Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis
Yıl: 2021 Cilt: 14 Sayı: 2 Sayfa Aralığı: 452 - 459 Metin Dili: İngilizce DOI: 10.31362/patd.748871 İndeks Tarihi: 29-07-2022
Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis
Öz: Purpose: Psoriasis is a chronic, inflammatory, and systemic disease. The disease activity is usually measuredby Psoriasis Area and Severity Index (PASI), however, further objective laboratory tools are needed. Neutrophillymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and mean platelet volume (MPV) are objectivelycalculated markers that increase in inflammation. This study aimed to investigate the utility of these markers forfollow-up of systemic inflammation and response to treatment.Material and methods: A total of 25 patients who had moderate or severe psoriasis vulgaris, who receivedustekinumab treatment were retrospectively evaluated in the study. In patients, pre-treatment PASI, completeblood count parameters, serum CRP levels and NLR, PLR and MPV values in the follow up when theyachieved PASI 75 and/or more improvement were recorded. Patients with an additional inflammatory disease oraccompanying infection were excluded from the study.Results: While a statistically significant decline was recorded in NLR and PLR (p<0.05), no significant changewas observed in MPV and CRP after the therapy success where patients achieved an improvement greater thanor equal to PASI 75.Conclusion: We conclude that the correlation with the response to treatment and NLR and PLR levels showthat these markers may be beneficial for assessment of disease severity either in combination with currentscores or alone. These markers are cost effective predictors that can easily be measured in routine practice.
Anahtar Kelime: Orta şiddette ve şiddetli psoriasis hastalarında ustekinumab tedavisi sonrası inflamatuar belirteçlerde azalma
Öz: Giriş: Psoriasis kronik, inflamatuar ve sistemik bir hastalıktır.Psoriasiste hastalık şiddetini ölçmek için Psoriasis Alan Şiddet İndeksi (PAŞİ) yanı sıra daha objektif laboratuar araçlarına ihtiyaç vardır. Nötrofil lenfosit oranı (NLO), trombosit lenfosit oranı (TLO) ve ortalama trombosit hacmi (OTH) çeşitli inflamatuar hastalıklarda arttığı bilinen belirteçlerdir. Bu çalışmada amacımız orta şiddette ve şiddetli psoriasis vulgarisi olan hastalarda NLO, TLO ve OTH değerlerinin ustekinumab tedavisi ile değişimlerini araştırmaktır. Gereç ve yöntem: Çalışmada orta şiddette veya şiddetli psoriasis vulgarisi olup, ustekinumab tedavisi verilen kronik plak tipi psoriasis tanılı 25 hasta retrospektif olarak değerlendirilmiştir. Hastaların tedavi öncesi PAŞİ, tam kan sayımı parametreleri, serum CRP seviyeleri ve PAŞİ 75 ve/veya üzeri başarı elde edildikleri kontrollerindeki değerleri kaydedilmiştir. Tam kan sayımı belirteçleri, OTH ve CRP değeri determine edilmiştir. Ek inflamatuar hastalığı ve eşlik eden enfeksiyonu olanlar çalışma dışı bırakılmıştır. Bulgular: Hastaların PAŞİ 75 başarı ve üzeri elde ettikleri incelemelerde NLO, TLO oranlarında istatistiksel olarak anlamlı düşme (p<0,05) saptanırken OTH ve CRP değerlerinde tedavi başarısı sonrası anlamlı değişiklik izlenmemiştir. Sonuç: NLO ve TLO değerlerinde tedavi yanıtı alınmasıyla anlamlı düşme olduğu gösterdik. Bu göstergeler rutin pratikte kolay ölçülebilen ve maliyet açısından verimli belirteçlerdir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Taskin B, MEMET B, Vurgun E, ALPER F (2021). Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis. , 452 - 459. 10.31362/patd.748871 |
| Chicago | Taskin Banu,MEMET BACHAR,Vurgun Eren,ALPER FATMA SİBEL Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis. (2021): 452 - 459. 10.31362/patd.748871 |
| MLA | Taskin Banu,MEMET BACHAR,Vurgun Eren,ALPER FATMA SİBEL Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis. , 2021, ss.452 - 459. 10.31362/patd.748871 |
| AMA | Taskin B,MEMET B,Vurgun E,ALPER F Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis. . 2021; 452 - 459. 10.31362/patd.748871 |
| Vancouver | Taskin B,MEMET B,Vurgun E,ALPER F Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis. . 2021; 452 - 459. 10.31362/patd.748871 |
| IEEE | Taskin B,MEMET B,Vurgun E,ALPER F "Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis." , ss.452 - 459, 2021. 10.31362/patd.748871 |
| ISNAD | Taskin, Banu vd. "Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis". (2021), 452-459. https://doi.org/10.31362/patd.748871 |
| APA | Taskin B, MEMET B, Vurgun E, ALPER F (2021). Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis. Pamukkale Tıp Dergisi, 14(2), 452 - 459. 10.31362/patd.748871 |
| Chicago | Taskin Banu,MEMET BACHAR,Vurgun Eren,ALPER FATMA SİBEL Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis. Pamukkale Tıp Dergisi 14, no.2 (2021): 452 - 459. 10.31362/patd.748871 |
| MLA | Taskin Banu,MEMET BACHAR,Vurgun Eren,ALPER FATMA SİBEL Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis. Pamukkale Tıp Dergisi, vol.14, no.2, 2021, ss.452 - 459. 10.31362/patd.748871 |
| AMA | Taskin B,MEMET B,Vurgun E,ALPER F Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis. Pamukkale Tıp Dergisi. 2021; 14(2): 452 - 459. 10.31362/patd.748871 |
| Vancouver | Taskin B,MEMET B,Vurgun E,ALPER F Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis. Pamukkale Tıp Dergisi. 2021; 14(2): 452 - 459. 10.31362/patd.748871 |
| IEEE | Taskin B,MEMET B,Vurgun E,ALPER F "Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis." Pamukkale Tıp Dergisi, 14, ss.452 - 459, 2021. 10.31362/patd.748871 |
| ISNAD | Taskin, Banu vd. "Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis". Pamukkale Tıp Dergisi 14/2 (2021), 452-459. https://doi.org/10.31362/patd.748871 |
