durumdur. Edinsel methemoglobinemi, oksidan maddeler ve ilaçlara bağlı olarak ortaya çıkabilirken, lokal anestezikler ilaçlar arasında önemli bir grubu oluşturur. Bu çalışmada prilokaine bağlı methemoglobinemi sıklığı araştırılmıştır. Gereç ve Yöntemler: Çalışma 2013 yılında üroloji polikliniğine sünnet amacıyla başvuran çocuklar arasında yapıldı. Prilokain öncesi ve sonrası methemoglobin düzeyleri araştırıldı. Bulgular: Çalışmaya yaşları 6 ay ile 12 yaş arasında değişen 74 çocuk dahil edildi. Bilinen hematolojik ve kronik hastalığı olanlar çıkarılmıştır. Olguların %20.2’sinde methemoglobinemi saptanırken semptomatik olan olgu saptanmadı. Methemoglobin ortalaması %0.71, postoperatif %1.80 olarak saptandı. Yaşın artışına parelel olarak methemoglobin düzeyinin azaldığı gözlendi. Sonuç: Günlük pratikte sıklıkla kullanılan lokal anesteziklerin kullanımı ile özellikle küçük yaş grubunda methemoglobinemi riski göz önünde bulundurulmalıdır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Topal Y, Deliktas H, TOPAL H, Çetinkaya M, Kocabas C (2020). Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine. , 2 - 6. 10.12956/tchd.578335 |
| Chicago | Topal Yasar,Deliktas Hasan,TOPAL HATICE,Çetinkaya Mehmet,Kocabas Can Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine. (2020): 2 - 6. 10.12956/tchd.578335 |
| MLA | Topal Yasar,Deliktas Hasan,TOPAL HATICE,Çetinkaya Mehmet,Kocabas Can Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine. , 2020, ss.2 - 6. 10.12956/tchd.578335 |
| AMA | Topal Y,Deliktas H,TOPAL H,Çetinkaya M,Kocabas C Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine. . 2020; 2 - 6. 10.12956/tchd.578335 |
| Vancouver | Topal Y,Deliktas H,TOPAL H,Çetinkaya M,Kocabas C Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine. . 2020; 2 - 6. 10.12956/tchd.578335 |
| IEEE | Topal Y,Deliktas H,TOPAL H,Çetinkaya M,Kocabas C "Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine." , ss.2 - 6, 2020. 10.12956/tchd.578335 |
| ISNAD | Topal, Yasar vd. "Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine". (2020), 2-6. https://doi.org/10.12956/tchd.578335 |
| APA | Topal Y, Deliktas H, TOPAL H, Çetinkaya M, Kocabas C (2020). Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine. Türkiye Çocuk Hastalıkları Dergisi, 14(1), 2 - 6. 10.12956/tchd.578335 |
| Chicago | Topal Yasar,Deliktas Hasan,TOPAL HATICE,Çetinkaya Mehmet,Kocabas Can Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine. Türkiye Çocuk Hastalıkları Dergisi 14, no.1 (2020): 2 - 6. 10.12956/tchd.578335 |
| MLA | Topal Yasar,Deliktas Hasan,TOPAL HATICE,Çetinkaya Mehmet,Kocabas Can Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine. Türkiye Çocuk Hastalıkları Dergisi, vol.14, no.1, 2020, ss.2 - 6. 10.12956/tchd.578335 |
| AMA | Topal Y,Deliktas H,TOPAL H,Çetinkaya M,Kocabas C Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine. Türkiye Çocuk Hastalıkları Dergisi. 2020; 14(1): 2 - 6. 10.12956/tchd.578335 |
| Vancouver | Topal Y,Deliktas H,TOPAL H,Çetinkaya M,Kocabas C Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine. Türkiye Çocuk Hastalıkları Dergisi. 2020; 14(1): 2 - 6. 10.12956/tchd.578335 |
| IEEE | Topal Y,Deliktas H,TOPAL H,Çetinkaya M,Kocabas C "Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine." Türkiye Çocuk Hastalıkları Dergisi, 14, ss.2 - 6, 2020. 10.12956/tchd.578335 |
| ISNAD | Topal, Yasar vd. "Investigation of Methemoglobinemia İncidence Among Children Undergoing Circumcision Using Prilocaine". Türkiye Çocuk Hastalıkları Dergisi 14/1 (2020), 2-6. https://doi.org/10.12956/tchd.578335 |
