Yıl: 2021 Cilt: 46 Sayı: 1 Sayfa Aralığı: 108 - 115 Metin Dili: Türkçe DOI: 10.17826/cumj.786762 İndeks Tarihi: 30-06-2021

Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri

Öz:
Amaç: Bu çalışmada; obez hastalarda metabolik sendromgörülme sıklığının belirlenmesi ve metabolik sendromluobez hastalarda serum ürik asit düzeylerinindeğerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: Retrospektif çalışmaya Kasım 2018-Şubat 2020 tarihleri arasında Sağlık Bilimleri ÜniversitesiAntalya Eğitim ve Araştırma Hastanesi ObeziteMerkezinde takipli 270 obez hasta dahil edildi. Metaboliksendrom olan ve olmayan şeklinde iki gruba ayrılan hastalarserum ürik asit düzeyleri ve diğer çalışma parametreleriaçısından karşılaştırıldı.Bulgular: Hastaların %92,6’sı kadın, %7,4'ü erkekti.Ortalama yaş 51,8±9,6 (21–73) yıl idi. 141 hastada(%52,22) metabolik sendrom vardı. Metabolik sendromolan hastalarda kilo, vücut kitle indeksi, bel/kalça oranıölçümleri anlamlı yüksek bulundu. Metabolik sendromparametrelerinin yanı sıra glikozillenmiş hemoglobin, açlıkinsülini, insülin direnci ve ürik asit düzeyleri de metaboliksendrom olan grupta anlamlı yüksekti. Metabolik sendromolan hastalarda ürik asit ile bel çevresi, açlık insülini veinsülin direnci arasında istatistiksel olarak anlamlı pozitifbir korelasyon saptandı. Çok değişkenli lojistik regresyonanalizi; ürik asitin diğer parametrelerden bağımsız olarakmetabolik sendrom riskini arttırdığını gösterdi.Sonuç: Obez hastalarda metabolik sendrom görülmesıklığı artmaktadır ve metabolik sendromun eşlik ettiğiobez hastalarda serum ürik asit düzeyleri yükselmektedir.Ayrıca bu hastalarda serum ürik asit düzeyleri ile bel çevresive insülin direnci arasında pozitif korelasyongörülmektedir. Bu bağlamda, özellikle abdominal obeziteve insülin direnci tespit edilen metabolik sendromlu obezhastalar kardiyovasküler hastalık risk belirteci olarakdeğerlendirilen hiperürisemi açısından taranmalıdır.
Anahtar Kelime:

Serum uric acid levels in obese patients with metabolic syndrome

Öz:
Purpose: The aim of this study was to determine the frequency of metabolic syndrome in obese patients and to evaluate serum uric acid levels in obese patients with metabolic syndrome. Materials and Methods: The retrospective study included 270 obese patients with follow-up at the Obesity Center of Health Sciences University Antalya Training and Research Hospital between November 2018 and February 2020. Patients who were divided into two groups with and without metabolic syndrome were compared in terms of serum uric acid levels. Results: Of the patients 92,6% were female and 7,4% were male. The average age was 51,8±9,6 years. 141 patients (52,22%) had metabolic syndrome. Weight, body mass indexe, waist/hip ratio were significantly higher in patients with metabolic syndrome. In addition to metabolic syndrome parameters, glycosylated hemoglobin, fasting insulin, insulin resistance and uric acid levels were also significantly higher in the group with metabolic syndrome. A statistically significant positive correlation was found between uric acid and waist circumference, fasting insulin and insulin resistance in patients with metabolic syndrome. Multivariate logistic regression analysis showed that uric acid increased the risk of metabolic syndrome regardless of other parameters. Conclusion: The frequency of metabolic syndrome increases in obese patients, and serum uric acid levels increase in obese patients accompanied by metabolic syndrome. In addition, there is a positive correlation between serum uric acid levels and waist circumference and insulin resistance in these patients. Especially obese patients with metabolic syndrome accompanying with abdominal obesity and insülin resistance should be screened for hyperuricemia, which is considered as a cardiovascular disease risk marker.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA NUR EKE R (2021). Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri. , 108 - 115. 10.17826/cumj.786762
Chicago NUR EKE REMZİYE Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri. (2021): 108 - 115. 10.17826/cumj.786762
MLA NUR EKE REMZİYE Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri. , 2021, ss.108 - 115. 10.17826/cumj.786762
AMA NUR EKE R Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri. . 2021; 108 - 115. 10.17826/cumj.786762
Vancouver NUR EKE R Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri. . 2021; 108 - 115. 10.17826/cumj.786762
IEEE NUR EKE R "Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri." , ss.108 - 115, 2021. 10.17826/cumj.786762
ISNAD NUR EKE, REMZİYE. "Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri". (2021), 108-115. https://doi.org/10.17826/cumj.786762
APA NUR EKE R (2021). Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri. Cukurova Medical Journal, 46(1), 108 - 115. 10.17826/cumj.786762
Chicago NUR EKE REMZİYE Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri. Cukurova Medical Journal 46, no.1 (2021): 108 - 115. 10.17826/cumj.786762
MLA NUR EKE REMZİYE Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri. Cukurova Medical Journal, vol.46, no.1, 2021, ss.108 - 115. 10.17826/cumj.786762
AMA NUR EKE R Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri. Cukurova Medical Journal. 2021; 46(1): 108 - 115. 10.17826/cumj.786762
Vancouver NUR EKE R Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri. Cukurova Medical Journal. 2021; 46(1): 108 - 115. 10.17826/cumj.786762
IEEE NUR EKE R "Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri." Cukurova Medical Journal, 46, ss.108 - 115, 2021. 10.17826/cumj.786762
ISNAD NUR EKE, REMZİYE. "Metabolik sendromlu obez hastalarda serum ürik asit düzeyleri". Cukurova Medical Journal 46/1 (2021), 108-115. https://doi.org/10.17826/cumj.786762