THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES
Yıl: 2020 Cilt: 83 Sayı: 4 Sayfa Aralığı: 378 - 383 Metin Dili: İngilizce DOI: 10.26650/IUITFD.2020.0079 İndeks Tarihi: 09-06-2021
THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES
Öz: Objective: In this study, we aimed to predict the malignancy potential of a thyroid nodule based on ultrasonography (US) features.Material and Method: The data of 726 nodules in 619 patientswho underwent thyroidectomy between 2005 and 2012 at Istanbul University, Istanbul Medical Faculty were retrospectivelyanalyzed. US features of nodules were recorded and matchedwith pathology reports and each US feature was evaluated fordiagnostic value.Results: The study group consisted of mainly female patients(86.9%) and the mean age was 46,3 years. Thyroid cancer wasdetected in 374 (51.7%) nodules and the most common typewas papillary thyroid cancer 97% (n=341). Microcalcifications(p=0.0001), irregular margin (p=0.001) and hypoechogenicity(p=0.038) were correlated with malignancy. The absence of anyof these suspicious US features significantly predicted benigndisease (p=0.0001). An increasing number of suspicious featurespredicted malign disease with increasing specificity, positive predictive value, and likelihood ratio. Microcalcifications and irregular borders had high specificity (>80%) to predict thyroid cancer.Conclusion: The presence of microcalcifications, irregular margin, and hypoechogenicity in a thyroid nodule significantly correlates with malignant disease. Microcalcifications and irregularborders had high specificity to predict thyroid cancer. The probability of thyroid cancer increases with an increasing number ofsuspicious US features.
Anahtar Kelime: POTANSİYEL MALİGN TİROİD NODÜLLERİ İÇİN ULTRASONOGRAFİNİN TAHMİN DEĞERİ
Öz: Amaç: Bu çalışmada tiroid nodüllerindeki malignite olasılığını ultrasonografi (US) özelliklerinin öngörme seviyesini araştırmayı amaçladık. Gereç ve Yöntem: İstanbul Üniversitesi İstanbul Tıp Fakültesi’nde, 2005 ila 2012 yılları arasında total tiroidektomi ameliyatı olan 619 hastada 726 nodül geriye dönük olarak incelendi. Tiroid nodüllerinin US özellikleri kaydedildi, patoloji raporları ile karşılaştırılarak eşleştirildi ve US özelliklerin tanısal değeri hesaplandı. Bulgular: Çalışmaya alınan hastalarda kadın oranı (%86,9) olup, ortalama yaş 46,3 olarak hesaplandı. Tiroid kanseri 374 (%51,7) nodülde tespit edilirken, en sık kanser türü %97 (n=341) oranla papiller tiroid kanseriydi. Tiroid nodülünde mikrokalsifikasyon (p=0,0001), düzensiz sınır (p=0,001) ve hipoekojenite (p=0,038) varlığı malignite ile korelasyon gösterdi. Mikrokalsifikasyon ve düzensiz sınır özelliklerinin kanser öngörüsü bakımından özgüllüğü yüksek (>%80) bulundu. Nodülde bu şüpheli US özelliklerinden hiçbirinin olmaması selim hastalığı (p=0,0001) tahmin etti. Artan US şüpheli özelliklerin sayısı, artan özgüllük, pozitif prediktif değer ve olasılık oranı ile malign hastalığı öngördü. Mikro kalsifikasyonlar ve düzensiz sınır tiroid kanserini öngörmek için yüksek özgüllüğe (>%80) sahipti. Sonuç: Bir tiroid nodülünde mikrokalsifikasyon, düzensiz sınır ve hipoekojenite varlığında tiroid kanseri olasılığı anlamlı şekilde yüksektir. Malignite öngörüsü açısından özgüllüğü en yüksek bulgular mikrokalsifikasyon ve düzensiz sınırdır. Bir nodüldeki şüpheli US özelliklerinin sayısı arttıkça malignite olasılığı da paralel olarak anlamlı şekilde artar
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Ozgur I, Iscan Y, Sormaz İ, Tunca F, Salmaslioglu A, Bayram A, Yegen G, şenyürek y (2020). THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES. , 378 - 383. 10.26650/IUITFD.2020.0079 |
| Chicago | Ozgur Ilker,Iscan Yalin,Sormaz İsmail Cem,Tunca Fatih,Salmaslioglu Artur,Bayram Aysel,Yegen Gulcin,şenyürek yasemin THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES. (2020): 378 - 383. 10.26650/IUITFD.2020.0079 |
| MLA | Ozgur Ilker,Iscan Yalin,Sormaz İsmail Cem,Tunca Fatih,Salmaslioglu Artur,Bayram Aysel,Yegen Gulcin,şenyürek yasemin THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES. , 2020, ss.378 - 383. 10.26650/IUITFD.2020.0079 |
| AMA | Ozgur I,Iscan Y,Sormaz İ,Tunca F,Salmaslioglu A,Bayram A,Yegen G,şenyürek y THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES. . 2020; 378 - 383. 10.26650/IUITFD.2020.0079 |
| Vancouver | Ozgur I,Iscan Y,Sormaz İ,Tunca F,Salmaslioglu A,Bayram A,Yegen G,şenyürek y THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES. . 2020; 378 - 383. 10.26650/IUITFD.2020.0079 |
| IEEE | Ozgur I,Iscan Y,Sormaz İ,Tunca F,Salmaslioglu A,Bayram A,Yegen G,şenyürek y "THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES." , ss.378 - 383, 2020. 10.26650/IUITFD.2020.0079 |
| ISNAD | Ozgur, Ilker vd. "THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES". (2020), 378-383. https://doi.org/10.26650/IUITFD.2020.0079 |
| APA | Ozgur I, Iscan Y, Sormaz İ, Tunca F, Salmaslioglu A, Bayram A, Yegen G, şenyürek y (2020). THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES. İstanbul Tıp Fakültesi Dergisi, 83(4), 378 - 383. 10.26650/IUITFD.2020.0079 |
| Chicago | Ozgur Ilker,Iscan Yalin,Sormaz İsmail Cem,Tunca Fatih,Salmaslioglu Artur,Bayram Aysel,Yegen Gulcin,şenyürek yasemin THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES. İstanbul Tıp Fakültesi Dergisi 83, no.4 (2020): 378 - 383. 10.26650/IUITFD.2020.0079 |
| MLA | Ozgur Ilker,Iscan Yalin,Sormaz İsmail Cem,Tunca Fatih,Salmaslioglu Artur,Bayram Aysel,Yegen Gulcin,şenyürek yasemin THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES. İstanbul Tıp Fakültesi Dergisi, vol.83, no.4, 2020, ss.378 - 383. 10.26650/IUITFD.2020.0079 |
| AMA | Ozgur I,Iscan Y,Sormaz İ,Tunca F,Salmaslioglu A,Bayram A,Yegen G,şenyürek y THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES. İstanbul Tıp Fakültesi Dergisi. 2020; 83(4): 378 - 383. 10.26650/IUITFD.2020.0079 |
| Vancouver | Ozgur I,Iscan Y,Sormaz İ,Tunca F,Salmaslioglu A,Bayram A,Yegen G,şenyürek y THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES. İstanbul Tıp Fakültesi Dergisi. 2020; 83(4): 378 - 383. 10.26650/IUITFD.2020.0079 |
| IEEE | Ozgur I,Iscan Y,Sormaz İ,Tunca F,Salmaslioglu A,Bayram A,Yegen G,şenyürek y "THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES." İstanbul Tıp Fakültesi Dergisi, 83, ss.378 - 383, 2020. 10.26650/IUITFD.2020.0079 |
| ISNAD | Ozgur, Ilker vd. "THE PREDICTIVE VALUE OF ULTRASONOGRAPHY FOR POTENTIALLY MALIGNANT THYROID NODULES". İstanbul Tıp Fakültesi Dergisi 83/4 (2020), 378-383. https://doi.org/10.26650/IUITFD.2020.0079 |
