Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?

EYIGOR, METE; SELCUK, OMER; Renda, Levent; IŞIK, Ünal Gökalp; Eyigör, Hülya; KONŞUK ÜNLÜ, Hande; Gultekin, Meral; turkoglu selcuk, nursel; Osma, Üstün; İLDEN, Oguzhan; yılmaz, mustafa deniz

doi:10.5606/Tr-ENT.2020.91885

Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?

Üstün OSMA, (Antalya Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Anabilim Dalı, Antalya, Türkiye)

Ömer Tarık SELÇUK, (Antalya Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Anabilim Dalı, Antalya, Türkiye)

Mete EYİGÖR, (Akdeniz Üniversitesi, Tıp Fakültesi, Mikrobiyoloji Anabilim Dalı, Antalya, Türkiye)

Levent RENDA, (Antalya Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Anabilim Dalı, Antalya, Türkiye)

Nursel TÜRKOĞLU SELÇUK, (Antalya Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları ve Uyku Anabilim Dalı, Antalya, Türkiye)

Hülya EYİGÖR, (Antalya Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Anabilim Dalı, Antalya, Türkiye)

M. Deniz YILMAZ, (Antalya Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Anabilim Dalı, Antalya, Türkiye)

Oğuzhan İLDEN, (Antalya Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Anabilim Dalı, Antalya, Türkiye)

Ünal Gökalp IŞIK, (Antalya Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Anabilim Dalı, Antalya, Türkiye)

Hande KONŞUK ÜNLÜ, (Hacettepe Üniversitesi, Halk Sağlığı Enstitüsü, Ankara, Türkiye)

Meral GÜLTEKIN, (Akdeniz Üniversitesi, Tıp Fakültesi, Mikrobiyoloji Anabilim Dalı, Antalya, Türkiye)

Diğer Yazarlar

The Turkish Journal of Ear Nose and Throat

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Yıl: 2020 Cilt: 30 Sayı: 2 Sayfa Aralığı: 52 - 57 Metin Dili: İngilizce DOI: 10.5606/Tr-ENT.2020.91885 İndeks Tarihi: 10-06-2021

Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?

Öz:

Objectives: The aim of this study was to evaluate serum copeptin levels in patients with obstructive sleep apnea (OSA) before and after the positive airway pressure (PAP) treatment.Patients and Methods: A total of 16 patients (14 males, 2 females; median age 48 years; range, 38 to 60 years) with severe sleep apnea based on the Apnea Hypopnea Index (AHI) >30 and 20 healthy controls (10 males, 10 females; median age 35.5 years; range, 22 to 47 years) were included in this study between October 2014 and December 2015. Full-night polysomnography was applied to each patient. Serum copeptin levels were determined using the enzyme-linked immunosorbent assay in both groups. Serum copeptin level measurement was repeated in the patient group after one year of PAP treatment.Results: After one year of PAP treatment, serum copeptin levels of the patients with OSA decreased, although there was no statistically significant difference before and after treatment.Conclusion: Increased serum copeptin concentration may reflect a response to moderate stress in many diseases, particularly cardiovascular diseases. Based on our study results, there was no significant difference between the severe OSA group and healthy volunteers and before and after treatment among the patients with severe OSA.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Dyken ME, Im KB. Obstructive sleep apnea and stroke. Chest 2009;136:1668-77.
2. Tuomilehto H, Seppä J, Uusitupa M. Obesity and obstructive sleep apnea--clinical significance of weight loss Sleep Med Rev 2013;17:321-9.
3. Quercioli A, Mach F, Montecucco F. Inflammation accelerates atherosclerotic processes in obstructive sleep apnea syndrome (OSAS). Sleep Breath 2010;14:261-9.
4. Ozben S, Guvenc TS, Huseyinoglu N, Sanivar HS, Hanikoglu F, Cort A, et al. Low serum copeptin levels in patients with obstructive sleep apnea. Sleep Breath 2013;17:1187-92.
5. Yalta K, Yalta T, Sivri N, Yetkin E. Copeptin and cardiovascular disease: a review of a novel neurohormone. Int J Cardiol 2013;167:1750-9.
6. Katan M, Morgenthaler N, Widmer I, Puder JJ, König C, Müller B, et al. Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level. Neuro Endocrinol Lett 2008;29:341-6.
7. Selcuk OT, Eyigor M, Renda L, Osma U, Eyigor H, Selcuk NT, et al. Can we use serum copeptin levels as a biomarker in obstructive sleep apnea syndrome? J Craniomaxillofac Surg 2015;43:879-82.
8. Çınarka H, Kayhan S, Karataş M, Yavuz A, Gümüş A, Özyurt S, et al. Copeptin: a new predictor for severe obstructive sleep apnea. Ther Clin Risk Manag 2015;11:589-94.
9. Izci B, Ardic S, Firat H, Sahin A, Altinors M, Karacan I. Reliability and validity studies of the Turkish version of the Epworth Sleepiness Scale. Sleep Breath 2008;12:161-8.
10. Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med 2012;8:597-619.
11. Kiely JL, McNicholas WT. Cardiovascular risk factors in patients with obstructive sleep apnoea syndrome. Eur Respir J 2000;16:128-33.
12. Yalta K, Sıvrı N, Yalta T, Geyik B, Aksoy Y, Yetkın E. Copeptin (C-terminal provasopressin): a promising marker of arrhythmogenesis in arrhythmia prone subjects? Int J Cardiol 2011;148:105.
13. Seligman R, Ramos-Lima LF, Oliveira Vdo A, Sanvicente C, Pacheco EF, Dalla Rosa K. Biomarkers in community-acquired pneumonia: a state-of-the-art review. Clinics (Sao Paulo) 2012;67:1321-5.
14. Itoi K, Jiang YQ, Iwasaki Y, Watson SJ. Regulatory mechanisms of corticotropin-releasing hormone and vasopressin gene expression in the hypothalamus. J Neuroendocrinol 2004;16:348-55.
15. Voors AA, von Haehling S, Anker SD, Hillege HL, Struck J, Hartmann O, et al. C-terminal provasopressin (copeptin) is a strong prognostic marker in patients with heart failure after an acute myocardial infarction: results from the OPTIMAAL study. Eur Heart J 2009;30:1187-94.
16. Katan M, Müller B, Christ-Crain M. Copeptin: a new and promising diagnostic and prognostic marker. Crit Care 2008;12:117.
17. Christ-Crain M, Müller B. Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators. Eur Respir J 2007;30:556-73.

APA	Osma Ü, SELCUK O, EYIGOR M, Renda L, turkoglu selcuk n, Eyigör H, yılmaz m, İLDEN O, IŞIK Ü, KONŞUK ÜNLÜ H, Gultekin M (2020). Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?. , 52 - 57. 10.5606/Tr-ENT.2020.91885
Chicago	Osma Üstün,SELCUK OMER,EYIGOR METE,Renda Levent,turkoglu selcuk nursel,Eyigör Hülya,yılmaz mustafa deniz,İLDEN Oguzhan,IŞIK Ünal Gökalp,KONŞUK ÜNLÜ Hande,Gultekin Meral Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?. (2020): 52 - 57. 10.5606/Tr-ENT.2020.91885
MLA	Osma Üstün,SELCUK OMER,EYIGOR METE,Renda Levent,turkoglu selcuk nursel,Eyigör Hülya,yılmaz mustafa deniz,İLDEN Oguzhan,IŞIK Ünal Gökalp,KONŞUK ÜNLÜ Hande,Gultekin Meral Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?. , 2020, ss.52 - 57. 10.5606/Tr-ENT.2020.91885
AMA	Osma Ü,SELCUK O,EYIGOR M,Renda L,turkoglu selcuk n,Eyigör H,yılmaz m,İLDEN O,IŞIK Ü,KONŞUK ÜNLÜ H,Gultekin M Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?. . 2020; 52 - 57. 10.5606/Tr-ENT.2020.91885
Vancouver	Osma Ü,SELCUK O,EYIGOR M,Renda L,turkoglu selcuk n,Eyigör H,yılmaz m,İLDEN O,IŞIK Ü,KONŞUK ÜNLÜ H,Gultekin M Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?. . 2020; 52 - 57. 10.5606/Tr-ENT.2020.91885
IEEE	Osma Ü,SELCUK O,EYIGOR M,Renda L,turkoglu selcuk n,Eyigör H,yılmaz m,İLDEN O,IŞIK Ü,KONŞUK ÜNLÜ H,Gultekin M "Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?." , ss.52 - 57, 2020. 10.5606/Tr-ENT.2020.91885
ISNAD	Osma, Üstün vd. "Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?". (2020), 52-57. https://doi.org/10.5606/Tr-ENT.2020.91885

APA	Osma Ü, SELCUK O, EYIGOR M, Renda L, turkoglu selcuk n, Eyigör H, yılmaz m, İLDEN O, IŞIK Ü, KONŞUK ÜNLÜ H, Gultekin M (2020). Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?. The Turkish Journal of Ear Nose and Throat, 30(2), 52 - 57. 10.5606/Tr-ENT.2020.91885
Chicago	Osma Üstün,SELCUK OMER,EYIGOR METE,Renda Levent,turkoglu selcuk nursel,Eyigör Hülya,yılmaz mustafa deniz,İLDEN Oguzhan,IŞIK Ünal Gökalp,KONŞUK ÜNLÜ Hande,Gultekin Meral Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?. The Turkish Journal of Ear Nose and Throat 30, no.2 (2020): 52 - 57. 10.5606/Tr-ENT.2020.91885
MLA	Osma Üstün,SELCUK OMER,EYIGOR METE,Renda Levent,turkoglu selcuk nursel,Eyigör Hülya,yılmaz mustafa deniz,İLDEN Oguzhan,IŞIK Ünal Gökalp,KONŞUK ÜNLÜ Hande,Gultekin Meral Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?. The Turkish Journal of Ear Nose and Throat, vol.30, no.2, 2020, ss.52 - 57. 10.5606/Tr-ENT.2020.91885
AMA	Osma Ü,SELCUK O,EYIGOR M,Renda L,turkoglu selcuk n,Eyigör H,yılmaz m,İLDEN O,IŞIK Ü,KONŞUK ÜNLÜ H,Gultekin M Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?. The Turkish Journal of Ear Nose and Throat. 2020; 30(2): 52 - 57. 10.5606/Tr-ENT.2020.91885
Vancouver	Osma Ü,SELCUK O,EYIGOR M,Renda L,turkoglu selcuk n,Eyigör H,yılmaz m,İLDEN O,IŞIK Ü,KONŞUK ÜNLÜ H,Gultekin M Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?. The Turkish Journal of Ear Nose and Throat. 2020; 30(2): 52 - 57. 10.5606/Tr-ENT.2020.91885
IEEE	Osma Ü,SELCUK O,EYIGOR M,Renda L,turkoglu selcuk n,Eyigör H,yılmaz m,İLDEN O,IŞIK Ü,KONŞUK ÜNLÜ H,Gultekin M "Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?." The Turkish Journal of Ear Nose and Throat, 30, ss.52 - 57, 2020. 10.5606/Tr-ENT.2020.91885
ISNAD	Osma, Üstün vd. "Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructivesleep apnea?". The Turkish Journal of Ear Nose and Throat 30/2 (2020), 52-57. https://doi.org/10.5606/Tr-ENT.2020.91885