Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme

Aygül Tunç Aksan (Milli Eğitim Bakanlığı, Mersin, Türkiye)
Psikiyatride Güncel Yaklaşımlar
9 2
Yıl: 2021 Cilt: 13 Sayı: 1 Sayfa Aralığı: 34 - 51 Metin Dili: Türkçe DOI: 10.18863/pgy.718479 İndeks Tarihi: 17-06-2021

Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme

Öz:
Bilişsel Davranışçı Terapi (BDT) biyolojik, psikolojik ve sosyal sıkıntı yaşayan meme kanserli kadınlar (MKK) için etkili birpsikoterapötik yaklaşım olduğu sistematik derleme ve meta-analiz çalışmalarıyla kanıtlanmıştır. Bununla birlikte BDT farklıkuşaklardan oluşmaktadır. Son yıllarda Kabul ve Kararlılık Terapisi (KKT) ve Bilinçli Farkındalık Temelli Bilişsel Terapi (BFTBT) gibiüçüncü kuşak yaklaşımlar meme kanserinde psikolojik müdahaleler olarak kullanılmaya başlandığı görülmektedir. Bu çalışmadaikinci ve üçüncü kuşak BDT’ye dayalı randomize kontrollü çalışmaların MKK’nin biyo-psiko-sosyal sıkıntıları üzerindeki etkilerisistematik olarak taranarak değerlendirilmesi amaçlanmıştır. Alan yazın taraması Google Akademik, PubMed ve Ulakbim olmaküzere 3 elektronik veri tabanında ve İngilizce ve Türkçe terimlerle yürütülmüştür. Taramaya meme kanserli kadınlarla, ikinci yada üçüncü kuşak BDT’lerle yürütülmüş ve araştırma desenleri randomize kontrollü olan çalışmalar dahil edilmiştir. Çalışmayadahil edilme kriterlerine uyan 21 çalışmaya ulaşılmıştır. Bu çalışmalardan 16’sı BDT, 3 tanesi KKT ve 2 tanesi de BFTBT temelindeuygulanan çalışmalar olarak kategorize edilmişlerdir. BDT’lerin, depresyon, uykusuzluk, bilişsel bozulma, menopoz belirtileri,yorgunluk, fizyolojik uyum, ağrı, yaşam kalitesi, psiko-sosyal uyum, öz-saygı ve cinsel işlev bozukluğunda etkili olduğu gözlenmiştir.
Anahtar Kelime:

Effectiveness of Cognitive Behavioral Therapies in Women with Breast Cancer: A Systematic Review

Öz:
Cognitive Behavioral Therapy (CBT) has been proven by systematic review and meta-analysis studies that it is an effective psychotherapeutic approach for women with breast cancer (WBC) having biological, psychological, and social distress. However, CBT consists of different waves. In recent years, it is found that third wave approaches such as Acceptance and Commitment Therapy (ACT) and Mindfulness Based Cognitive Therapy (MBCT) are used as psychological interventions in breast cancer. In the present study, the aim is to assess the effects of randomized controlled studies based on second and third wave Cognitive Behavioral Therapies on the bio-psycho-social distress of WBC by a systematic review. Literature review was conducted on 3 electronic databases, Google Academic, PubMed, and Ulakbim, by using English and Turkish keywords. Studies executed with second- or third-wave CBT in women with breast cancer and with randomized controlled research designs were included in the review. 21 studies complying with the eligibility criteria were found. Among these studies, 16 were categorized as the studies conducted based on CBT, 3 based on ACT, and 2 based on MBCT. CBT are effective in depression, insomnia, cognitive impairment, menopausal symptoms, fatigue related by cancer, physical adaptation, pain, life quality, psycho-social adaptation, self-esteem, and sexual dysfunction.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Andersen BL, Anderson B, de Prosse CD (1989) Controlled prospective longitudinal study of women with cancer: II. psychological outcomes. J Consult Clin Psychol, 37:692-697.
  • Antoni MH (2003) Stress Management Intervention for Women with Breast Cancer. Washington DC, American Psychological Press.
  • Antoni MH, Lechner S, Diaz A, Vargas S, Holley H, Phillips, K et al. (2009) Cognitive behavioral stress management effects on psychosocial and physiological adaptation in women undergoing treatment for breast cancer. Brain Behav. Immun, 23:580-591.
  • Aricò D, Raggi A, Ferri R (2016) Cognitive behavioral therapy for insomnia in breast cancer survivors: A review of the literature. Front Psychol, 7:1162.
  • Atema V, van Leeuwen M, Kieffer JM, Oldenburg HSA, van Beurden M, Gerritsma MA et al. (2019) Efficacy of ınternet-based cognitive behavioral therapy for treatment-ınduced menopausal symptoms in breast cancer survivors: Results of a randomized controlled trial. J Clin Oncol, 37:809-822.
  • Beatty, Kemp E, Butow P, Girgis A, Schofield P, Turner J et al. (2018) A systematic review of psychotherapeutic interventions for women with metastatic breast cancer: Context matters. Psychooncology. 27:34– 42.
  • Bell AC, D’Zurilla TJ (2009) Problem-solving therapy for depression: A meta-analysis. Clin Psychol Rev, 29:348–353.
  • Bennett KK, Compas BE, Beckjord E, Judith GG (2005) Self-blame and distress among women with newly diagnosed breast cancer. JJ Behav Med, 28:313-3323.
  • Bickman L, Reich S (2015) Randomized controlled trials. In Credible and Actionable Evidence: The Foundations for Rigorous and Influential Evaluations, 2nd ed. (Eds S Donaldson, C Christie, M Mark):83-113. Thousand Oaks, Sage.
  • Bishop SR, Lau M, Shapiro S, Carlson L, Anderson ND, Carmody J et al. (2004) Mindfulness: a proposed operational definition. Clin Psychol (New York), 1:230–241.
  • Blow AJ, Swieciciki P, Hann P, Osuch JR, Symonds LL, Smith SS et al. (2011) The emotional journey of women experiencing a breast abnormality. Qual Health Res, 21:1316-1334.
  • Burschka JM, Keune PM, Oy UH, Oschmann P, Kuhn P (2014) Mindfulness-based interventions in multiple sclerosis: Beneficial effects of Tai Chi on balance, coordination, fatigue and depression. BMC Neurol,14:165.
  • Cornacchio D, Sanchez A, Chou T, Comer J (2017) Cognitive-behavioral therapy for children and adolescents. In The Science of Cognitive Behavioral Therapy, 1st ed. (Eds SA Hofmann, JG Gordon):257-288. London, Academic Press.
  • Daniels S (2015) Cognitive behavior therapy for patients with cancer. J Adv Pract Oncol, 6:54-56.
  • David D, Cristea IA, Beck AT (2018) Varieties of psychotherapy for major depressive disorder in adults: An evidence-based evaluation. In Evidence-Based Psychotherapy: The State of the Science and Practice (Eds D David, SJ Lynn, G H Montgomery):11–36. Hoboken, NJ, Wiley-Blackwell.
  • de la Torre-Luque A, Gambara HE, López E, Cruzado, JA (2016) Psychological treatments to improve quality of life in cancer contexts: A meta-analysis. Int J Clin Health Psychol, 16:211-219.
  • Dimidjian S, Hollon S D, Dobson KS, Schmaling KB, Kohlenberg RJ, Addis ME (2006) Randomized trial of behavioral activation, cognitive therapy, and antidepressant medication in the acute treatment of adults with major depression. J Consult Clin Psychol, 74:658-670.
  • Donovan CL (2013) Using new technologies to deliver cognitive behaviour therapy with children and adolescents. In Cognitive
  • Behaviour Therapy for Children and Families 3rd ed. (Eds P Graham, S Reynolds):629-662. New York, Cambridge University Press.
  • Faller H, Schuler M, Richard M, Heckl U, Weis J, Küffner R (2013) Effects of psycho-oncologic interventions on emotional distress and quality of life in adult patients with cancer: Systematic review and meta-analysis. J Clin Oncol, 31:782-793.
  • Ferguson R, Sigmon S, Pritchard A, LaBrie S, Goetze R, Fink C, Garrett A (2016) A randomized trial of video conference‐delivered cognitive behavioral therapy for survivors of breast cancer with self‐reported cognitive dysfunction. Cancer, 122):1782-1791.
  • Ferlay J, Shin H, Bray FD, Mathers C, Parkin D (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127:2893-2917.
  • Gandubert C, Carrière I, Escot C, Soulier M, Hermès A, Boulet P et al. (2009) Onset and relapse of psychiatric disorders following early breast cancer: A case–control study. Psychooncology, 18:1029-1037.
  • Ganz PA (2008) Psychological and social aspects of breast cancer. Oncology (Williston Park), 22:642-646.
  • Gawrysiak M, Nicholas C, Hopko DR (2009) Behavioral activation for moderately depressed university students: Randomized controlled trial. J Couns Psychol, 56:468-475.
  • González-Fernández S, Fernández-Rodríguez C (2019) Acceptance and commitment therapy in cancer: Review of applications and findings. Behav Med, 45:255-269.
  • Guarino A, Polini C, Forte G, Favieri F, Boncompagni I, Casagrande M (2020) The effectiveness of psychological treatments in women with breast cancer: A systematic review and meta-analysis. J Clin Med, 9:209.
  • Gudenkauf LM, Antoni MH, Stagl JM, Lechner S, Jutagir DR et al. (2015) Brief cognitive-behavioral and relaxation training interventions for breast cancer: A randomized controlled trial. J Consult Clin Psychol, 83:677-688.
  • Gültekin M, Boztaş G (2014) Türkiye Kanser İstatistikleri. Ankara, TC Sağlık Bakanlığı.
  • Harcourt D, Rumsey N, Aambler N (1999) Same-day diagnosis of symptomatic breast problems: Psychological impact and coping strategies. Psychol Health Med, 4:57-71.
  • Hayes SC, Hofmann S (2017) The third wave of cognitive behavioral therapy and the rise of process‐based care. World Psychiatry, 16:245- 246.
  • Hewitt M, Herdman R, Holland J (2004) Meeting Psychosocial Needs Of Women With Breast Canser/National Cancer Policy Board. Washington, National Academies Press.
  • Hopko DR, Armento M, Robertson SR, Carvalho J, Colman L, Mullane C et al. (2011) Brief behavioral activation and problem-solving therapy for depressed breast cancer patients: randomized trial. Consult Clin Psychol, 79:834-849.
  • Hopko DR, Funderburk JS, Shorey RC, McIndoo CC, Ryba MM, File AA et al. (2013) Behavioral activation and problem-solving therapy for depressed breast cancer patients: Preliminary support for decreased suicidal ideation. Behav Modif. 37:747-767.
  • Hopwood P, Howell A, Maguire P (1991). Screening for psychiatric morbidity in patients with advanced breast cancer: Validation of two self-report questionnaires. Br J Cancer, 64:353-356.
  • Hulbert‐Williams N, Storey L, Wilson K (2015) Psychological interventions for patients with cancer: psychological flexibility and the potential utility of Acceptance and Commitment Therapy Eur J Cancer Care (Engl), 24:15-27.
  • Hummel SB, Van Lankveld J, Oldenburg H, Hahn D E, Kieffer JM, Gerritsma MA et al. (2017) Efficacy of internet-based cognitive behavioral therapy in improving sexual functioning of breast cancer survivors: Results of a randomized controlled trial. J Clin Oncol, 35:1328-1340.
  • Institute of Medicine (IOM) (2008) Cancer Care For The Whole Patients: Meeting Psychosocial Health Needs. Washington, The National Academies Press.
  • Irwin M, Olmstead R, Motivala S (2008) Improving sleep quality in older adults with moderate sleep complaints: A randomized controlled trial of Tai Chi Chih. Sleep, 31:1001-1008.
  • Irwin M, Olmstead R, Carrillo C, Sadeghi N, Nicassio P, Ganz P, Bower J (2017) Tai Chi Chih compared with cognitive behavioral therapy for the treatment of insomnia in survivors of breast cancer: A randomized, partially blinded, noninferiority trial. J Clin Oncol, 35:2656- 2665.
  • Javadi TS, Tajikzadeh F, Bayat H, Eshraghi N, Roshandel Z, Rahmani S (2018) Comparison of effectiveness of the mindfulness-based cognitive therapy and the metacognition treatment on anxiety, depression and stress among breast cancer patients. Int Clin Neurosci J, 5:62-66.
  • Johannsen M, O’Connor M, O’Toole MS, Jensen AB, Højris I, Zachariae R (2016) Efficacy of mindfulness-based cognitive therapy on late post-treatment pain in women treated for primary breast cancer: A randomized controlled trial. J Clin Oncol, 34:3390-3399.
  • Johnson JA, Rash JA, Campbell TS, Savard J, Gehrman PR, Perlis M et al. (2016) A systematic review and meta-analysis of randomized controlled trials of cognitive behavior therapy for insomnia (CBT-I) in cancer survivors. Sleep Med Rev, 27:20-28,
  • Kabat-Zinn J. (1994) Wherever You Go, There You Are: Mindfulness Meditation in Everyday Life. New York, Hyperion.
  • Landmark BT, Strandmark M, Wahl A (2002) Breast cancer and experiences of social support: In-depth ınterviews of 10 women with newly diagnosed breast cancer. Scand J Caring Sci, 16:216-223.
  • Liberati IA, Altman D, Tetzlaff J, Mulrow C, Gøtzsche P, Ioannidis JD (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. PLoS Med, 6:e1000100.
  • Matthews H, Grunfeld EA, Turner A (2016) The efficacy of interventions to improve psychosocial outcomes following surgical treatment for breast cancer: A systematic review and meta-analysis. Psychooncology, 26:593-607.
  • Montazer A, Salehzadeh M, Nasirian M (2018) Efficacy and effectiveness of ıntegrating forgiveness into acceptance and commitment therapy for breast cancer patients’ adjustment: A preliminary randomized trial. Mental Disorders Letters, 1:34-38.
  • Montgomery G, Kanga, M, David D, Hallquist MN, Green S, Bovbjerg, D et al. (2009) Fatigue during breast cancer radiotherapy: an initial randomized study of cognitive behavioral therapy plus hypnosis. Health Psychol, 28:317-22.
  • Moodley LC (2011) Existential reflections of South African women with breast cancer. (Master thesis). Johannesburg, University of the Witwatersrand.
  • Moorey S, Watson M (2015) Cognitive therapy, 3rd ed. In Psycho-oncology (Eds. JC Holland, WS Breitbart, PB Jacobsen, MJ Loscalzo, R
  • McCorkle, PN Butow): 458-470. New York, Oxford University Press.
  • Mosher C, Secinti E, Li R, Hirsh A, Bricker J, Miller K et al. (2018) Acceptance and commitment therapy for symptom interference in metastatic breast cancer patients: A pilot randomized trial. Support Care Cancer, 26:1993-2004.
  • Najvani BD, Neshatdoost HT, Abedi MR, Mokarian F (2015) The effect of acceptance and commitment therapy on depression and psychological flexibility in women with breast cancer. Zahedan J Res Med Sci, 17:e965.
  • Nápoles AM, Ortíz C, Santoyo-Olsson J, Stewart AL, Gregorich S, Lee HE et al. (2015) Nuevo Amanecer: Results of a randomized controlled trial of a community-based, peer-delivered stress management intervention to improve quality of life in Latinas with breast cancer. Am J Public Health, 105 (Suppl 3):e55-e63.
  • Ogden J (2010). Understanding Breast Cancer. West Sussex, Wiley.
  • Özdel K (2015) Dünden bugüne bilişsel davranışçı terapiler: Teori ve uygulama. J Psychiatry-Special Topics, 8(2):10-20.
  • Pilevarzadeh M, Amirshahi M, Afsargharehbagh R, Rafiemanesh H, Hashemi SM, Balouchi A (2019) Global prevalence of depression among breast cancer patients: A systematic review and meta-analysis. Breast Cancer Res Treat, 176:519-533.
  • Qiu J, Chen W, Gao X, Xu Y, Tong H, Yang M (2013) A randomized controlled trial of group cognitive behavioral therapy for Chinese breast cancer patients with major depression. J Psychosom Obstet Gynaecol, 34:60-67.
  • Ruggiero GM, Spada MM, Caselli G, Sassaroli S (2018) A historical and theoretical review of cognitive behavioral therapies: From structural self knowledge to functional processes. J Ration Emot Cogn Behav Ther, 36:378-403.
  • Savard J, Ivers H, Savard MH, Morin CM (2014) Is a video-based cognitive behavioral therapy for insomnia as efficacious as a professionally administered treatment in breast cancer? Results of a randomized controlled trial. Sleep, 37:1305-1310.
  • Savard J, Ivers H, Savard MH, Morin CM (2016) Long-term effects of two formats of cognitive behavioral therapy for insomnia comorbid with breast cancer. Sleep, 39:813-823.
  • Savard J, Simard S, Ivers H (2005) Randomized study on the efficacy of cognitive-behavioral therapy for insomnia secondary to breast cancer, part I: Sleep and psychological effects. J Clin Oncol, 23:6083-6096.
  • Shockney LV, Shapiro GR (2009) 100 Questions and Answers About Advanced and Metastatic Breast Cancer, 2nd ed. Sudbury, Jones and Bartlett.
  • Stagl JM, Antoni MH, Lechner SC, Bouchard LC, Blomberg BB, Carver, CS (2015a) Randomized controlled trial of cognitive behavioral stress management in breast cancer: A brief report of effects on 5-year depressive symptoms. Health Psychol, 34:176-180.
  • Stagl JM, Bouchard LC, Lechner SC, Blomberg BB, Gudenkauf LM, Antoni MH (2015b) Long-term psychological benefits of cognitivebehavioral stress management for women with breast cancer: 11-year follow-up of a randomized controlled trial. Cancer. 121:1873- 1881.
  • Stanley K (2007) Design of randomized controlled trials. Circulation, 115:1164-1169.
  • Stoddard JA, Afari N (2014) The Big Book of Act Metaphors: A Practitioner’s Guide To Experiential Exercises and Metaphors in Acceptance and Commitment Therapy. Oakland CA, New Harbinger Publications.
  • Sütçü G (2010) Tanı ameliyat süresi yakın zamanlı olan hastaların öfke, depresyon, stresle başa çıkma ve sosyal destek değişkenleri açısından incelenmesi (Masters Thesis). Ankara, Ankara Üniversitesi.
  • Tatrow K, Montgomery G (2006) Cognitive behavioral therapy techniques for distress and pain in breast cancer patients: A metaanalysis. J Behav Med, 1:17-27.
  • Tunç-Aksan A, Gizir C (2017) Sağlık psikolojik danışmanlığı çerçevesinde meme kanserli kadınların yaşantıları ve psiko-sosyal gereksinimleri. Mersin University Journal of the Faculty of Education, 13:977-999.
  • Turner J, Kelly B, Swansonc C, Allison R, Wetzig N (2005) Psychosocial impact of newly diagnosed advanced breast cancer. Psychooncology, 14:396-407.
  • Vatan S (2016). Bilişsel davranışçı terapilerde üçüncü kuşak yaklaşımlar. Psikiyatride Güncel Yasklaşımlar, 8:190-203.
  • Wang YY. Wang F, Zheng W, Zhang L, Ng CH, Ungvari G et al. (2018) Mindfulness-based interventions for insomnia: A meta-analysis of randomized controlled trials. Behav Sleep Med, 18:1-9.
  • Ye M, Du K, Zhou J, Zhou Q, Shou M, Hu B et al. (2018) A meta-analysis of the efficacy of cognitive behavior therapy on quality of life and psychological health of breast cancer survivors and patients. Psychooncology, 27:1695-1703.
  • Yeager KR, Burgess AW, Roberts AR (2005) Crisis ıntervention for persons diagnosed with clinical disorders based on the stress-crisis continuum. In Crisis Intervention Handbook: Assessment, Treatment and Research, 3rd ed. (Eds AR Roberts): 128-150. Oxford ; New York, Oxford University Press
  • Yeo W, Kwan W, Teo P, Nip S, Wong E, Hin LY et al. (2004) Psychosocial impact of breast cancer surgeries in Chinese patients and their spouses. Psychooncology, 13:132-139.
  • Zachariae R, Amidi A, Damholdt M, Clausen C, Dahlgaard J, Lord H, et al. (2018) Internet-delivered cognitive-behavioral therapy for insomnia: A randomized controlled trial. J Natl Cancer Inst, 110:880-887.
  • Zhang M, Huang L, Feng Z, Shao L, Chen L (2017) Effects of cognitive behavioral therapy on quality of life and stress for breast cancer survivors: A meta-analysis. Minerva Med, 108:84-93.
APA Tunç Aksan A (2021). Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme. , 34 - 51. 10.18863/pgy.718479
Chicago Tunç Aksan Aygül Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme. (2021): 34 - 51. 10.18863/pgy.718479
MLA Tunç Aksan Aygül Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme. , 2021, ss.34 - 51. 10.18863/pgy.718479
AMA Tunç Aksan A Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme. . 2021; 34 - 51. 10.18863/pgy.718479
Vancouver Tunç Aksan A Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme. . 2021; 34 - 51. 10.18863/pgy.718479
IEEE Tunç Aksan A "Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme." , ss.34 - 51, 2021. 10.18863/pgy.718479
ISNAD Tunç Aksan, Aygül. "Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme". (2021), 34-51. https://doi.org/10.18863/pgy.718479
APA Tunç Aksan A (2021). Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme. Psikiyatride Güncel Yaklaşımlar, 13(1), 34 - 51. 10.18863/pgy.718479
Chicago Tunç Aksan Aygül Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme. Psikiyatride Güncel Yaklaşımlar 13, no.1 (2021): 34 - 51. 10.18863/pgy.718479
MLA Tunç Aksan Aygül Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme. Psikiyatride Güncel Yaklaşımlar, vol.13, no.1, 2021, ss.34 - 51. 10.18863/pgy.718479
AMA Tunç Aksan A Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme. Psikiyatride Güncel Yaklaşımlar. 2021; 13(1): 34 - 51. 10.18863/pgy.718479
Vancouver Tunç Aksan A Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme. Psikiyatride Güncel Yaklaşımlar. 2021; 13(1): 34 - 51. 10.18863/pgy.718479
IEEE Tunç Aksan A "Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme." Psikiyatride Güncel Yaklaşımlar, 13, ss.34 - 51, 2021. 10.18863/pgy.718479
ISNAD Tunç Aksan, Aygül. "Meme Kanserli Kadınlarda Bilişsel Davranışçı Terapilerin Etkililiği: Sistematik Derleme". Psikiyatride Güncel Yaklaşımlar 13/1 (2021), 34-51. https://doi.org/10.18863/pgy.718479
Sayfa Oluşturulma Tarihi
04-04-2024 7:18

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