Investigation of oxidative stress in experimental periodontitis treated with myricetin

keleş, zeynep pınar; BALLI, Umut; Gulsoy, Zehra; Guven, Berrak

doi:10.5455/annalsmedres.2020.02.124

Investigation of oxidative stress in experimental periodontitis treated with myricetin

Zeynep Pınar KELEŞ YÜCEL, (Giresun Üniversitesi Diş Hekimliği Fakültesi Periodontoloji Anabilim Dalı, Giresun, Türkiye)

Berrak GÜVEN, (Zonguldak Bülent Ecevit Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, Zonguldak, Türkiye)

Umut BALLI (Zonguldak Bülent Ecevit Üniversitesi Diş Hekimliği Fakültesi Periodontoloji Anabilim Dalı, Zonguldak, Türkiye)

Annals of Medical Research

1 0

Yıl: 2020 Cilt: 27 Sayı: 12 Sayfa Aralığı: 3272 - 3277 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2020.02.124 İndeks Tarihi: 28-06-2021

Investigation of oxidative stress in experimental periodontitis treated with myricetin

Öz:

Aim: The aim of this study was to investigate the effects of systemically applied myricetin on oxidative stress and antioxidant status in experimental periodontitis of rats. Materials and Methods: 24 Wistar rats were used and randomly divided into three groups. Experimental periodontitis was induced by placing a silk ligature around first molars teeth of the rats for 15 days. Following removal of the ligatures, Group 1: saline; Group 2: myricetin and Group 3: doxycycline were administered systemically. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD) enzyme and malondialdehyde (MDA) levels in serum; and SOD and MDA levels in gingival tissue were determined by biochemical analysis. Results: Serum TAS increased and serum TOS and OSI values decreased in myricetin and doxycycline treated groups compared to saline group (P<0.016). There were no statistically significant differences in serum SOD levels between groups (P>0.016). Gingival tissue SOD activity was increased in the group treated with doxycycline compared with the group treated with saline (P<0.016). MDA levels in both serum and gingival tissue samples were decreased in myricetin and doxycycline treated groups compared to saline group (P<0.016). Conclusion: The systemic administration of myricetin may be useful to diminish oxidative damage in periodontitis.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Gulsoy Z, keleş z, Guven B, BALLI U (2020). Investigation of oxidative stress in experimental periodontitis treated with myricetin. , 3272 - 3277. 10.5455/annalsmedres.2020.02.124
Chicago	Gulsoy Zehra,keleş zeynep pınar,Guven Berrak,BALLI Umut Investigation of oxidative stress in experimental periodontitis treated with myricetin. (2020): 3272 - 3277. 10.5455/annalsmedres.2020.02.124
MLA	Gulsoy Zehra,keleş zeynep pınar,Guven Berrak,BALLI Umut Investigation of oxidative stress in experimental periodontitis treated with myricetin. , 2020, ss.3272 - 3277. 10.5455/annalsmedres.2020.02.124
AMA	Gulsoy Z,keleş z,Guven B,BALLI U Investigation of oxidative stress in experimental periodontitis treated with myricetin. . 2020; 3272 - 3277. 10.5455/annalsmedres.2020.02.124
Vancouver	Gulsoy Z,keleş z,Guven B,BALLI U Investigation of oxidative stress in experimental periodontitis treated with myricetin. . 2020; 3272 - 3277. 10.5455/annalsmedres.2020.02.124
IEEE	Gulsoy Z,keleş z,Guven B,BALLI U "Investigation of oxidative stress in experimental periodontitis treated with myricetin." , ss.3272 - 3277, 2020. 10.5455/annalsmedres.2020.02.124
ISNAD	Gulsoy, Zehra vd. "Investigation of oxidative stress in experimental periodontitis treated with myricetin". (2020), 3272-3277. https://doi.org/10.5455/annalsmedres.2020.02.124

APA	Gulsoy Z, keleş z, Guven B, BALLI U (2020). Investigation of oxidative stress in experimental periodontitis treated with myricetin. Annals of Medical Research, 27(12), 3272 - 3277. 10.5455/annalsmedres.2020.02.124
Chicago	Gulsoy Zehra,keleş zeynep pınar,Guven Berrak,BALLI Umut Investigation of oxidative stress in experimental periodontitis treated with myricetin. Annals of Medical Research 27, no.12 (2020): 3272 - 3277. 10.5455/annalsmedres.2020.02.124
MLA	Gulsoy Zehra,keleş zeynep pınar,Guven Berrak,BALLI Umut Investigation of oxidative stress in experimental periodontitis treated with myricetin. Annals of Medical Research, vol.27, no.12, 2020, ss.3272 - 3277. 10.5455/annalsmedres.2020.02.124
AMA	Gulsoy Z,keleş z,Guven B,BALLI U Investigation of oxidative stress in experimental periodontitis treated with myricetin. Annals of Medical Research. 2020; 27(12): 3272 - 3277. 10.5455/annalsmedres.2020.02.124
Vancouver	Gulsoy Z,keleş z,Guven B,BALLI U Investigation of oxidative stress in experimental periodontitis treated with myricetin. Annals of Medical Research. 2020; 27(12): 3272 - 3277. 10.5455/annalsmedres.2020.02.124
IEEE	Gulsoy Z,keleş z,Guven B,BALLI U "Investigation of oxidative stress in experimental periodontitis treated with myricetin." Annals of Medical Research, 27, ss.3272 - 3277, 2020. 10.5455/annalsmedres.2020.02.124
ISNAD	Gulsoy, Zehra vd. "Investigation of oxidative stress in experimental periodontitis treated with myricetin". Annals of Medical Research 27/12 (2020), 3272-3277. https://doi.org/10.5455/annalsmedres.2020.02.124