Objective: Although many risk factors that cause postmastectomy pain syndrome (PMPS)have been searched, in literature, no study was found on the pathological type and thepresence of additional diseases. Its aimed to evaluate the frequency of PMPS and probabilityof being a risk factor of pathological type and the presence of additional diseases in whomunderwent mastectomy for breast cancer.Methods: The data of 392 patients who underwent mastectomy for breast cancer betweenthe years 2008 and 2016 were analyzed retrospectively. Demographic data, surgery type,radiotherapy, chemotherapy, presence of additional diseases, the pathologic diagnosis of thetumor, axillary dissection, number of total and metastatic lymph nodes, application status ofthe patients to Algology Clinic, VAS, Gabapentin, and/or Pregabalin usage were investigated.Gabapentin and/or Pregabalin usage was accepted as the presence of PMPS.Results: In our study, PMPS incidence was 24.4%. Statistically significant difference wasdetected between older age (>50; 72.6%) and hypertension (33.3%) with PMPS. The typeof surgery, axillary dissection, number of total and metastatic lymph nodes, radiotherapy,chemotherapy, and the pathological diagnosis of tumor were not determined as risk factors.Conclusion: Our determination of hypertension as a risk factor for PMPS with advancedage suggests that there is a need for prospective studies that address advanced age andhypertension. In addition, due to the retrospective study feature, an equal number of subgroupscould not be made for all pathological types. Therefore, we think that this relationshipcan be revealed more clearly with prospective studies in which every pathologicaldiagnosis is grouped equally.