Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors

Baygül, Arzu; İNAN, Urdoğan Neşe; Efe İris, Nur; pilancı, kezban nur; SÖNMEZ, EMİNE; DEMİREL, Aslıhan; Demir, Gökhan

doi:10.18621/eurj.573407

Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors

Aslıhan Demirel, (Kadıköy Florence Nightingale Hastanesi, Bulaşıcı Hastalıklar ve Klinik Mikrobiyoloji Bölümü, İstanbul, Türkiye)

Kezban Nur Pilancı, (İstanbul Aydın Üniversitesi, Tıp Fakültesi, Tıbbi Onkoloji Anabilim Dalı, İstanbul, Türkiye)

Neşe İnan, (TOBB Ekonomi ve Teknoloji Üniversitesi Hastanesi, Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Nur Efe İris, (İstanbul Bilim Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Arzu Baygül, (Beykent Üniversitesi, Tıp Fakültesi, Biyoistatistik ve Tıp Bilişimi Anabilim Dalı, İstanbul, Türkiye)

Gökhan Demir, (Acıbadem Üniversitesi, Tıp Fakültesi, Tıbbi Onkoloji Anabilim Dalı, İstanbul, Türkiye)

Emine Sönmez (Beykent Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

The European Research Journal

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Yıl: 2021 Cilt: 7 Sayı: 1 Sayfa Aralığı: 38 - 43 Metin Dili: İngilizce DOI: 10.18621/eurj.573407 İndeks Tarihi: 29-07-2022

Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors

Öz:

Objectives: Chemotherapy induces an immunosuppressive state in patients with solid organ tumors. Cytomegalovirus (CMV) reactivation as a result of immunosuppression causes a severe clinical manifestation. However, in this group, CMV infections developing due to reactivation were not adequately discussed in the literature. The aims of this study were to determine the incidence of CMV reactivation after chemotherapy, to evaluate the contribution of chemotherapy to reactivation, to determine the incidence of asymptomatic and symptomatic infections and to investigate the results of the treatment.Methods: A total of 93 patients with solid tumors were included in the study. Weekly blood samples were collected from the patients for three weeks before and after chemotherapy. Quantitative analysis of DNA was detected using CMV PCR kit (GeneProof CMV PCR kit, Bruno, Czech Republic). Diagnosis and treatment of patients were retrospectively reviewed.Results: Of the patients, 65.6% were female and 34.4% were male. The mean age was 55 ± 12 years. The most common cancer types among the patients were breast cancer in 45.2%, lung cancer in 15.1%, and colon cancer in 12.9%. The mean leukocyte count of the patients was 7,647/mm3. CMV DNA was not detected in any patient. According to this result, none of the patients had CMV reactivation after chemotherapy. Conclusions: In this study including patients with solid organ tumors with mild to moderate level of immunosuppression CMV DNA was not detected in any patient. Based on this finding no standard prophylaxis was required for CMV in this group of patients.

Anahtar Kelime: Cytomegalovirus,solid organ tumor,chemotherapy

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	DEMİREL A, pilancı k, İNAN U, Efe İris N, Baygül A, Demir G, SÖNMEZ E (2021). Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors. , 38 - 43. 10.18621/eurj.573407
Chicago	DEMİREL Aslıhan,pilancı kezban nur,İNAN Urdoğan Neşe,Efe İris Nur,Baygül Arzu,Demir Gökhan,SÖNMEZ EMİNE Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors. (2021): 38 - 43. 10.18621/eurj.573407
MLA	DEMİREL Aslıhan,pilancı kezban nur,İNAN Urdoğan Neşe,Efe İris Nur,Baygül Arzu,Demir Gökhan,SÖNMEZ EMİNE Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors. , 2021, ss.38 - 43. 10.18621/eurj.573407
AMA	DEMİREL A,pilancı k,İNAN U,Efe İris N,Baygül A,Demir G,SÖNMEZ E Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors. . 2021; 38 - 43. 10.18621/eurj.573407
Vancouver	DEMİREL A,pilancı k,İNAN U,Efe İris N,Baygül A,Demir G,SÖNMEZ E Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors. . 2021; 38 - 43. 10.18621/eurj.573407
IEEE	DEMİREL A,pilancı k,İNAN U,Efe İris N,Baygül A,Demir G,SÖNMEZ E "Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors." , ss.38 - 43, 2021. 10.18621/eurj.573407
ISNAD	DEMİREL, Aslıhan vd. "Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors". (2021), 38-43. https://doi.org/10.18621/eurj.573407

APA	DEMİREL A, pilancı k, İNAN U, Efe İris N, Baygül A, Demir G, SÖNMEZ E (2021). Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors. The European Research Journal, 7(1), 38 - 43. 10.18621/eurj.573407
Chicago	DEMİREL Aslıhan,pilancı kezban nur,İNAN Urdoğan Neşe,Efe İris Nur,Baygül Arzu,Demir Gökhan,SÖNMEZ EMİNE Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors. The European Research Journal 7, no.1 (2021): 38 - 43. 10.18621/eurj.573407
MLA	DEMİREL Aslıhan,pilancı kezban nur,İNAN Urdoğan Neşe,Efe İris Nur,Baygül Arzu,Demir Gökhan,SÖNMEZ EMİNE Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors. The European Research Journal, vol.7, no.1, 2021, ss.38 - 43. 10.18621/eurj.573407
AMA	DEMİREL A,pilancı k,İNAN U,Efe İris N,Baygül A,Demir G,SÖNMEZ E Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors. The European Research Journal. 2021; 7(1): 38 - 43. 10.18621/eurj.573407
Vancouver	DEMİREL A,pilancı k,İNAN U,Efe İris N,Baygül A,Demir G,SÖNMEZ E Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors. The European Research Journal. 2021; 7(1): 38 - 43. 10.18621/eurj.573407
IEEE	DEMİREL A,pilancı k,İNAN U,Efe İris N,Baygül A,Demir G,SÖNMEZ E "Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors." The European Research Journal, 7, ss.38 - 43, 2021. 10.18621/eurj.573407
ISNAD	DEMİREL, Aslıhan vd. "Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors". The European Research Journal 7/1 (2021), 38-43. https://doi.org/10.18621/eurj.573407