Abdullah SAYINER
(Göğüs Hastalıkları Anabilim Dalı, Ege Üniversitesi, İzmir, Türkiye)
M. Sezai TAŞBAKAN
(Göğüs Hastalıkları Anabilim Dalı, Ege Üniversitesi, İzmir, Türkiye)
BEGÜM ERGAN
(Göğüs Hastalıkları Anabilim Dalı, Dokuz Eylül Üniversitesi, İzmir, Türkiye)
Oğuz KILINÇ
(Göğüs Hastalıkları Anabilim Dalı, Dokuz Eylül Üniversitesi, İzmir, Türkiye)
AYÇA ARZU SAYINER
(Tıbbi Mikrobiyoloji Anabilim Dalı, Dokuz Eylül Üniversitesi, İzmir, Türkiye)
Rüçhan SERTÖZ
(Tıbbi Mikrobiyoloji Anabilim Dalı, Ege Üniversitesi, İzmir, Türkiye)
Selin OZUYGUR
(Göğüs Hastalıkları Anabilim Dalı, Dokuz Eylül Üniversitesi, İzmir, Türkiye)
Selin ERCAN
(Göğüs Hastalıkları Anabilim Dalı, Dokuz Eylül Üniversitesi, İzmir, Türkiye)
Yusuf SAVRAN
(İç Hastalıkları Anabilim Dalı, Dokuz Eylül Üniversitesi, İzmir, Türkiye)
PERVİN KORKMAZ EKREN
(Göğüs Hastalıkları Anabilim Dalı, Ege Üniversitesi, İzmir, Türkiye)
Özen Kaçmaz BAŞOĞLU
(Göğüs Hastalıkları Anabilim Dalı, Ege Üniversitesi, İzmir, Türkiye)
Mustafa OZHAN
(Göğüs Hastalıkları Anabilim Dalı, Ege Üniversitesi, İzmir, Türkiye)
Yıl: 2021Cilt: 22Sayı: 3ISSN: 2149-2530Sayfa Aralığı: 247 - 250İngilizce

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Clinical Outcome of PCR-Negative COVID-19 Patients: A Retrospective Study
To evaluate the clinical features and outcomes of patients who were admitted with a diagnosis of coronavirus disease 2019(COVID-19) but who were not confirmed with polymerase chain reaction (PCR) positivity.MATERIAL AND METHODS: This is a retrospective analysis of all patients admitted to two tertiary care centers between March 15 andMay 15, 2020, with a diagnosis of COVID-19. From a common database prepared for COVID-19, we retrieved the relevant data andcompared the clinical findings and outcomes of PCR-positive patients with those of PCR-negative cases who had been diagnosed on thebasis of typical clinical and radiographic findings.RESULTS: A total of 349 patients were included in the analysis, of which 126 (36.1%) were PCR-negative. PCR-negative patients wereyounger (54.6 ± 20.8 vs. 60.8 ± 18.9 years, P = .009) but were similar to PCR-positive patients in terms of demographics, comorbidities,and presenting symptoms. They had higher lymphocyte counts (1519 ± 868 vs. 1331 ± 737/mm3, P = .02) and less frequently presentedwith bilateral radiographic findings (68.3% vs. 79.4%, P = .046) than PCR-positive patients. Besides, they had less severe disease andbetter clinical outcomes regarding admission to the intensive care unit (9.6% vs. 20.6%, P = .023), oxygen therapy (21.4% vs. 43.5%, P< .001), ventilatory support (3.2% vs. 11.2%, P = .03) and length of hospital stay (5.0 ± 5.0 vs. 9.7 ± 5.9 days, P < .001).CONCLUSION: This study confirms that about one-third of the COVID-19 patients are PCR-negative and diagnosed based on clinicaland radiographic findings. These patients have a more favorable clinical course, shorter hospital stays, and are less frequently admittedto the intensive care unit.
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