(Antalya Eğitim ve Araştırma Hastanesi, İç Hastalıkları Anabilim Dalı, Hematoloji Bilim Dalı, Antalya, Türkiye)
(Antalya Eğitim ve Araştırma Hastanesi, İç Hastalıkları Anabilim Dalı, Hematoloji Bilim Dalı, Antalya, Türkiye)
Yıl: 2021Cilt: 14Sayı: 2ISSN: 1309-9833 / 1308-0865Sayfa Aralığı: 322 - 329İngilizce

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Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response
Purpose: Ruxolitinib is an oral JAK-1/2 inhibitor approved for the treatment of splenomegaly and/or constitutionalsymptoms in intermediate and high-risk myelofibrosis patients. The aim of our study is to evaluate the efficacyand safety of ruxolitinib in primary MF, post-ET MF and post-PV MF patients, to evaluate the relationshipbetween response and JAK-2 allele burden and to compare them with literature data.Materials and methods: In our single centered and retrospective study, we investigated the data of 30 MFpatients diagnosed in our clinic between May 2015 and December 2019. We reported demographic features,laboratory values, and spleen sizes.Results: 18 patients (60%) with a median age of 67.5 (45-78) had primary myelofibrosis. Spleen sizes decreasedsignificantly 3 and 6 months after treatment. Constitutional symptoms have disappeared in 28 patients (93.3%).No association was found between JAK-2 allele burden and treatment response success.Conclusion: Ruxolitinib MF is very safe and effective to relieve constitutional symptoms and decrease spleensize. Despite JAK-2 inhibition, no linear relationship was found between JAK-2 allele burden and treatmentefficacy.
DergiAraştırma MakalesiErişime Açık
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