Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study
Yıl: 2021 Cilt: 46 Sayı: 1 Sayfa Aralığı: 1 - 10 Metin Dili: İngilizce DOI: 10.17826/cumj.783433 İndeks Tarihi: 29-06-2021
Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study
Öz: Purpose: Serum cystatin C level is a specific marker toestimate the glomerular filtration rate (GFR). Due to thisspecificity, we assume that GFR estimations based oncystatin C have higher diagnostic performances than GFRestimations using other biomarkers. In this study, weaimed to compared the diagnostic performances of CKDEPI cystatin C equation, CKD-EPI creatinine equationand 24-hour creatinine clearance to estimate GFR.Materials and Methods: A total of 130 participants whoconsisting of 101 acute and chronic renal disease patientsand 29 healthy volunteers, who applied to the NephrologyClinic, have been included in our study. Their urinecreatinine levels and serum creatinine levels were measuredby the colorimetric-Jaffe method, and cystatin C was bythe nephelometric method.Results: There was a statistically significant relationshipbetween CKD-EPI cystatin C, between CKD-EPIcreatinine and standard creatinine clearance. The AreaUnder the Receiver Operating Characteristics curve(AUROC) was found to be 1, 0.995, and 0.954respectively.Conclusion: According to the results, we think that serumcystatin C levels will present earlier findings in GFRdecrease and may be a more effective marker than serumcreatinine and standard creatinine clearance in the earlyperiod.
Anahtar Kelime: GFR tahmininde CKD-EPI sistatin-C, CKD-EPI kreatinin ve 24 saatlik kreatinin klirensinin tanısal doğruluğunun karşılaştırılması: bir ön çalışma
Öz: Amaç: Serum sistatin C düzeyi, glomerüler filtrasyon hızını (GFH) tahmin etmek için spesifik bir belirteçtir. Bu özgüllük nedeniyle, sistatin C'ye dayalı GFH tahminlerinin, diğer biyobelirteçleri kullanan GFH tahminlerinden daha yüksek tanısal performanslara sahip olduğunu varsayıyoruz. Bu çalışmada, GFH'yi tahmin etmek için CKD-EPI sistatin C denklemi, CKD-EPI kreatinin denklemi ve 24 saatlik kreatinin klirensinin tanısal performanslarını karşılaştırmayı amaçladık. Gereç ve Yöntem: Çalışmamıza Nefroloji Kliniğine başvuran akut ve kronik böbrek hastalarından oluşan 101 hasta ve 29 sağlıklı gönüllüden oluşan toplam 130 katılımcıdâhil edildi. İdrar kreatinin düzeyleri ve serum kreatinin düzeyleri kolorimetrik-Jaffe yöntemi ile ölçülürken, sistatin C nefelometrik yöntemle ölçüldü. Bulgular: CKD-EPI sistatin C, CKD-EPI kreatinin ve standart kreatinin klirensi arasında istatistiksel olarak anlamlı bir ilişki vardı. Alıcı Çalışma Karakteristikleri eğrisinin (AUROC) Altındaki Alan sırasıyla 1, 0.995 ve 0.954 olarak bulundu. Sonuç: Elde edilen sonuçlara göre, serum sistatin C düzeylerinin GFH azalmasında daha erken bulgular sunacağı ve erken dönemde serum kreatinin ve standart kreatinin klirensinden daha etkili bir belirteç olabileceği kanısındayız.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | UÇUCU S, AYAN D, SERİN E (2021). Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study. , 1 - 10. 10.17826/cumj.783433 |
| Chicago | UÇUCU SÜHEYL,AYAN Durmuş,SERİN Erdinç Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study. (2021): 1 - 10. 10.17826/cumj.783433 |
| MLA | UÇUCU SÜHEYL,AYAN Durmuş,SERİN Erdinç Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study. , 2021, ss.1 - 10. 10.17826/cumj.783433 |
| AMA | UÇUCU S,AYAN D,SERİN E Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study. . 2021; 1 - 10. 10.17826/cumj.783433 |
| Vancouver | UÇUCU S,AYAN D,SERİN E Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study. . 2021; 1 - 10. 10.17826/cumj.783433 |
| IEEE | UÇUCU S,AYAN D,SERİN E "Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study." , ss.1 - 10, 2021. 10.17826/cumj.783433 |
| ISNAD | UÇUCU, SÜHEYL vd. "Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study". (2021), 1-10. https://doi.org/10.17826/cumj.783433 |
| APA | UÇUCU S, AYAN D, SERİN E (2021). Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study. Cukurova Medical Journal, 46(1), 1 - 10. 10.17826/cumj.783433 |
| Chicago | UÇUCU SÜHEYL,AYAN Durmuş,SERİN Erdinç Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study. Cukurova Medical Journal 46, no.1 (2021): 1 - 10. 10.17826/cumj.783433 |
| MLA | UÇUCU SÜHEYL,AYAN Durmuş,SERİN Erdinç Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study. Cukurova Medical Journal, vol.46, no.1, 2021, ss.1 - 10. 10.17826/cumj.783433 |
| AMA | UÇUCU S,AYAN D,SERİN E Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study. Cukurova Medical Journal. 2021; 46(1): 1 - 10. 10.17826/cumj.783433 |
| Vancouver | UÇUCU S,AYAN D,SERİN E Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study. Cukurova Medical Journal. 2021; 46(1): 1 - 10. 10.17826/cumj.783433 |
| IEEE | UÇUCU S,AYAN D,SERİN E "Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study." Cukurova Medical Journal, 46, ss.1 - 10, 2021. 10.17826/cumj.783433 |
| ISNAD | UÇUCU, SÜHEYL vd. "Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKDEPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study". Cukurova Medical Journal 46/1 (2021), 1-10. https://doi.org/10.17826/cumj.783433 |
