Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?

BÜYÜK, Gül Nihal; Engin-Ustun, Yaprak; Ozgu-Erdinc, A. Seval; sert, Umit yasemin

doi:10.5222/MMJ.2020.29964

Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?

Yaprak ENGİN ÜSTÜN, (Sağlık Bilimleri Üniversitesi, Zekai Tahir Burak Kadın Sağlık Eğitimi ve Araştırması Hastane, Bölümü Kadın Hastalıkları ve Doğum, Ankara Türkiye)

A. Seval ÖZGÜ ERDİNÇ (Sağlık Bilimleri Üniversitesi, Zekai Tahir Burak Kadın Sağlık Eğitimi ve Araştırması Hastane, Bölümü Kadın Hastalıkları ve Doğum, Ankara Türkiye)

Medeniyet Medical Journal

3 0

Yıl: 2020 Cilt: 35 Sayı: 3 Sayfa Aralığı: 195 - 201 Metin Dili: İngilizce DOI: 10.5222/MMJ.2020.29964 İndeks Tarihi: 14-06-2021

Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?

Öz:

Objective: To determine the levels of thyroid-stimulating hormone (TSH), thyroxin (T4), triiodothyronine (T3), anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG) and renal iodine excretion (RIE) in the first trimester of the pregnancy and to estimate the risk of developingGDM in these patients.Method: The levels of TSH, T3, T4, anti-TPO, anti-TG, and RIE were retrospectively evaluated. Atotal of 312 pregnant women were included in the study (GDM (-) group n=240, GDM (+) groupn=62). Diagnosis of GDM was made according to the recommendation of American DiabetesOrganization (ADA). The association between thyroid dysfunction and GDM was evaluated.Results: Our study included a total of 302 women. Sixty-two of these women were diagnosedas GDM (62/302=20.5%). When compared with the GDM (-) group the mean TSH level (2.02 vs4.13 p=0.019), anti-TPO positivity (8.3% vs 30.64% p=0.044), anti-TG positivity (8.3% vs 19.4%p=0.019) and RIE (156 vs 178 p=0.017) were significantly higher in the GDM (+) group. TSHlevels were statistically significantly higher in patients with positive anti-TPO levels (P=0.045).Conclusion: Elevated TSH levels , TPO and TG antibody positivity rates were more frequentamong the patients with GDM. These results may be a guide to perform routine thyroid functiontests for patients with increased risk of GDM, on the other hand, they will alert the physicians forGDM progression and ensure taking preventive attempts for the patients who have thyroid disorder, especially those with positive thyroid antibodies in the first trimester of the pregnancy

Anahtar Kelime:

Gebelikte Tiroid Fonksiyon Bozuklukları, Tiroid Antikorları ve Gestasyonel Diabetes Mellitus (GDM) Gelişimi Arasında Bir İlişki Var Mıdır?

Öz:

Amaç: Gebeliğin ilk trimesterında tiroid stimule edici hormon (TSH), tiroksin (T3), triiodotironin (T3), anti- tiroid peroksidaz (anti-TPO), anti tiroglobulin (anti-TG) ve renal iyot atılımını (RIA) saptamak ve bu hastalarda gestasyonel diyabet (GDM) gelişme riskini belirlemek. Yöntem: TSH, T3, T4, anti-TPO, anti-TG ve üriner iyot atılımı düzeyleri retrospektif olarak değerlendirildi. Toplamda 302 kadın çalışmaya dahil edildi (GDM (-) grup n=240, GDM (+) grup n=62). GDM tanısı Amerikan Diyabet Derneğinin (American Diabetes Organization (ADA) önerileri doğrultusunda yapıldı. Tiroid disfonksiyonu ve GDM arasındaki ilişki değerlendirildi. Bulgular: Çalışmamıza toplamda 302 kadın dahil edildi. Bu kadınlardan altmış ikisi GDM tanısı aldı (62/302=%20.5). Ortalama TSH düzeyi (2.02 vs 4.13 p=0.019), anti-TPO (8.3% vs 30.64% p=0.044), anti-TG pozitifliği (8.3% vs 19.4% p=0.01) ve RIA düzeyleri (156 vs 178 p=0.017) GDM (+) saptanan grupda anlamlı olarak yüksek saptandı TSH, anti-TPO pozitif olan kadınlarda daha yüksek olma eğiliminde olup, bu fark istatistiksel olarak anlamlı saptandı (P=0.045). Sonuç: Artmış TSH düzeyi ve anti-TPO, TG antikor pozitifliği GDM’li hastalarda daha sık olarak gözlenir. Çalışmamızın sonuçları, artmış GDM riski olan hastalarda rutin tiroid fonksiyon testi ile değerlendirme konusunda yol gösterici olacak, diğer taraftan, gebelikte tiroid fonksiyon bozukluğu, özellikle ilk trimester’da tiroid antikor pozitifliği olan hastalarda GDM gelişimi açısından dikkatli olunması ve önleyici adımların atılması sağlanacaktır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	sert U, BÜYÜK G, Engin-Ustun Y, Ozgu-Erdinc A (2020). Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?. , 195 - 201. 10.5222/MMJ.2020.29964
Chicago	sert Umit yasemin,BÜYÜK Gül Nihal,Engin-Ustun Yaprak,Ozgu-Erdinc A. Seval Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?. (2020): 195 - 201. 10.5222/MMJ.2020.29964
MLA	sert Umit yasemin,BÜYÜK Gül Nihal,Engin-Ustun Yaprak,Ozgu-Erdinc A. Seval Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?. , 2020, ss.195 - 201. 10.5222/MMJ.2020.29964
AMA	sert U,BÜYÜK G,Engin-Ustun Y,Ozgu-Erdinc A Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?. . 2020; 195 - 201. 10.5222/MMJ.2020.29964
Vancouver	sert U,BÜYÜK G,Engin-Ustun Y,Ozgu-Erdinc A Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?. . 2020; 195 - 201. 10.5222/MMJ.2020.29964
IEEE	sert U,BÜYÜK G,Engin-Ustun Y,Ozgu-Erdinc A "Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?." , ss.195 - 201, 2020. 10.5222/MMJ.2020.29964
ISNAD	sert, Umit yasemin vd. "Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?". (2020), 195-201. https://doi.org/10.5222/MMJ.2020.29964

APA	sert U, BÜYÜK G, Engin-Ustun Y, Ozgu-Erdinc A (2020). Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?. Medeniyet Medical Journal, 35(3), 195 - 201. 10.5222/MMJ.2020.29964
Chicago	sert Umit yasemin,BÜYÜK Gül Nihal,Engin-Ustun Yaprak,Ozgu-Erdinc A. Seval Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?. Medeniyet Medical Journal 35, no.3 (2020): 195 - 201. 10.5222/MMJ.2020.29964
MLA	sert Umit yasemin,BÜYÜK Gül Nihal,Engin-Ustun Yaprak,Ozgu-Erdinc A. Seval Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?. Medeniyet Medical Journal, vol.35, no.3, 2020, ss.195 - 201. 10.5222/MMJ.2020.29964
AMA	sert U,BÜYÜK G,Engin-Ustun Y,Ozgu-Erdinc A Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?. Medeniyet Medical Journal. 2020; 35(3): 195 - 201. 10.5222/MMJ.2020.29964
Vancouver	sert U,BÜYÜK G,Engin-Ustun Y,Ozgu-Erdinc A Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?. Medeniyet Medical Journal. 2020; 35(3): 195 - 201. 10.5222/MMJ.2020.29964
IEEE	sert U,BÜYÜK G,Engin-Ustun Y,Ozgu-Erdinc A "Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?." Medeniyet Medical Journal, 35, ss.195 - 201, 2020. 10.5222/MMJ.2020.29964
ISNAD	sert, Umit yasemin vd. "Is There Any Relationship Between Thyroid Function Abnormalities, Thyroid Antibodies and Development of Gestational Diabetes Mellitus (GDM) in Pregnant Women?". Medeniyet Medical Journal 35/3 (2020), 195-201. https://doi.org/10.5222/MMJ.2020.29964