Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation

Yıl: 2020 Cilt: 62 Sayı: 4 Sayfa Aralığı: 266 - 271 Metin Dili: İngilizce DOI: 10.4274/gulhane.galenos.2020.1180 İndeks Tarihi: 16-06-2021

Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation

Öz:
Aims: Medulloblastoma is very rare and accounts for only 1% of intracranial tumors in adults. There are limited treatment options for adult medulloblastoma patients who have relapsed or refractory disease. We aimed to show real-life data on health outcomes in adult patients with recurrent or refractory medulloblastoma patients who received autologous hematopoietic stem cell transplantation (AHSCT).Methods: We analyzed the data of 15 patients who underwent AHSCT after ifosfamide, carboplatin, and etoposide (ICE) as high-dose chemotherapy (HDCT) regimen for relapsed or refractory medulloblastoma from 2010 to 2020. Overall response rate (ORR), overall survival (OS) and progression-free survival (PFS) of the patients were evaluated.Results: Fifteen patients were observed in this study. The mean age of the study group was 27.9±8.1 years and 53.3% of the patients were female (n=8). ORR was 100%. The median OS and PFS were 24 months [95% confidence interval (CI): 11.4-36.5] and 13 months (95% CI: 10.2-15.8), respectively. One-year OS and PFS rates were 77% and 55.2%, respectively. Five-year OS rate was 82.5%.Conclusions: AHSCT with ICE as HDCT regimen is a safe and effective treatment option for relapsed or refractory adult medulloblastoma patients with an acceptable ORR, OS and PFS time.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Farwell JR, Dohrmann GJ, Flannery JT. Medulloblastoma in childhood: an epidemiological study. J Neurosurg. 1984;61:657-664.
  • 2. Merchant TE, Pollack IF, Loeffler JS. Brain tumors across the age spectrum: biology, therapy, and late effects. Semin Radiat Oncol. 2010;20:58-66.
  • 3. Bolek TW, McCollough WM, Maria BL,et al. Medulloblastoma: time–dose relationship based on a 30- year review. Int J Radiat Oncol Biol Phys. 1998;42:147- 154.
  • 4. Gottardo NG, Gajjar A. Current therapy for medulloblastoma. Curr Treat Options Neurol. 2006;8:319-334.
  • 5. Majd N, Penas-Prado M. Updates on management of adult medulloblastoma. Curr Treat Options Oncol. 2019;20:64.
  • 6. Zia M, Forsyth P, Chaudhry A, Russell J, Stewart D. Possible benefits of high-dose chemotherapy and autologous stem cell transplantation for adults with recurrent medulloblastoma. Bone Marrow Transplant. 2002;30:565-569.
  • 7. Dunkel IJ, Gardner SL, Garvin JH, Goldman S, Shi W, Finlay JL. High-dose carboplatin, thiotepa, and etoposide with autologous stem cell rescue for patients with previously irradiated recurrent medulloblastoma. Neuro-oncology. 2010;12:297-303.
  • 8. Okada S, Hongo T, Sakaguchi K, Suzuki K, Nishizawa S, Ohzeki T. Pilot study of ifosfamide/carboplatin/etoposide (ICE) for peripheral blood stem cell mobilization in patients with high-risk or relapsed medulloblastoma. Childs Nerv Syst. 2007;23:407-413.
  • 9. Bouffet E. Management of high-risk medulloblastoma. Neurochirurgie. 2019;20;S0028-S3770:30178-X.
  • 10. Brandes A, Franceschi E, Tosoni A, et al. Efficacy of tailored treatment for high-and low-risk medulloblastoma in adults: A large prospective phase II trial. Journal of Clinical Oncology. 2010;28:(Suppl 15):2003.
  • 11. Beier D, Proescholdt M, Reinert C, et al. Multicenter pilot study of radiochemotherapy as first-line treatment for adults with medulloblastoma (NOA-07). Neuro-Oncol. 2018;20:400-410.
  • 12. Packer RJ, Goldwein J, Nicholson HS, Vezina LG, et al. Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children’s Cancer Group Study. J Clin Oncol. 1999;17:2127-2136.
  • 13. Kessinger A. High dose chemotherapy with autologous bone marrow rescue for high grade gliomas of the brain: a potential for improvement in therapeutic results. Neurosurgery. 1984;15:747-750.
  • 14. Brandes AA, Bartolotti M, Marucci G, et al. New perspectives in the treatment of adult medulloblastoma in the era of molecular oncology. Crit Rev Oncol Hematol. 2015;94:348- 359.
  • 15. Kool M, Korshunov A, Remke M, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 2012;123:473-484.
  • 16. Remke M, Hielscher T, Northcott PA, et al. Adult medulloblastoma comprises three major molecular variants. J Clin Oncol. 2011;29:2717-2723.
APA Acar R, erturk i, Okcelik S, Kiziloz H, yildiz b, aykan m, Keskin G, Sertoğlu B, BAŞGÖZ B, Karadurmuş N (2020). Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation. , 266 - 271. 10.4274/gulhane.galenos.2020.1180
Chicago Acar Ramazan,erturk ismail,Okcelik Sezgin,Kiziloz Halil,yildiz birol,aykan musa baris,Keskin Gul Sema,Sertoğlu Berken,BAŞGÖZ Bilgin Bahadır,Karadurmuş Nuri Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation. (2020): 266 - 271. 10.4274/gulhane.galenos.2020.1180
MLA Acar Ramazan,erturk ismail,Okcelik Sezgin,Kiziloz Halil,yildiz birol,aykan musa baris,Keskin Gul Sema,Sertoğlu Berken,BAŞGÖZ Bilgin Bahadır,Karadurmuş Nuri Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation. , 2020, ss.266 - 271. 10.4274/gulhane.galenos.2020.1180
AMA Acar R,erturk i,Okcelik S,Kiziloz H,yildiz b,aykan m,Keskin G,Sertoğlu B,BAŞGÖZ B,Karadurmuş N Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation. . 2020; 266 - 271. 10.4274/gulhane.galenos.2020.1180
Vancouver Acar R,erturk i,Okcelik S,Kiziloz H,yildiz b,aykan m,Keskin G,Sertoğlu B,BAŞGÖZ B,Karadurmuş N Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation. . 2020; 266 - 271. 10.4274/gulhane.galenos.2020.1180
IEEE Acar R,erturk i,Okcelik S,Kiziloz H,yildiz b,aykan m,Keskin G,Sertoğlu B,BAŞGÖZ B,Karadurmuş N "Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation." , ss.266 - 271, 2020. 10.4274/gulhane.galenos.2020.1180
ISNAD Acar, Ramazan vd. "Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation". (2020), 266-271. https://doi.org/10.4274/gulhane.galenos.2020.1180
APA Acar R, erturk i, Okcelik S, Kiziloz H, yildiz b, aykan m, Keskin G, Sertoğlu B, BAŞGÖZ B, Karadurmuş N (2020). Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation. Gülhane Tıp Dergisi, 62(4), 266 - 271. 10.4274/gulhane.galenos.2020.1180
Chicago Acar Ramazan,erturk ismail,Okcelik Sezgin,Kiziloz Halil,yildiz birol,aykan musa baris,Keskin Gul Sema,Sertoğlu Berken,BAŞGÖZ Bilgin Bahadır,Karadurmuş Nuri Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation. Gülhane Tıp Dergisi 62, no.4 (2020): 266 - 271. 10.4274/gulhane.galenos.2020.1180
MLA Acar Ramazan,erturk ismail,Okcelik Sezgin,Kiziloz Halil,yildiz birol,aykan musa baris,Keskin Gul Sema,Sertoğlu Berken,BAŞGÖZ Bilgin Bahadır,Karadurmuş Nuri Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation. Gülhane Tıp Dergisi, vol.62, no.4, 2020, ss.266 - 271. 10.4274/gulhane.galenos.2020.1180
AMA Acar R,erturk i,Okcelik S,Kiziloz H,yildiz b,aykan m,Keskin G,Sertoğlu B,BAŞGÖZ B,Karadurmuş N Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation. Gülhane Tıp Dergisi. 2020; 62(4): 266 - 271. 10.4274/gulhane.galenos.2020.1180
Vancouver Acar R,erturk i,Okcelik S,Kiziloz H,yildiz b,aykan m,Keskin G,Sertoğlu B,BAŞGÖZ B,Karadurmuş N Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation. Gülhane Tıp Dergisi. 2020; 62(4): 266 - 271. 10.4274/gulhane.galenos.2020.1180
IEEE Acar R,erturk i,Okcelik S,Kiziloz H,yildiz b,aykan m,Keskin G,Sertoğlu B,BAŞGÖZ B,Karadurmuş N "Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation." Gülhane Tıp Dergisi, 62, ss.266 - 271, 2020. 10.4274/gulhane.galenos.2020.1180
ISNAD Acar, Ramazan vd. "Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation". Gülhane Tıp Dergisi 62/4 (2020), 266-271. https://doi.org/10.4274/gulhane.galenos.2020.1180