Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU

Yazici, Aybuke; Ozkaya Parlakay, Aslinur; Ünal, Sevim; Siyah Bilgin, Betul

doi:10.12956/tchd.678719

Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU

Betül SİYAH BİLGİN, (Ankara Şehir Hastanesi, Ankara, Türkiye)

Aybuke YAZICI, (Ankara Şehir Hastanesi, Ankara, Türkiye)

Aslınur ÖZKAYA PARLAKAY, (Ankara Şehir Hastanesi, Ankara, Türkiye)

Sevim ÜNAL (Ankara Şehir Hastanesi, Ankara, Türkiye)

Türkiye Çocuk Hastalıkları Dergisi

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Yıl: 2020 Cilt: 14 Sayı: 2 Sayfa Aralığı: 168 - 175 Metin Dili: İngilizce DOI: 10.12956/tchd.678719 İndeks Tarihi: 26-07-2021

Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU

Öz:

Objective: In recent years, detection of viruses by multiplex real time polymerase chain reaction allowed the isolationof causative viral agents.The primary objectives of this study were to determine the distribution of causative respiratory viruses in acute lowerrespiratory tract infections in the NICU and to compare the demographic and clinical characteristics of infants with RSVand non-RSV infections. The secondary aim was to determine risk factors requiring respiratory support.Material and Methods: This retrospective observational study was conducted between January 2016 and June 2019.The infants were divided into two groups as RSV and non-RSV, and compared. Risk factors for respiratory support bymeans of invasive/non-invasive ventilation were determined.Results: Two hundred forty-three infants were hospitalized with the diagnosis of viral lower respiratory tract infectionsand a total of 119 infants, in which a causative viral agent could be isolated, were included in the study. RSV was themost common detected virus (n=93, 78%). The demographic characteristics of infants in RSV and non-RSV groupswere similar, except postnatal age. Infants were hospitalized most frequently in between December and February. Inmultivariate analysis, apnea and RSV were found to be risk factors for respiratory support requirement.Conclusion: Since RSV-associated acute lower respiratory tract infections are the most common and require morerespiratory support in the neonatal period, risk factors should be identified and preventive measures should be developed.Preventive strategies, raising awareness of families, careful and meticulous attitudes especially during high season mightreduce the incidence and hospitalizations of the infants

Anahtar Kelime:

Yenidoğan Yoğun Bakım Ünitesinde PCR ile Kanıtlanmış RSV ve RSV dışı Virüslerin Neden Olduğu Akut Alt Solunum Yolu Enfeksiyonları

Öz:

Amaç: Son yıllarda virusların mutipleks gerçek zamanlı polimeraz zincir reaksiyonu ile belirlenmesi, enfeksiyonlara neden olan viral ajanların izole edilmesine imkan sağlamıştır. Bu çalışmanın birincil amacı yenidoğan yoğun bakım ünitesinde akut alt solunum yolu enfeksiyonuna neden olan solunum yolu viruslarının dağılımını belirlemek ve RSV ve RSV dışı enfeksiyonu olan bebeklerin demografik ve klinik özelliklerini karşılaştırmaktır. İkincil amacı ise solunum desteği gerektiren risk faktörlerinin belirlenmesidir. Gereç ve Yöntemler: Bu geriye dönük gözlemsel çalışma Ocak 2016 ile Haziran 2019 yılları arasında yapıldı. Bebekler RSV ve RSV dışı olmak üzere iki gruba ayrılarak karşılaştırıldı. Solunum desteği gerektiren hastalar (invaziv ve non-invaziv ventilasyon) için risk faktörleri belirlendi. Bulgular: Viral alt solunum yolu enfeksiyonu tanısı ile 243 bebek hastaneye yatırıldı ve bu bebeklerden viral etken saptanan 119’u çalışmaya dahil edildi. En sık saptanan virüs RSV’di (n=93, %78). RSV ve RSV dışı gruplardaki bebeklerin demografik özellikleri postnatal yaş dışında benzerdi. Bebekler en sık Aralık ve Şubat ayları arasında hastaneye yatırıldı. Solunum desteği gerektiren risk faktörlerini belirlemek için yapılan multivariate analizinde apne ve RSV risk faktörü olarak bulundu. Sonuç: Yenidoğan döneminde RSV ile ilişkili akut alt solunum yolu enfeksiyonları en sık görülen ve daha fazla solunum desteği gerektirdiğinden, risk faktörleri tanımlanmalı ve önleyici yöntemler geliştirilmelidir. Önleyici stratejiler, ailelerin farkındalıklarının artırılması, özellikle sezonda dikkatli ve titiz davranışlarla bebeklerde enfeksiyonların görülme sıklığı ve hastaneye yatışlar azalabilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Siyah Bilgin B, Yazici A, Ozkaya Parlakay A, Ünal S (2020). Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU. , 168 - 175. 10.12956/tchd.678719
Chicago	Siyah Bilgin Betul,Yazici Aybuke,Ozkaya Parlakay Aslinur,Ünal Sevim Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU. (2020): 168 - 175. 10.12956/tchd.678719
MLA	Siyah Bilgin Betul,Yazici Aybuke,Ozkaya Parlakay Aslinur,Ünal Sevim Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU. , 2020, ss.168 - 175. 10.12956/tchd.678719
AMA	Siyah Bilgin B,Yazici A,Ozkaya Parlakay A,Ünal S Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU. . 2020; 168 - 175. 10.12956/tchd.678719
Vancouver	Siyah Bilgin B,Yazici A,Ozkaya Parlakay A,Ünal S Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU. . 2020; 168 - 175. 10.12956/tchd.678719
IEEE	Siyah Bilgin B,Yazici A,Ozkaya Parlakay A,Ünal S "Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU." , ss.168 - 175, 2020. 10.12956/tchd.678719
ISNAD	Siyah Bilgin, Betul vd. "Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU". (2020), 168-175. https://doi.org/10.12956/tchd.678719

APA	Siyah Bilgin B, Yazici A, Ozkaya Parlakay A, Ünal S (2020). Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU. Türkiye Çocuk Hastalıkları Dergisi, 14(2), 168 - 175. 10.12956/tchd.678719
Chicago	Siyah Bilgin Betul,Yazici Aybuke,Ozkaya Parlakay Aslinur,Ünal Sevim Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU. Türkiye Çocuk Hastalıkları Dergisi 14, no.2 (2020): 168 - 175. 10.12956/tchd.678719
MLA	Siyah Bilgin Betul,Yazici Aybuke,Ozkaya Parlakay Aslinur,Ünal Sevim Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU. Türkiye Çocuk Hastalıkları Dergisi, vol.14, no.2, 2020, ss.168 - 175. 10.12956/tchd.678719
AMA	Siyah Bilgin B,Yazici A,Ozkaya Parlakay A,Ünal S Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU. Türkiye Çocuk Hastalıkları Dergisi. 2020; 14(2): 168 - 175. 10.12956/tchd.678719
Vancouver	Siyah Bilgin B,Yazici A,Ozkaya Parlakay A,Ünal S Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU. Türkiye Çocuk Hastalıkları Dergisi. 2020; 14(2): 168 - 175. 10.12956/tchd.678719
IEEE	Siyah Bilgin B,Yazici A,Ozkaya Parlakay A,Ünal S "Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU." Türkiye Çocuk Hastalıkları Dergisi, 14, ss.168 - 175, 2020. 10.12956/tchd.678719
ISNAD	Siyah Bilgin, Betul vd. "Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU". Türkiye Çocuk Hastalıkları Dergisi 14/2 (2020), 168-175. https://doi.org/10.12956/tchd.678719