IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice

Xu, Cunshuan; Zhang, Chunyan; Wang, Ze; li, deming

doi:10.3906/biy-2010-51

IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice

Deming LI, (Henan Normal University, State Key Laboratory Cell Differentiation and Regulation, Henan, China)

Ze WANG, (Henan Normal University, State Key Laboratory Cell Differentiation and Regulation, Henan, China)

Chunyan ZHANG, (Henan Normal University, State Key Laboratory Cell Differentiation and Regulation, Henan, China)

Cunshuan XU (Henan Normal University, State Key Laboratory Cell Differentiation and Regulation, Henan, China)

Turkish Journal of Biology

1 0

Yıl: 2021 Cilt: 45 Sayı: 2 Sayfa Aralığı: 225 - 234 Metin Dili: İngilizce DOI: 10.3906/biy-2010-51 İndeks Tarihi: 29-07-2022

IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice

Öz:

Inflammation has a dual effect: it can protect the body and destroy tissue and cell as well. The purpose of this experiment wasto determine the role of IL-1R1 in liver regeneration (LR) after partial hepatectomy (PH) in aged mice. The wild-type (WT, n = 36) andthe IL-1R1 knockout (KO, n = 36) 24-month-old C57BL/6J mice underwent two-thirds PH; 33 WT mice underwent sham operation.Liver coefficient was calculated by liver/body weight. The mRNA and protein expressions of genes were evaluated by quantitative realtime polymerase chain reaction (qRT-PCR) and Western blotting methods, respectively. Compared with WT mice, liver coefficient waslower in the IL-1R1 KO aged mice at 168 and 192 h (p = 0.039 and p = 0.027). The mRNA transcription of inflammation-related genesand cell cycle-associated genes decreased or delayed. The protein expressions of proliferation-related marker PCNA and proliferationassociated signaling pathway components JNK1, NF-κB and STAT3 reduced or retarded. There was stronger activation of proapoptoticproteins caspase-3, caspase-8 and BAX in the IL-1R1 KO mice at different time points (p < 0.05 or p < 0.01). IL-1R1 KO reducedinflammation and caused impaired liver regeneration after 2/3 partial hepatectomy in aged mice. Maintaining proper inflammation maycontribute to regeneration after liver partly surgical resection in the elderly.

Anahtar Kelime: liver resection regeneration inflammation IL-1R1 Aged mice

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	li d, Wang Z, Zhang C, Xu C (2021). IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice. , 225 - 234. 10.3906/biy-2010-51
Chicago	li deming,Wang Ze,Zhang Chunyan,Xu Cunshuan IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice. (2021): 225 - 234. 10.3906/biy-2010-51
MLA	li deming,Wang Ze,Zhang Chunyan,Xu Cunshuan IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice. , 2021, ss.225 - 234. 10.3906/biy-2010-51
AMA	li d,Wang Z,Zhang C,Xu C IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice. . 2021; 225 - 234. 10.3906/biy-2010-51
Vancouver	li d,Wang Z,Zhang C,Xu C IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice. . 2021; 225 - 234. 10.3906/biy-2010-51
IEEE	li d,Wang Z,Zhang C,Xu C "IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice." , ss.225 - 234, 2021. 10.3906/biy-2010-51
ISNAD	li, deming vd. "IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice". (2021), 225-234. https://doi.org/10.3906/biy-2010-51

APA	li d, Wang Z, Zhang C, Xu C (2021). IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice. Turkish Journal of Biology, 45(2), 225 - 234. 10.3906/biy-2010-51
Chicago	li deming,Wang Ze,Zhang Chunyan,Xu Cunshuan IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice. Turkish Journal of Biology 45, no.2 (2021): 225 - 234. 10.3906/biy-2010-51
MLA	li deming,Wang Ze,Zhang Chunyan,Xu Cunshuan IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice. Turkish Journal of Biology, vol.45, no.2, 2021, ss.225 - 234. 10.3906/biy-2010-51
AMA	li d,Wang Z,Zhang C,Xu C IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice. Turkish Journal of Biology. 2021; 45(2): 225 - 234. 10.3906/biy-2010-51
Vancouver	li d,Wang Z,Zhang C,Xu C IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice. Turkish Journal of Biology. 2021; 45(2): 225 - 234. 10.3906/biy-2010-51
IEEE	li d,Wang Z,Zhang C,Xu C "IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice." Turkish Journal of Biology, 45, ss.225 - 234, 2021. 10.3906/biy-2010-51
ISNAD	li, deming vd. "IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice". Turkish Journal of Biology 45/2 (2021), 225-234. https://doi.org/10.3906/biy-2010-51