Yıl: 2020 Cilt: 9 Sayı: 3 Sayfa Aralığı: 267 - 271 Metin Dili: İngilizce İndeks Tarihi: 15-06-2021

Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer

Öz:
Prostate cancer is a common type of cancer amongmen. Recently, studies on new anticancer agents ofherbal origin in the treatment of cancer haveincreased. Haplophyllum buxbaumii (HP) is aperennial herbaceous plant. Studies have reported thatHaplophyllum subspecies has antioxidant properties.And the anticancer effect of HP is unknown. Thisstudy aims to reveal the apoptotic effect HP onprostate cancer. The cytotoxic effect of HP wasevaluated by the MTT method. In addition, apoptoticpathway mediators were analyzed by ELISA method.HP extract application reduced the viability ofprostate cancer and activated the apoptotic mediatorswhile decreasing anti-apoptotic mediators. Our studyshowed that HP extract has an antiproliferative andapoptotic effect on prostate cancer.
Anahtar Kelime:

Haplophyllum Buxbaumii Ekstresinin Prostat Kanseri Üzerindeki Apoptotik Etkisi

Öz:
Prostat kanseri, erkekler arasında yaygın bir kanser türüdür. Son zamanlarda, kanser tedavisinde bitkisel kökenli yeni antikanser ajanlar üzerine yapılan çalışmalar artmıştır. Haplophyllum buxbaumii (HP) çok yıllık otsu bir bitkidir. Çalışmalar, Haplophyllum alt türlerinin antioksidan özelliklere sahip olduğunu bildirmiştir. HP'nin antikanser etkisi bilinmemektedir. Bu çalışma, HP'nin prostat kanseri üzerindeki apoptotik etkisini ortaya çıkarmayı amaçlamaktadır. HP'nin sitotoksik etkisi MTT yöntemi ile değerlendirilmiştir. Ayrıca apoptotik yol aracı medyatörleri ELISA yöntemi ile analiz edilmiştir. HP ekstresi uygulaması, prostat kanserinin canlılığını azaltıp apoptopik medyatörleri aktive ederken aynı zamanda antiapoptopik mediyatörleri azaltmıştır. Çalışmamız, HP ekstresinin prostat kanseri üzerinde antiproliferatif ve apoptotik bir etkiye sahip olduğunu göstermiştir
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. No authors listed. (2013). "Locally Advanced Prostate Cancer: Effective Treatments, But Many Adverse Effects". Prescrire Int., 22 (134), 18-20, 22-3 (ISSN: 1167-7422). https://pubmed. ncbi.nlm.nih.gov/23367679/.
  • 2. Miranda-Goncalves, V., Lameirinhas, A., Henrique, R. and Jeronimo, C. (2019) "Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets". Frontiers in Genetics, 9 (10), 1-21.
  • 3. Prieto, J.M., Recio, M.C., Giner, R.M, Manez, S., Massmanian, A., Waterman, P.G. and Rios, J.L. (1996). "Topical Anti-Inflammatory Lignans From Haplophyllum Hispanicum". Biosci, 51 (9-10), 618-622.
  • 4. Kaplan, H.M., Singirik, E., Erdogan, K.E. and Doran, F. (2017). "Protective Effect of Alpha-Linolenic Acid on Gentamicin-Induced Ototoxicity in Mice". Somatosens Mot Res., 34 (3), 145-150.
  • 5. Kaplan, H.M., Izol, V., Aridogan, I.A., Olgan, E., Yegani, A.A., Pazarci, P. and Singirik, E. (2016). "Protective Effect of Hypericum Perforatum Extract on Gentamicin Induced Nephrotoxicity in Mice." Int J Pharmacol, 12 (6), 663- 668.
  • 6. Izol, V., Aridogan, I.A., Tansug, Z., Doran, F., Erdogan, K.E., Kaplan, H.M., Singirik, E., Ertug, P. and Pazarci, P. (2019). "Hypericum Perforatum Extract Attennuates Gentamicin Induced Oxidative Stress, Apoptosis and Oedema in Kidney". Int J Pharmacol, 15 (1), 66-73.
  • 7. Choromanska, A., Kulbacka, J., Harasym, J., DubinskaMagiera, M. and Saczko, J. (2017). "Anticancer Activity of Oat Β-Glucan in Combination with Electroporation on Human Cancer Cells". Acta Pol. Pharm. Drug Res, 74, 616-623.
  • 8. Kocyigit, A., Koyuncu, I., Dikilitas, M., Bahadori, F. and Turkkan, B. (2016). "Cytotoxic, Genotoxic and Apoptotic Effects of Naringenin-Oxime Relative to Naringenin on Normal and Cancer Cell Lines". Asian Pac J Trop Bio, 6 (10), 872-880.
  • 9. Buyel, J.F. (2018). "Plants As Sources of Natural and Recombinant Anti-Cancer Agents". Biotechnology Advances, 36 (2), 506-520.
  • 10. Jain, K.K. (2007). "Cancer Biomarkers: Current Issues and Future Directions". Curr Opin Mol Ther, 9 (6), 563-571.
  • 11. Sun, .J., Wei, Q., Zhou, Y., Wang, J., Liu, Q. and Xu, H. (2017). "A Systematic Analysis of FDA-Approved Anticancer Drugs". BMC Systems Biology, 11 (Suppl 5), 27-42.
APA Kazimoglu H, kaplan h (2020). Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer. , 267 - 271.
Chicago Kazimoglu Hatem,kaplan halil mahir Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer. (2020): 267 - 271.
MLA Kazimoglu Hatem,kaplan halil mahir Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer. , 2020, ss.267 - 271.
AMA Kazimoglu H,kaplan h Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer. . 2020; 267 - 271.
Vancouver Kazimoglu H,kaplan h Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer. . 2020; 267 - 271.
IEEE Kazimoglu H,kaplan h "Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer." , ss.267 - 271, 2020.
ISNAD Kazimoglu, Hatem - kaplan, halil mahir. "Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer". (2020), 267-271.
APA Kazimoglu H, kaplan h (2020). Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 9(3), 267 - 271.
Chicago Kazimoglu Hatem,kaplan halil mahir Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 9, no.3 (2020): 267 - 271.
MLA Kazimoglu Hatem,kaplan halil mahir Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, vol.9, no.3, 2020, ss.267 - 271.
AMA Kazimoglu H,kaplan h Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi. 2020; 9(3): 267 - 271.
Vancouver Kazimoglu H,kaplan h Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi. 2020; 9(3): 267 - 271.
IEEE Kazimoglu H,kaplan h "Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer." Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 9, ss.267 - 271, 2020.
ISNAD Kazimoglu, Hatem - kaplan, halil mahir. "Apoptotic Effect of Haplophyllum Buxbaumii Extract on Prostate Cancer". Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 9/3 (2020), 267-271.