Effect of tadalafil treatment on ovarian ischemia injury in rats
Yıl: 2021 Cilt: 46 Sayı: 1 Sayfa Aralığı: 55 - 62 Metin Dili: İngilizce DOI: 10.17826/cumj.784468 İndeks Tarihi: 29-06-2021
Effect of tadalafil treatment on ovarian ischemia injury in rats
Öz: Purpose: Ovarian ischemia, which is known as one of themost common gynecologic surgery emergencies in womenof all ages, is the distruption of the ovarian perfusion.Herein, we aimed to investigate the effect of tadalafil, aphosphodiesterase-5 inhibitor, at different doses anddurations in the management of ovarian survival inischemia-reperfusion injury model in rats. Materials andMaterials and Methods: Thirty female Wistar albino ratswere divided into five groups. Ovarian ischemia wasinduced by clamping the adnex of uterine tuba for threehours and reperfused for one hour. Drug treatments weregiven as follows: Group 1: saline (ischemic control), Group2: tadalafil 1 mg/kg, Group 3: tadalafil 10 mg/kg, Group4: tadalafil 1 mg/kg for 7 days, Group 5: tadalafil 10 mg/kgfor 7 days. At the end of the treatments, ovaries wereremoved and evaluated for histopathological analysis.Results: Group 4 and Group 5 showed significantdecrease in vascular congesion, hemorrhage, edema,neutrophilic infiltration compared to Group 1. All groupsshowed significant decrease in neutrophilic infiltrationcompared to Group 1. We found that treatment withtadalafil for 7 days significantly decreased the ovariantissue damage scores in rats compared to the ischemiccontrol.Conclusion: Our results showed that tadalafil treatmentin ischemic ovarian injury is effective in limiting ovariandamage. The reduction in the tissue damage scoressuggested that treatment with PDE5 inhibitors, such astadalafil, may contribute to the healing of conservativelytreated ovaries and may play a role in the treatment ofadnexal torsion
Anahtar Kelime: Tadalafil tedavisinin ratlarda over iskemi hasarına etkisi
Öz: Amaç: Her yaştan kadında en sık görülen jinekolojik cerrahi acil durumlarından biri olarak bilinen over iskemisi, yumurtalık perfüzyonunun bozulmasıdır. Sıçanlarda iskemi-reperfüzyon hasarı deneysel modelinde bir fosfodiesteraz-5 inhibitörü olan tadalafilin farklı doz ve tedavi süresinde over sağkalımı üzerindeki etkisini araştırmayı amaçladık. Gereç ve Yöntem: Otuz dişi Wistar albino sıçan beş gruba ayrıldı. Yumurtalık iskemisi, tuba uterina adneksinin üç saat klemplenmesi ve bir saat reperfüze edilmesi suretiyle gerçekleştirildi. İlaç tedavileri şu şekilde verildi: Grup 1: salin (iskemik kontrol), Grup 2: tadalafil 1 mg / kg, Grup 3: tadalafil 10 mg / kg, Grup 4: tadalafil 1 mg / kg x 7 gün, Grup 5: tadalafil 10 mg / kg x 7 gün. Tedavilerin sonunda overleri çıkarıldı ve histopatolojik olarak değerlendirildi. Bulgular: Grup 4 ve Grup 5'te, Grup 1'e kıyasla vasküler konjesyon, kanama, ödem ve nötrofilik infiltrasyon anlamlı derecede daha azdı. Tüm gruplar, Grup 1'e kıyasla nötrofilik infiltrasyonda anlamlı düşüş gösterdi. 7 günlük tadalafil tedavisinin iskemik kontrol grubu ile karşılaştırıldığında sıçanlardaki over doku hasarını belirgin derecede azalttığını tespit ettik. Sonuç: Bu çalışmadaki sonuçlar overin iskemik hasarında tadalafil tedavisinin bu hasarını sınırlamada etkili olduğunu göstermiştir. Doku hasarı skorlarındaki azalma, tadalafil gibi PDE-5 inhibitörleri ile tedavinin konservatif olarak tedavi edilen overlerin iyileşmesine katkıda bulunabileceğini ve adneksiyal torsiyonun tedavisinde rol alabileceğini ortaya koymaktadır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Altıntaş Ural D, Altıntaş Aykan D, kocarslan s, Doğaner A (2021). Effect of tadalafil treatment on ovarian ischemia injury in rats. , 55 - 62. 10.17826/cumj.784468 |
| Chicago | Altıntaş Ural Dilan,Altıntaş Aykan Duygun,kocarslan sezen,Doğaner Adem Effect of tadalafil treatment on ovarian ischemia injury in rats. (2021): 55 - 62. 10.17826/cumj.784468 |
| MLA | Altıntaş Ural Dilan,Altıntaş Aykan Duygun,kocarslan sezen,Doğaner Adem Effect of tadalafil treatment on ovarian ischemia injury in rats. , 2021, ss.55 - 62. 10.17826/cumj.784468 |
| AMA | Altıntaş Ural D,Altıntaş Aykan D,kocarslan s,Doğaner A Effect of tadalafil treatment on ovarian ischemia injury in rats. . 2021; 55 - 62. 10.17826/cumj.784468 |
| Vancouver | Altıntaş Ural D,Altıntaş Aykan D,kocarslan s,Doğaner A Effect of tadalafil treatment on ovarian ischemia injury in rats. . 2021; 55 - 62. 10.17826/cumj.784468 |
| IEEE | Altıntaş Ural D,Altıntaş Aykan D,kocarslan s,Doğaner A "Effect of tadalafil treatment on ovarian ischemia injury in rats." , ss.55 - 62, 2021. 10.17826/cumj.784468 |
| ISNAD | Altıntaş Ural, Dilan vd. "Effect of tadalafil treatment on ovarian ischemia injury in rats". (2021), 55-62. https://doi.org/10.17826/cumj.784468 |
| APA | Altıntaş Ural D, Altıntaş Aykan D, kocarslan s, Doğaner A (2021). Effect of tadalafil treatment on ovarian ischemia injury in rats. Cukurova Medical Journal, 46(1), 55 - 62. 10.17826/cumj.784468 |
| Chicago | Altıntaş Ural Dilan,Altıntaş Aykan Duygun,kocarslan sezen,Doğaner Adem Effect of tadalafil treatment on ovarian ischemia injury in rats. Cukurova Medical Journal 46, no.1 (2021): 55 - 62. 10.17826/cumj.784468 |
| MLA | Altıntaş Ural Dilan,Altıntaş Aykan Duygun,kocarslan sezen,Doğaner Adem Effect of tadalafil treatment on ovarian ischemia injury in rats. Cukurova Medical Journal, vol.46, no.1, 2021, ss.55 - 62. 10.17826/cumj.784468 |
| AMA | Altıntaş Ural D,Altıntaş Aykan D,kocarslan s,Doğaner A Effect of tadalafil treatment on ovarian ischemia injury in rats. Cukurova Medical Journal. 2021; 46(1): 55 - 62. 10.17826/cumj.784468 |
| Vancouver | Altıntaş Ural D,Altıntaş Aykan D,kocarslan s,Doğaner A Effect of tadalafil treatment on ovarian ischemia injury in rats. Cukurova Medical Journal. 2021; 46(1): 55 - 62. 10.17826/cumj.784468 |
| IEEE | Altıntaş Ural D,Altıntaş Aykan D,kocarslan s,Doğaner A "Effect of tadalafil treatment on ovarian ischemia injury in rats." Cukurova Medical Journal, 46, ss.55 - 62, 2021. 10.17826/cumj.784468 |
| ISNAD | Altıntaş Ural, Dilan vd. "Effect of tadalafil treatment on ovarian ischemia injury in rats". Cukurova Medical Journal 46/1 (2021), 55-62. https://doi.org/10.17826/cumj.784468 |
