Objective: To compare the biometric values measured by Dual Scheimpflug-based and partial coherence interferometry-based optic biometers and to evaluate the intraocular lens (IOL) power cal- culations performed by using different formulas including SRK-2, SRK-T, Holladay 1 and Hoffer Q. Material and Methods: Patients who applied to our clinic with visual impairment and diagnosed as senil cataract were recruited in the current study. After detailed ophthalmo- logic examination, biometric measurements including mean anterior chamber depth (ACD), axial length (AL) and keratometric parameters (K1, K2) were performed by using the Galilei G6 Dual Scheimpflug Analyzer and IOL Master 500. The IOL power (Sensar AAB00 hy- drophobic acrylic IOL AMO) calculations targeting emmetropia were performed by using SRK-2, SRK-T, Holladay 1 and Hoffer Q formu- las with the two devices. These parameters were compared with statis- tical analysis. Results: One hundred and six eyes of 94 patients with nuclear sclerosis were recruited. The mean age of patients (40 female, 54 male) was 67.44±8.99 years. The value of K1 was found to be sta- tistically higher in measurement performed by IOL Master 500 (p<0.001). The IOL power was calculated statistically higher with all formulas measured by IOL Master 500 (p<0.001). Conclusion: The mean ACD, AL and K2 values did not differ between the two devices. Average K and K1 parameter was measured higher when measured with IOL Master 500. The mean IOL power was calculated statistically significantly different between these two devices.