Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia

Çolak, Ayfer; YILMAZ, nisel; TOPRAK, Burak; AKSİL, Merve ZEYTİNLİ

doi:10.1515/tjb-2018-0484

Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia

Ayfer ÇOLAK, (Sağlık Bilimleri Üniversitesi, Tepecik Eğitim ve Araştırma Hastanesi, Tıp Biyokimya Anabilim Dalı, İzmir, Türkiye)

Merve ZEYTİNLİ AKSİL, (Tepecik Eğitim ve Araştırma Hastanesi, Klinik Biyokimya Anabilim Dalı, İzmir, Türkiye)

Burak TOPRAK, (Sivas Eğitim ve Araştırma Hastanesi, Klinik Biyokimya Anabilim Dalı, Sivas, Türkiye)

Nisel YILMAZ (Tepecik Eğitim ve Araştırma Hastanesi, Klinik Mikrobiyoloji Anabilim Dalı, İzmir, Türkiye)

Türk Biyokimya Dergisi

13 3

Yıl: 2020 Cilt: 45 Sayı: 1 Sayfa Aralığı: 57 - 64 Metin Dili: İngilizce DOI: 10.1515/tjb-2018-0484 İndeks Tarihi: 03-10-2021

Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia

Öz:

Objective: The aim of this study is to investigate the diag-nostic accuracy of complete blood count (CBC), C-reactive protein (CRP), and procalcitonin (PCT) levels, which can be used as a cultural alternative for the diagnosis of infec-tion faster.Methods: The patients were divided into two groups as bacteremia (n = 220) and nonbacteremia group (n = 812). The bacteremia group was divided into two subgroups as Gram-positive bacteria (n = 167) and Gram-negative bacte-ria (n = 53).Results: PCT, CRP, red blood cell distribution width (RDW), platelet distribution width (PDW), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), and mean platelet volume (MPV) levels were significantly higher in patients with positive blood culture than non-patients. The serum PCT levels were 3.80 (0.83–37.68) and 0.43 (0.16–2.61) ng/mL, respec-tively (p < 0.001) in the patients with Gram-negative and Gram-positive bacterium. PCT at a cut-off value of 0.45 ng/mL for Gram-negative bacterium; sensitivity of 90% and specificity of 64%.Conclusions: It is important that RDW, PDW, NLR, PLR, MPV values can be measured quickly, easily and cheaply by automatic hematological analysis. However, among the markers tested, PCT has the best diagnostic performance for Gram-negative bacteremia.

Anahtar Kelime:

Bakteriyeminin erken teşhisinde Nötrofil/Lenfosit Oranı, Trombosit/Lenfosit Oranı ve Prokalsitonin tanısal değerleri

Öz:

Amaç: Bu çalışmanın amacı, enfeksiyonun daha hızlıtanısında kültüre alternatif olarak kullanılabilecek tamkan sayımı, C reaktif protein (CRP) ve prokalsitonin (PCT)düzeylerinin tanısal doğruluğunu araştırmaktır. Yöntem: Hastalar bakteriyemi (n = 220) ve bakteriyemiolmayan grup (n = 812) olarak iki gruba ayrıldı. Bakteri- yemi grubu Gram pozitif bakteri (n = 167) ve Gram negatifbakteri (n = 53) olmak üzere iki alt gruba ayrıldı. Bulgular: Kan kültürü pozitif olan hastalarda olmayanlaragöre PCT, CRP, eritrosit dağılım genişliği (RDW), trombo- sit dağılım genişliği (PDW), nötrofil lenfosit oranı (NLR),trombosit lenfosit oranı (PLR) ve ortalama trombosithacmi (MPV) düzeyleri anlamlı olarak yüksek bulundu.Gram -negatif ve Gram- pozitif bakteriyemili hastalardaserum PCT düzeyleri sırasıyla 3.80 (0.83–37.68) ve 0.43(0.16–2.61) ng/mL idi (p < 0.001). Gram negatif bakteri içinPCT 0.45 ng/mL’lik bir kesme değerinde; % 90 duyarlılıkve% 64 özgüllüğe sahipdi. Sonuç: RDW, PDW, NLR, PLR, MPV değerlerinin otoma- tik hematolojik analizlerle hızlı, kolay ve ucuz bir şekildeölçülebilmesi önemlidir. Bununla birlikte, test edilenbelirteçler arasında PCT, gram negatif bakteremi için eniyi teşhis performansına sahiptir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Çolak A, AKSİL M, TOPRAK B, YILMAZ n (2020). Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia. , 57 - 64. 10.1515/tjb-2018-0484
Chicago	Çolak Ayfer,AKSİL Merve ZEYTİNLİ,TOPRAK Burak,YILMAZ nisel Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia. (2020): 57 - 64. 10.1515/tjb-2018-0484
MLA	Çolak Ayfer,AKSİL Merve ZEYTİNLİ,TOPRAK Burak,YILMAZ nisel Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia. , 2020, ss.57 - 64. 10.1515/tjb-2018-0484
AMA	Çolak A,AKSİL M,TOPRAK B,YILMAZ n Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia. . 2020; 57 - 64. 10.1515/tjb-2018-0484
Vancouver	Çolak A,AKSİL M,TOPRAK B,YILMAZ n Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia. . 2020; 57 - 64. 10.1515/tjb-2018-0484
IEEE	Çolak A,AKSİL M,TOPRAK B,YILMAZ n "Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia." , ss.57 - 64, 2020. 10.1515/tjb-2018-0484
ISNAD	Çolak, Ayfer vd. "Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia". (2020), 57-64. https://doi.org/10.1515/tjb-2018-0484

APA	Çolak A, AKSİL M, TOPRAK B, YILMAZ n (2020). Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia. Türk Biyokimya Dergisi, 45(1), 57 - 64. 10.1515/tjb-2018-0484
Chicago	Çolak Ayfer,AKSİL Merve ZEYTİNLİ,TOPRAK Burak,YILMAZ nisel Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia. Türk Biyokimya Dergisi 45, no.1 (2020): 57 - 64. 10.1515/tjb-2018-0484
MLA	Çolak Ayfer,AKSİL Merve ZEYTİNLİ,TOPRAK Burak,YILMAZ nisel Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia. Türk Biyokimya Dergisi, vol.45, no.1, 2020, ss.57 - 64. 10.1515/tjb-2018-0484
AMA	Çolak A,AKSİL M,TOPRAK B,YILMAZ n Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia. Türk Biyokimya Dergisi. 2020; 45(1): 57 - 64. 10.1515/tjb-2018-0484
Vancouver	Çolak A,AKSİL M,TOPRAK B,YILMAZ n Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia. Türk Biyokimya Dergisi. 2020; 45(1): 57 - 64. 10.1515/tjb-2018-0484
IEEE	Çolak A,AKSİL M,TOPRAK B,YILMAZ n "Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia." Türk Biyokimya Dergisi, 45, ss.57 - 64, 2020. 10.1515/tjb-2018-0484
ISNAD	Çolak, Ayfer vd. "Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia". Türk Biyokimya Dergisi 45/1 (2020), 57-64. https://doi.org/10.1515/tjb-2018-0484