Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir
Yıl: 2021 Cilt: 6 Sayı: 3 Sayfa Aralığı: 368 - 371 Metin Dili: İngilizce DOI: 10.26453/otjhs.872290 İndeks Tarihi: 29-07-2022
Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir
Öz: Objective: Favipiravir is recommended for treatmentof COVID-19 by the Turkey National Treatment Guideline for COVID-19. It has been widely used for COVID19 infected patients in Turkey. Fluorescence of the nailswith certain topical and systemic drugs with Wood’s lampwas and reported in the English literature. This study isdesigned to determine the fluorescence effect of favipiravir in the nails of COVID-19 patients.Materials and Methods: Eighty five patients withCOVİD-19 infection who were treated with favipiravirand/or hydroxychloroquine and 50 healthy volunteers’nails were examined by Wood’s lamp. Fluorescence andtherapeutic interest were recorded. Data were compared.Results: Seventy one of the patients (83.5% ) had fluorescent nails under UV radiation in the patient group,where no fluorescence was observed in the healthy controlgroup.Conclusion: Fluorescence of the nails in the patientswith confirmed COVID-19 infection who were treatedwith favipiravir is a common finding.
Anahtar Kelime: COVİD-19’un Favipiravir ile Tedavisi Sonrası Tırnaklarda Floresan Yansıma
Öz: Amaç: Favipiravir, COVID-19 Türkiye Ulusal Tedavi Klavuzunda, COVİD-19 tedavisi için önerilmektedir. Türkiye’de COVID-19 ile enfekte hastalarda yaygın olarak kullanılmaktadır. Belli topikal ve sistemik ilaçlar ilaçlarla tırnaklarda Wood lambası ile floresan yansıma bildirilmiştir. Bu çalışma, COVID-19 hastalarının tırnaklarında favipiravirin floresan etkisini belirlemek için tasarlanmıştır. Materyal ve Metot: Favipiravir ve/veya hidroksiklorokin ile tedavi edilen COVİD-19 enfeksiyonlu 85 hasta ve 50 sağlıklı gönüllünün tırnakları Wood lambası ile incelendi. Floresan yansıma ve ilaç öyküleri kaydedildi. Veriler karşılaştırıldı. Bulgular: Hasta grubunda, 71 hastada (% 83,5) UV radyasyon altında tırnaklarda floresan yansıma mevcuttu. Sağlıklı kontrol grubunda floresans gözlenmedi. Sonuç: Favipiravir ile tedavi edilen COVİD-19 tespit edilmiş hastaların tırnaklarında floresan yansıma yaygın bir bulgudur
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Aslan KM, Cebeci F, Erdemir VA, Aksoy H, Akdeniz N, Gürel MS. Fluorescence of nails and hair on Wood's lamp examination in Covid pandemic; undefined effect of Favipiravir in humans. Dermatol Ther. 2021;6:e14740.
- 2. Ilchyshyn A, Vickers CF. Yellow nail syndrome associated with penicillamine therapy. Acta Derm Venereol. 1983;63(6):554-555.
- 3. Lehuédé G, Toussirot E, Despaux J, Michel F, Wendling D. Yellow nail syndrome associated with thiol compound therapy for rheumatoid arthritis. Two case reports. Joint Bone Spine. 2002;69(4):406-408.
- 4. Kierland RR, Sheard C. Fluorescence of nails from quinacrine hydrochloride. J Am Med Assoc. 1946;6(131):809-810.
- 5. Piraccini BM, Iorizzo M. Drug Reactions Affecting the Nail Unit: Diagnosis and Management. Dermatologic Clinics. 2007;25(2):215-221.
- 6. Hendricks AA. Yellow lunulae with fluorescence after tetracycline therapy. Arch Dermatol. 1980;116(4):438-440.
- 7. Fam AG, Paton TW. Nail pigmentation after parenteral gold therapy for rheumatoid arthritis: “gold nails”. Arthritis Rheum. 1984;27: 119-120.
- 8. Patel S, Tosti A. An overview of management of drug-induced hair and nail disorders. Clinical Practice. 2014;11:327-339.
- 9. Giménez García RM, Carrasco Molina S. DrugInduced Hyperpigmentation: Review and Case Series. J Am Board Fam Med. 2019;32(4):628- 638.
- 10. Asawanonda P, Taylor CR. Wood’s light in dermatology. Int J Dermatol. 1999;38(11):801-807.
- 11. Safa MM, Ahmed AH, Sherin FH, Amira HK. Experimental design approach for development of spectrofluorimetric method for determination of favipiravir; a potential therapeutic agent against COVID-19 virus: Application to spiked human plasma, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc. 2021;249:119241. doi: 10.1016/ j.saa.2020.119241
- 12.T.C. Sağlik Bakanlığı. COVID-19 Rehberi 2020. https://covid19.saglik.gov.tr/TR-66301/covid-19- rehberi.html. Erişim tarihi 03 Eylül 2020.
| APA | KARABAY O, Sevimli Dikicier B, YALDIZ M, Guclu E (2021). Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir. , 368 - 371. 10.26453/otjhs.872290 |
| Chicago | KARABAY OĞUZ,Sevimli Dikicier Bahar,YALDIZ Mahizer,Guclu Ertugrul Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir. (2021): 368 - 371. 10.26453/otjhs.872290 |
| MLA | KARABAY OĞUZ,Sevimli Dikicier Bahar,YALDIZ Mahizer,Guclu Ertugrul Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir. , 2021, ss.368 - 371. 10.26453/otjhs.872290 |
| AMA | KARABAY O,Sevimli Dikicier B,YALDIZ M,Guclu E Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir. . 2021; 368 - 371. 10.26453/otjhs.872290 |
| Vancouver | KARABAY O,Sevimli Dikicier B,YALDIZ M,Guclu E Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir. . 2021; 368 - 371. 10.26453/otjhs.872290 |
| IEEE | KARABAY O,Sevimli Dikicier B,YALDIZ M,Guclu E "Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir." , ss.368 - 371, 2021. 10.26453/otjhs.872290 |
| ISNAD | KARABAY, OĞUZ vd. "Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir". (2021), 368-371. https://doi.org/10.26453/otjhs.872290 |
| APA | KARABAY O, Sevimli Dikicier B, YALDIZ M, Guclu E (2021). Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir. Online Türk Sağlık Bilimleri Dergisi, 6(3), 368 - 371. 10.26453/otjhs.872290 |
| Chicago | KARABAY OĞUZ,Sevimli Dikicier Bahar,YALDIZ Mahizer,Guclu Ertugrul Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir. Online Türk Sağlık Bilimleri Dergisi 6, no.3 (2021): 368 - 371. 10.26453/otjhs.872290 |
| MLA | KARABAY OĞUZ,Sevimli Dikicier Bahar,YALDIZ Mahizer,Guclu Ertugrul Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir. Online Türk Sağlık Bilimleri Dergisi, vol.6, no.3, 2021, ss.368 - 371. 10.26453/otjhs.872290 |
| AMA | KARABAY O,Sevimli Dikicier B,YALDIZ M,Guclu E Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir. Online Türk Sağlık Bilimleri Dergisi. 2021; 6(3): 368 - 371. 10.26453/otjhs.872290 |
| Vancouver | KARABAY O,Sevimli Dikicier B,YALDIZ M,Guclu E Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir. Online Türk Sağlık Bilimleri Dergisi. 2021; 6(3): 368 - 371. 10.26453/otjhs.872290 |
| IEEE | KARABAY O,Sevimli Dikicier B,YALDIZ M,Guclu E "Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir." Online Türk Sağlık Bilimleri Dergisi, 6, ss.368 - 371, 2021. 10.26453/otjhs.872290 |
| ISNAD | KARABAY, OĞUZ vd. "Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir". Online Türk Sağlık Bilimleri Dergisi 6/3 (2021), 368-371. https://doi.org/10.26453/otjhs.872290 |
