Effect of amino acid infusion on perioperative thermoregulation in newborn surgery
Yıl: 2021 Cilt: 7 Sayı: 1 Sayfa Aralığı: 32 - 37 Metin Dili: İngilizce DOI: 10.18621/eurj.635120 İndeks Tarihi: 29-07-2022
Effect of amino acid infusion on perioperative thermoregulation in newborn surgery
Öz: Objectives: Decreased drug metabolism, coagulation disorders, wound infections, and cardiac arrhythmias are the most important and well-known results of intraoperative hypothermia. Perioperative amino acid infusion is known to prevent intraoperative hypothermia during general anesthesia in adults. In this study, we aimed to demonstrate the effect of perioperative amino acid infusion on the prevention of hypothermia during general anesthesia in newborn surgery. Methods: Twenty surgical newborns, aged 1-30 days, were enrolled in this prospective randomized controlled study. Newborns were assigned randomly into two groups: the amino acid/dextrose (AAD) group and the dextrose (D) group. The core temperatures of the newborns were measured from the distal esophagus in the first minute of the induction once and every fifteen minutes thereafter. The core body temperature changes in each group during the operation and the differences between the two groups were analyzed. Results: The surgical operations in each group were similar. The mean operating room temperatures of AAD and D groups were 25.4 ± 0.2°C and 25.3 ± 0.3°C, respectively. There were no significant differences in the general characteristics of the two groups. The mean core temperatures began to decrease after the induction of anesthesia in both groups and continued to decrease during the course of the surgery. There was no significant difference between the two groups. Conclusions: Hypothermia develops in all neonates when surgical time exceeds one hour, even in warmer ambient temperatures. Although it seems effective in adults, amino acid-induced thermoregulation does not seem effective in newborns during general anesthesia.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Sessler DI. Perioperative thermoregulation and heat balance. Lancet 2016;387:2655-64.
- 2. Insler SR, Sessler DI. Perioperative thermoregulation and temperature monitoring. Anesthesiology Clin 2006;24:823-37.
- 3. Sessler DI. Complications and treatment of mild hypothermia. Anesthesiology 2001;95:531-43.
- 4. Kurz A, Sessler DI, Lenhardt R. Perioperative normothermia to reduce the incidence of surgical-wounds infection and shorten hospital stay. N Engl J Med 1996;334;1209-15.
- 5. Tander B, Barış S, Karakaya D, Arıtürk E, Rızalar R, Bernay B. Risk factors influencing inadvertent hypothermia in infants and neonates during anesthesia. Pediatr Anesth 2005;15:574-9.
- 6. Sellden E, Lindahl SGE. Amino acid-induced thermogenesis reduces hypothermia during anaesthesia and shortens hospital stay. Anesth Analg 1999; 89:916-22.
- 7. Sellden E. Peri-operative amino acid administration and the metabolic response to surgery. Proc Nutr Soc 2002;61:337-43.
- 8. Kasai T, Nakajima Y, Matsukawa T, Ueno H, Sanaguchi M, Mizobe T. Effect of preoperative amino acid infusion on thermoregulatory response during spinal anaesthesia. Br J Anaesth 2003;90:58-61.
- 9. Yamaoka I. Modification of core body temperature by amino acid administration. Asia Pac J ClinNutr 2008;17:309-11.
- 10. Nakajima Y, Takamata A, Matsukawa T, Sessler DI, Kitamura Y, Ueno H, et al. Effect of amino acid infusion on central thermoregulatory control in humans. Anesthesiology 2004;100:634-39.
- 11. Yokoyama T, Yamaoka I, Hitosugi T, Sellden E. Amino acids during perioperative period. Open J Anesthesiol 2017;7:287-95.
- 12. Himms-Hagen J. Nonshivering thermogenesis. Brain Res Bull 1984;12:151-60.
- 13. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, et al. Identification and importance of brown adipose tissue in adult humans. N Eng J Med 2009;360:1509-17.
- 14. Gunn TR, Gluckman PD. Perinatal thermogenesis. Early Hum Dev 1995;42:169-83.
- 15. Sellden E, Branström R, Brundin T. Augmented thermic effect of amino acids under general anaesthesia occurs mainly in extra-splanchnic tissues. Clin Sci 1996;91:431-9.
- 16. Sellden E, Lindahl SGE. Amino acid-induced thermogenesis to prevent hypothermia during anesthesia is not associated with increased stress response. Anesth Analg 1998:87;637-40.
- 17. Ohlson K, Lindahl S, Cannon B, Nedergaard J. Thermogenesis inhibition in brown adipocytes is a specific property in volatile anesthetics. Anesthesiology 2003;98:437-48.
- 18. Plattner O, Semsroth M, Sessler DI, Papousek A, Klasen C, Wagner O. Lack of nonshivering thermogenesis in infants anaesthetized with fentanyl and propofol. Anesthesiology 1997;86:772-7.
- 19. Dicker A, Ohlson KBE, Johnson L, Cannon B, Lindahl SGE, Nedergaard J. Halothane selectively inhibits nonshivering thermogenesis. Anesthesiology 1995;82:491-501.
- 20. Sultan P, Habib AS, Carvalho B. Ambient operating room temperature: mother, baby or surgeon? Br J Anaesth 2017;119:839.
- 21. Schricker T, Meterissian S, Donatelli F, Carvalho G, Mazza L, Eberhart E, et al. Parenteral nutrition and protein sparing after surgery: do we need glucose? Metabolism 2007;56:1044-50.
- 22. Fujita Y, Tokunaga C, Yamaguchi S, Nakamura K, Horiguchi Y, Kaneko M, et al. Effect of intraoperative amino acids with or without glucose infusion on body temperature, insulin, and blood glucose levels in patients undergoing laparoscopic colectomy: A preliminary report. Acta Anaesthesiol Taiwan 2014;52:101-6.
| APA | OKUMUŞ M, Salman T (2021). Effect of amino acid infusion on perioperative thermoregulation in newborn surgery. , 32 - 37. 10.18621/eurj.635120 |
| Chicago | OKUMUŞ Mustafa,Salman Tansu Effect of amino acid infusion on perioperative thermoregulation in newborn surgery. (2021): 32 - 37. 10.18621/eurj.635120 |
| MLA | OKUMUŞ Mustafa,Salman Tansu Effect of amino acid infusion on perioperative thermoregulation in newborn surgery. , 2021, ss.32 - 37. 10.18621/eurj.635120 |
| AMA | OKUMUŞ M,Salman T Effect of amino acid infusion on perioperative thermoregulation in newborn surgery. . 2021; 32 - 37. 10.18621/eurj.635120 |
| Vancouver | OKUMUŞ M,Salman T Effect of amino acid infusion on perioperative thermoregulation in newborn surgery. . 2021; 32 - 37. 10.18621/eurj.635120 |
| IEEE | OKUMUŞ M,Salman T "Effect of amino acid infusion on perioperative thermoregulation in newborn surgery." , ss.32 - 37, 2021. 10.18621/eurj.635120 |
| ISNAD | OKUMUŞ, Mustafa - Salman, Tansu. "Effect of amino acid infusion on perioperative thermoregulation in newborn surgery". (2021), 32-37. https://doi.org/10.18621/eurj.635120 |
| APA | OKUMUŞ M, Salman T (2021). Effect of amino acid infusion on perioperative thermoregulation in newborn surgery. The European Research Journal, 7(1), 32 - 37. 10.18621/eurj.635120 |
| Chicago | OKUMUŞ Mustafa,Salman Tansu Effect of amino acid infusion on perioperative thermoregulation in newborn surgery. The European Research Journal 7, no.1 (2021): 32 - 37. 10.18621/eurj.635120 |
| MLA | OKUMUŞ Mustafa,Salman Tansu Effect of amino acid infusion on perioperative thermoregulation in newborn surgery. The European Research Journal, vol.7, no.1, 2021, ss.32 - 37. 10.18621/eurj.635120 |
| AMA | OKUMUŞ M,Salman T Effect of amino acid infusion on perioperative thermoregulation in newborn surgery. The European Research Journal. 2021; 7(1): 32 - 37. 10.18621/eurj.635120 |
| Vancouver | OKUMUŞ M,Salman T Effect of amino acid infusion on perioperative thermoregulation in newborn surgery. The European Research Journal. 2021; 7(1): 32 - 37. 10.18621/eurj.635120 |
| IEEE | OKUMUŞ M,Salman T "Effect of amino acid infusion on perioperative thermoregulation in newborn surgery." The European Research Journal, 7, ss.32 - 37, 2021. 10.18621/eurj.635120 |
| ISNAD | OKUMUŞ, Mustafa - Salman, Tansu. "Effect of amino acid infusion on perioperative thermoregulation in newborn surgery". The European Research Journal 7/1 (2021), 32-37. https://doi.org/10.18621/eurj.635120 |
