Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?

Tatar, Abdulgani; keles, muzaffer; Yuce Kahraman, Cigdem; Ocak, Zeynep; Tatar, Arzu

doi:10.5152/eurasianjmed.2021.20006

Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?

Çiğdem YÜCE KAHRAMAN, (Atatürk Üniversitesi Tıp Fakültesi Tıbbi Genetik Anabilim Dalı, Erzurum, Türkiye)

Arzu TATAR, (Atatürk Üniversitesi Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, Erzurum, Türkiye)

Muzaffer KELEŞ, (Atatürk Üniversitesi Tıp Fakültesi Tıbbi Patoloji Anabilim Dalı, Erzurum, Türkiye)

Zeynep İpek OCAK, (Tıbbi Biyoloji ve Genetik Anabilim Dalı, Yeni Yüzil Üniversitesi, İstanbul, Türkiye)

Abdulgani TATAR (Atatürk Üniversitesi Tıp Fakültesi Tıbbi Genetik Anabilim Dalı, Erzurum, Türkiye)

Eurasian Journal of Medicine

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Yıl: 2021 Cilt: 53 Sayı: 1 Sayfa Aralığı: 19 - 21 Metin Dili: İngilizce DOI: 10.5152/eurasianjmed.2021.20006 İndeks Tarihi: 28-06-2021

Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?

Öz:

Objective: Nasal polyposis (NP) is an inflammatory chronic disease in which polyps are located in the nose orparanasal sinuses. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) genes haveroles in vascular biology, inflammation, tissue morphogenesis, and pathophysiological remodeling. Therefore,some members of the ADAMTS gene family may contribute to pathogenesis of NPs. This study aimed todetect the potential relation between NP and the expression levels of ADAMTS 5, 8, and 9 genes.Materials and Methods: This study consisted of nasal polyp tissues from 34 patients in whom nasal polypshad been diagnosed clinically, and healthy nasal mucosal tissues from 14 controls. RNA was isolated from thenasal polyps and normal nasal mucosal tissue in each subject. The expression levels of ADAMTS 5, 8, and 9genes in the patients and controls were detected by quantitative real-time reverse transcriptase polymerasechain reaction (qRT-PCR) method.Results: The expression levels of ADAMTS 5 and 9 genes were significantly decreased in NP tissues. Incontrast, the expression levels of ADAMTS 8 genes were also decreased in NP tissues, but they were notsignificantly different from those in the normal nasal tissues.Conclusion: An association was detected between the expression levels of ADAMTS genes and NP. ADAMTS 5 and 9 genes may have an effect on the formation of NP

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Yuce Kahraman C, Tatar A, keles m, Ocak Z, Tatar A (2021). Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?. , 19 - 21. 10.5152/eurasianjmed.2021.20006
Chicago	Yuce Kahraman Cigdem,Tatar Arzu,keles muzaffer,Ocak Zeynep,Tatar Abdulgani Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?. (2021): 19 - 21. 10.5152/eurasianjmed.2021.20006
MLA	Yuce Kahraman Cigdem,Tatar Arzu,keles muzaffer,Ocak Zeynep,Tatar Abdulgani Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?. , 2021, ss.19 - 21. 10.5152/eurasianjmed.2021.20006
AMA	Yuce Kahraman C,Tatar A,keles m,Ocak Z,Tatar A Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?. . 2021; 19 - 21. 10.5152/eurasianjmed.2021.20006
Vancouver	Yuce Kahraman C,Tatar A,keles m,Ocak Z,Tatar A Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?. . 2021; 19 - 21. 10.5152/eurasianjmed.2021.20006
IEEE	Yuce Kahraman C,Tatar A,keles m,Ocak Z,Tatar A "Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?." , ss.19 - 21, 2021. 10.5152/eurasianjmed.2021.20006
ISNAD	Yuce Kahraman, Cigdem vd. "Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?". (2021), 19-21. https://doi.org/10.5152/eurasianjmed.2021.20006

APA	Yuce Kahraman C, Tatar A, keles m, Ocak Z, Tatar A (2021). Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?. Eurasian Journal of Medicine, 53(1), 19 - 21. 10.5152/eurasianjmed.2021.20006
Chicago	Yuce Kahraman Cigdem,Tatar Arzu,keles muzaffer,Ocak Zeynep,Tatar Abdulgani Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?. Eurasian Journal of Medicine 53, no.1 (2021): 19 - 21. 10.5152/eurasianjmed.2021.20006
MLA	Yuce Kahraman Cigdem,Tatar Arzu,keles muzaffer,Ocak Zeynep,Tatar Abdulgani Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?. Eurasian Journal of Medicine, vol.53, no.1, 2021, ss.19 - 21. 10.5152/eurasianjmed.2021.20006
AMA	Yuce Kahraman C,Tatar A,keles m,Ocak Z,Tatar A Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?. Eurasian Journal of Medicine. 2021; 53(1): 19 - 21. 10.5152/eurasianjmed.2021.20006
Vancouver	Yuce Kahraman C,Tatar A,keles m,Ocak Z,Tatar A Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?. Eurasian Journal of Medicine. 2021; 53(1): 19 - 21. 10.5152/eurasianjmed.2021.20006
IEEE	Yuce Kahraman C,Tatar A,keles m,Ocak Z,Tatar A "Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?." Eurasian Journal of Medicine, 53, ss.19 - 21, 2021. 10.5152/eurasianjmed.2021.20006
ISNAD	Yuce Kahraman, Cigdem vd. "Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?". Eurasian Journal of Medicine 53/1 (2021), 19-21. https://doi.org/10.5152/eurasianjmed.2021.20006