Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer
Yıl: 2021 Cilt: 45 Sayı: 2 Sayfa Aralığı: 127 - 137 Metin Dili: İngilizce DOI: 10.3906/biy-2010-39 İndeks Tarihi: 29-07-2022
Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer
Öz: : Tumor stroma interaction is known to take a crucial role in cancer growth and progression. In the present study, it was performed gene expression analysis of stroma samples with ovarian and breast cancer through an integrative analysis framework to identifycommon critical biomolecules at multiomics levels. Gene expression datasets were statistically analyzed to identify common differentially expressed genes (DEGs) by comparing tumor stroma and normal stroma samples. The integrative analyses of DEGs indicatedthat there were 59 common core genes, which might be feasible to be potential marks for cancer stroma targeted strategies. Reportermolecules (i.e. receptor, transcription factors and miRNAs) were determined through a statistical test employing the hypergeometricprobability density function. Afterward, the tumor microenvironment protein-protein interaction and the generic network were reconstructed by using identified reporter molecules and common core DEGs. Through a systems medicine approach, it was determined thathub biomolecules, AR, GATA2, miR-124, TOR1AIP1, ESR1, EGFR, STAT1, miR-192, GATA3, COL1A1, in tumor microenvironmentgeneric network. These molecules were also identified as prognostic signatures in breast and ovarian tumor samples via survival analysis. According to literature searching, GATA2 and TORYAIP1 might represent potential biomarkers and candidate drug targets for thestroma targeted cancer therapy applications
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ERCEYLAN Ö, Savaş A, GOV E (2021). Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer. , 127 - 137. 10.3906/biy-2010-39 |
| Chicago | ERCEYLAN ÖMER FARUK,Savaş Ayşe,GOV ESRA Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer. (2021): 127 - 137. 10.3906/biy-2010-39 |
| MLA | ERCEYLAN ÖMER FARUK,Savaş Ayşe,GOV ESRA Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer. , 2021, ss.127 - 137. 10.3906/biy-2010-39 |
| AMA | ERCEYLAN Ö,Savaş A,GOV E Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer. . 2021; 127 - 137. 10.3906/biy-2010-39 |
| Vancouver | ERCEYLAN Ö,Savaş A,GOV E Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer. . 2021; 127 - 137. 10.3906/biy-2010-39 |
| IEEE | ERCEYLAN Ö,Savaş A,GOV E "Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer." , ss.127 - 137, 2021. 10.3906/biy-2010-39 |
| ISNAD | ERCEYLAN, ÖMER FARUK vd. "Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer". (2021), 127-137. https://doi.org/10.3906/biy-2010-39 |
| APA | ERCEYLAN Ö, Savaş A, GOV E (2021). Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer. Turkish Journal of Biology, 45(2), 127 - 137. 10.3906/biy-2010-39 |
| Chicago | ERCEYLAN ÖMER FARUK,Savaş Ayşe,GOV ESRA Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer. Turkish Journal of Biology 45, no.2 (2021): 127 - 137. 10.3906/biy-2010-39 |
| MLA | ERCEYLAN ÖMER FARUK,Savaş Ayşe,GOV ESRA Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer. Turkish Journal of Biology, vol.45, no.2, 2021, ss.127 - 137. 10.3906/biy-2010-39 |
| AMA | ERCEYLAN Ö,Savaş A,GOV E Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer. Turkish Journal of Biology. 2021; 45(2): 127 - 137. 10.3906/biy-2010-39 |
| Vancouver | ERCEYLAN Ö,Savaş A,GOV E Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer. Turkish Journal of Biology. 2021; 45(2): 127 - 137. 10.3906/biy-2010-39 |
| IEEE | ERCEYLAN Ö,Savaş A,GOV E "Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer." Turkish Journal of Biology, 45, ss.127 - 137, 2021. 10.3906/biy-2010-39 |
| ISNAD | ERCEYLAN, ÖMER FARUK vd. "Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer". Turkish Journal of Biology 45/2 (2021), 127-137. https://doi.org/10.3906/biy-2010-39 |
