Yıl: 2021 Cilt: 22 Sayı: 3 Sayfa Aralığı: 199 - 204 Metin Dili: İngilizce DOI: 10.5152/TurkThoracJ.2021.20255 İndeks Tarihi: 01-10-2021

Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia

Öz:
The COVID-19 pandemic is progressing rapidly, sending the world into a great panic. Healthcare professionals haveresponded by embarking on a concerted search for therapies to cure and prevent COVID-19. Recently, interferon (IFN) has emerged as apotential therapy as it is associated with reducing lung inflammation and suppressing viral replication. This research paper assessed theefficacy of high-dose nebulized IFN α 2b in severe COVID-19 pneumonia.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Guo YR, Cao QD, Hong ZS et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status. Mil Med Res. 2020;7(1):11. [CrossRef]
  • 2. Astuti I, Ysrafil. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response. Diabetes Metab Syndr. 2020;14(4):407-412. [CrossRef]
  • 3. Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrob Agents. 2020;55(3):105924. [CrossRef]
  • 4. Cascella M., Rajnik M, Cuomo A et al. Features, evaluation, and treatment of coronavirus. In: StatPearls. [Internet]. Treasure Island (FL): StatPearls Publishing; 2020
  • 5. Arıkan H, Karadoğan D, Tokgöz Akyıl F et al. COVID-19 treatment at a glance. Turk Thorac J. 2020;21(6):438-445. [CrossRef]
  • 6. Gao YM, Xu G, Wang B, Liu BC. Cytokine storm syndrome in coronavirus disease 2019: A narrative review [review]. J Intern Med. 2021;289(2):147-161. [CrossRef]
  • 7. Nile SH., Nile A., Qiu J et al. COVID-19: pathogenesis, cytokine storm and therapeutic potential of interferons. Cytokine Growth Factor Rev. 2020;53:66-70. [CrossRef]
  • 8. Davidson S, Maini MK, Wack A, Maini.MK. Disease-promoting effects of Type I interferons in viral, bacterial, and coinfections. J Interferon Cytokine Res. 2015;35(4):252-264. [CrossRef]
  • 9. Teijaro JR. Type I interferons in viral control and immune regulation. Curr Opin Virol. 2016;16:31-40. [CrossRef]
  • 10. Essaidi-Laziosi M, Geiser J, Huang S et al. Interferon-dependent and respiratory virus-specific interference in dual infections of airway epithelia. Sci Rep. 2020;10(1):10246. [CrossRef]
  • 11. Zhou Q, Chen V, Shannon CP et al. Interferon-α2b treatment for COVID-19. Front Immunol. 2020;11:1061. [CrossRef]
  • 12. Hussain S, Xie YJ, Li D et al. Current strategies against COVID19. Chin Med. 2020;15:70. [CrossRef]
  • 13. Charles PG, Wolfe R, Whitby M et al. SMART-COP: a tool for predicting the need for intensive respiratory or vasopressor support in community-acquired pneumonia. Clin Infect Dis. 2008;47(3):375-384. [CrossRef]
  • 14. Sheshadri A, Shah DP, Godoy M et al. Progression of the Radiologic Severity Index predicts mortality in patients with parainfluenza virus-associated lower respiratory infections. PLOS ONE. 2018;13(5):e0197418. [CrossRef]
  • 15. Geng Y, Wei Z, Qian H et al. Pathophysiological characteristics and therapeutic approaches for pulmonary injury and cardiovascular complications of coronavirus disease 2019. Cardiovasc Pathol. 2020;47:107228. [CrossRef]
  • 16. Dhochak N, Singhal T, Kabra SK, Lodha R. Pathophysiology of COVID-19: Why children fare better than adults? Indian J Pediatr. 2020;87(7):537-546. [CrossRef]
  • 17. Rehman S, Majeed T, Ansari MA et al. Current scenario of COVID-19 in pediatric age group and physiology of immune and thymus response. Saudi J Biol Sci. 2020;27(10):2567-2573. [CrossRef]
  • 18. Xu P, Huang J, Fan Z et al. Arbidol/IFN-α2b therapy for patients with coronavirus disease 2019: A retrospective multicenter cohort study. Microbes Infect. 2020;22(4-5):200-205. [CrossRef]
  • 19. Matera MG, Rogliani P, Calzetta L., Cazzola M. Pharmacological management of COVID-19 patients with ARDS (CARDS): A narrative review. Respir Med. 2020;171:106114. [CrossRef]
  • 20. Zimmermann P., Curtis N. Why is COVID-19 less severe in children ? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections. Arch Dis Child. 2020. [CrossRef]
APA Chkhis A, Abdulrazzaq N, Mokhtar S, aljasmi a (2021). Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia. , 199 - 204. 10.5152/TurkThoracJ.2021.20255
Chicago Chkhis Ayman,Abdulrazzaq Najiba,Mokhtar Sherif,aljasmi alia Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia. (2021): 199 - 204. 10.5152/TurkThoracJ.2021.20255
MLA Chkhis Ayman,Abdulrazzaq Najiba,Mokhtar Sherif,aljasmi alia Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia. , 2021, ss.199 - 204. 10.5152/TurkThoracJ.2021.20255
AMA Chkhis A,Abdulrazzaq N,Mokhtar S,aljasmi a Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia. . 2021; 199 - 204. 10.5152/TurkThoracJ.2021.20255
Vancouver Chkhis A,Abdulrazzaq N,Mokhtar S,aljasmi a Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia. . 2021; 199 - 204. 10.5152/TurkThoracJ.2021.20255
IEEE Chkhis A,Abdulrazzaq N,Mokhtar S,aljasmi a "Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia." , ss.199 - 204, 2021. 10.5152/TurkThoracJ.2021.20255
ISNAD Chkhis, Ayman vd. "Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia". (2021), 199-204. https://doi.org/10.5152/TurkThoracJ.2021.20255
APA Chkhis A, Abdulrazzaq N, Mokhtar S, aljasmi a (2021). Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia. Turkish Thoracic Journal, 22(3), 199 - 204. 10.5152/TurkThoracJ.2021.20255
Chicago Chkhis Ayman,Abdulrazzaq Najiba,Mokhtar Sherif,aljasmi alia Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia. Turkish Thoracic Journal 22, no.3 (2021): 199 - 204. 10.5152/TurkThoracJ.2021.20255
MLA Chkhis Ayman,Abdulrazzaq Najiba,Mokhtar Sherif,aljasmi alia Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia. Turkish Thoracic Journal, vol.22, no.3, 2021, ss.199 - 204. 10.5152/TurkThoracJ.2021.20255
AMA Chkhis A,Abdulrazzaq N,Mokhtar S,aljasmi a Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia. Turkish Thoracic Journal. 2021; 22(3): 199 - 204. 10.5152/TurkThoracJ.2021.20255
Vancouver Chkhis A,Abdulrazzaq N,Mokhtar S,aljasmi a Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia. Turkish Thoracic Journal. 2021; 22(3): 199 - 204. 10.5152/TurkThoracJ.2021.20255
IEEE Chkhis A,Abdulrazzaq N,Mokhtar S,aljasmi a "Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia." Turkish Thoracic Journal, 22, ss.199 - 204, 2021. 10.5152/TurkThoracJ.2021.20255
ISNAD Chkhis, Ayman vd. "Efficacy of High-Dose Nebulized Interferon α 2b in Severe COVID-19 Pneumonia". Turkish Thoracic Journal 22/3 (2021), 199-204. https://doi.org/10.5152/TurkThoracJ.2021.20255