Cognitive profile in early stage Parkinson disease
Yıl: 2021 Cilt: 46 Sayı: 1 Sayfa Aralığı: 233 - 239 Metin Dili: İngilizce DOI: 10.17826/cumj.794256 İndeks Tarihi: 30-06-2021
Cognitive profile in early stage Parkinson disease
Öz: Purpose: Parkinson’s disease (PD) is a neurodegenerativedisorder characterized by both motor and nonmotorsymptoms mainly due to striatal dopamine deficiency.Cognitive dysfunction is one of nonmotor symptoms. Thepurpose of this study is to determine the cognitivedysfunction with practical screening tests and toinvestigate relationship between cognitive dysfunction andclinical severity in early stage of PD (EPD)Materials and Methods: EPD patients and healthycontrol group were included into the study. Mıni mentalstate examination (MMSE), digit span (DS), clock drawing(CD), verbal and visual memory tests were applied to allcases. Unified Parkinson’s Disease Rating Scale (UPDRS)and Hoehn & Yahr Staging (H&Y) tests were performedto EPD patients. Correlation of neurocognitive tests withUPDRS and H&Y scores were examined in EPD patients.Results: There were 30 EPD patients (11 female/19 male)and 20 healthy controls (10 female/10 male). There was asignificant difference only in CD test between EPD andhealthy controls. EPD with H&Y stage 1. group hadhigher score on backward DS, CD, and visual memorytests than EPD with H&Y stage 2. Verbal memory testscores had negatively correlated with UPDRS scores.Conclusion: The first impaired test was CD in EPDcompared to control group. Other cognitive tests(backward DS, verbal and visual memory tests) were alsoimpaired with increasing severity of disease. MMSE wasnot different from the control group and did not changewith increasing severity of disease. MMSE alone is notenough for evaluating of EPD, other cognitive tests haveto be used.
Anahtar Kelime: Erken evre Parkinson hastalığında kognitif profil
Öz: Purpose: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by both motor and nonmotor symptoms mainly due to striatal dopamine deficiency. Cognitive dysfunction is one of nonmotor symptoms. The purpose of this study is to determine the cognitive dysfunction with practical screening tests and to investigate relationship between cognitive dysfunction and clinical severity in early stage of PD (EPD) Materials and Methods: EPD patients and healthy control group were included into the study. Mıni mental state examination (MMSE), digit span (DS), clock drawing (CD), verbal and visual memory tests were applied to all cases. Unified Parkinson’s Disease Rating Scale (UPDRS) and Hoehn & Yahr Staging (H&Y) tests were performed to EPD patients. Correlation of neurocognitive tests with UPDRS and H&Y scores were examined in EPD patients. Results: There were 30 EPD patients (11 female/19 male) and 20 healthy controls (10 female/10 male). There was a significant difference only in CD test between EPD and healthy controls. EPD with H&Y stage 1. group had higher score on backward DS, CD, and visual memory tests than EPD with H&Y stage 2. Verbal memory test scores had negatively correlated with UPDRS scores. Conclusion: The first impaired test was CD in EPD compared to control group. Other cognitive tests (backward DS, verbal and visual memory tests) were also impaired with increasing severity of disease. MMSE was not different from the control group and did not change with increasing severity of disease. MMSE alone is not enough for evaluating of EPD, other cognitive tests have to be used.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | evlice a, ERDEM M, DEMIRKIRAN D (2021). Cognitive profile in early stage Parkinson disease. , 233 - 239. 10.17826/cumj.794256 |
| Chicago | evlice ahmet,ERDEM Miray,DEMIRKIRAN DURUHAN MELTEM Cognitive profile in early stage Parkinson disease. (2021): 233 - 239. 10.17826/cumj.794256 |
| MLA | evlice ahmet,ERDEM Miray,DEMIRKIRAN DURUHAN MELTEM Cognitive profile in early stage Parkinson disease. , 2021, ss.233 - 239. 10.17826/cumj.794256 |
| AMA | evlice a,ERDEM M,DEMIRKIRAN D Cognitive profile in early stage Parkinson disease. . 2021; 233 - 239. 10.17826/cumj.794256 |
| Vancouver | evlice a,ERDEM M,DEMIRKIRAN D Cognitive profile in early stage Parkinson disease. . 2021; 233 - 239. 10.17826/cumj.794256 |
| IEEE | evlice a,ERDEM M,DEMIRKIRAN D "Cognitive profile in early stage Parkinson disease." , ss.233 - 239, 2021. 10.17826/cumj.794256 |
| ISNAD | evlice, ahmet vd. "Cognitive profile in early stage Parkinson disease". (2021), 233-239. https://doi.org/10.17826/cumj.794256 |
| APA | evlice a, ERDEM M, DEMIRKIRAN D (2021). Cognitive profile in early stage Parkinson disease. Cukurova Medical Journal, 46(1), 233 - 239. 10.17826/cumj.794256 |
| Chicago | evlice ahmet,ERDEM Miray,DEMIRKIRAN DURUHAN MELTEM Cognitive profile in early stage Parkinson disease. Cukurova Medical Journal 46, no.1 (2021): 233 - 239. 10.17826/cumj.794256 |
| MLA | evlice ahmet,ERDEM Miray,DEMIRKIRAN DURUHAN MELTEM Cognitive profile in early stage Parkinson disease. Cukurova Medical Journal, vol.46, no.1, 2021, ss.233 - 239. 10.17826/cumj.794256 |
| AMA | evlice a,ERDEM M,DEMIRKIRAN D Cognitive profile in early stage Parkinson disease. Cukurova Medical Journal. 2021; 46(1): 233 - 239. 10.17826/cumj.794256 |
| Vancouver | evlice a,ERDEM M,DEMIRKIRAN D Cognitive profile in early stage Parkinson disease. Cukurova Medical Journal. 2021; 46(1): 233 - 239. 10.17826/cumj.794256 |
| IEEE | evlice a,ERDEM M,DEMIRKIRAN D "Cognitive profile in early stage Parkinson disease." Cukurova Medical Journal, 46, ss.233 - 239, 2021. 10.17826/cumj.794256 |
| ISNAD | evlice, ahmet vd. "Cognitive profile in early stage Parkinson disease". Cukurova Medical Journal 46/1 (2021), 233-239. https://doi.org/10.17826/cumj.794256 |
