Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion

İNAN, SERHAT; Terzi, Yunus Kasım; Sahin, Feride Iffet; ERBERK, Selim Sermed; TÜRKOĞLU BABAKURBAN, Seda

doi:10.1515/tjb-2018-0458

Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion

Serhat İNAN, (Başkent Üniversitesi, Baş Boyun Cerrahisi, Kulak Burun Boğaz Anabilim Dalı, Ankara, Türkiye)

Seda TÜRKOĞLU BABAKURBAN, (Başkent Üniversitesi, Baş Boyun Cerrahisi, Kulak Burun Boğaz Anabilim Dalı, Ankara, Türkiye)

Selim Sermed ERBERK, (Başkent Üniversitesi, Baş Boyun Cerrahisi, Kulak Burun Boğaz Anabilim Dalı, Ankara, Türkiye)

Yunus Kasım TERZİ, (Başkent Üniversitesi, Genetik Tıp Anabilim Dalı, Ankara, Türkiye)

Feride İFFET ŞAHİN (Başkent Üniversitesi, Genetik Tıp Anabilim Dalı, Ankara, Türkiye)

Türk Biyokimya Dergisi

5 0

Yıl: 2020 Cilt: 45 Sayı: 1 Sayfa Aralığı: 44 - 50 Metin Dili: İngilizce DOI: 10.1515/tjb-2018-0458 İndeks Tarihi: 03-10-2021

Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion

Öz:

Background: Adenoid hypertrophy (AH) is one of the pos-sible causes of chronic inflammation in the middle ear. It has been suggested that CX3CL1 and its specific receptor (CX3CR1) could be related with the pathogenesis of some inflammatory diseases. The aim of the present study was to evaluate the role of CX3CL1 and CX3CR1 in the patho-genesis of AH with chronic otitis media with effusion (COME) in children.Materials and methods: Adenoid tissue samples were obtained from 91 pediatric patients and divided into two groups: adenoidectomy only for AH (n: 47) and adenoid-ectomy in conjunction with ventilation tube insertion for AH + COME (n: 44). Expression levels of CX3CL1 and CX3CR1 genes were compared.Results: Expression levels of CX3CL1 and CX3CR1 in hyper-trophic adenoid tissue were not significantly different between the AH + COME and AH only groups. Although no significant difference was detected in the expression of CX3CL1 in the adenoid samples, the expression of CX3CR1 was higher in children older than 48 months.Conclusions: When allergy, atopy and chronic adenoiditis does not exist to obstructive adenoid hypertrophy, inflam-matory fractalkine chemokine expression levels in ade-noid tissue was not observed to be increased in children with COME.

Anahtar Kelime:

Adenoid hipertrofisi ve kronik efüzyonlu otitis mediası olan çocuklarda Fraktalkin (CX3CL1) ve reseptörü (CX3CR1)

Öz:

Amaç: Adenoid hipertrofisi (AH), orta kulaktaki kronikinflamasyonun olası sebeplerinden biridir. CX3CL1 ve spe- sifik reseptörünün (CX3CR1) bazı inflamatuar hastalıkla- rın patogenezi ile ilişkili olabileceği öne sürülmektedir. Buçalışmanın amacı, CX3CL1 ve CX3CR1’ in çocuklarda AHve kronik efüzyonlu otitis media (KEOM) patogenezindekirolünü değerlendirmektir. Gereç ve Yöntemler: Adenoid doku örnekleri 91 pediatrikhastadan alındı ve yalnız AH (n: 47) için adenoidektomive AH + KEOM (n: 44) için adenoidektomi ile birlikte ven- tilasyon tüpü tatbiki uygulananlar olmak üzere iki grubaayrıldı. CX3CL1 ve CX3CR1 genlerinin ekspresyon düzey- leri karşılaştırıldı. Bulgular: Hipertrofik adenoid dokusundaki CX3CL1ve CX3CR1 ekspresyon düzeyleri, yalnız AH grubu ileAH + KEOM grubu arasında anlamlı farklılık göstermedi. Adenoid örneklerinde CX3CR1 ekspresyonu 48 aydandaha büyük çocuklarda daha yüksekti, CX3CL1 ekspres- yonunda ise anlamlı bir farklılık bulunmadı. Sonuç: Obstrüktif adenoid hipertrofisine alerji, atopi vekronik adenoidit eşlik etmediği KEOM’ li çocuklarda ade- noid dokusundaki enflamatuar fraktalkin kemokinininekspresyon düzeyinde artış olmadığı gözlenmektedir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	İNAN S, TÜRKOĞLU BABAKURBAN S, ERBERK S, Terzi Y, Sahin F (2020). Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion. , 44 - 50. 10.1515/tjb-2018-0458
Chicago	İNAN SERHAT,TÜRKOĞLU BABAKURBAN Seda,ERBERK Selim Sermed,Terzi Yunus Kasım,Sahin Feride Iffet Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion. (2020): 44 - 50. 10.1515/tjb-2018-0458
MLA	İNAN SERHAT,TÜRKOĞLU BABAKURBAN Seda,ERBERK Selim Sermed,Terzi Yunus Kasım,Sahin Feride Iffet Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion. , 2020, ss.44 - 50. 10.1515/tjb-2018-0458
AMA	İNAN S,TÜRKOĞLU BABAKURBAN S,ERBERK S,Terzi Y,Sahin F Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion. . 2020; 44 - 50. 10.1515/tjb-2018-0458
Vancouver	İNAN S,TÜRKOĞLU BABAKURBAN S,ERBERK S,Terzi Y,Sahin F Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion. . 2020; 44 - 50. 10.1515/tjb-2018-0458
IEEE	İNAN S,TÜRKOĞLU BABAKURBAN S,ERBERK S,Terzi Y,Sahin F "Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion." , ss.44 - 50, 2020. 10.1515/tjb-2018-0458
ISNAD	İNAN, SERHAT vd. "Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion". (2020), 44-50. https://doi.org/10.1515/tjb-2018-0458

APA	İNAN S, TÜRKOĞLU BABAKURBAN S, ERBERK S, Terzi Y, Sahin F (2020). Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion. Türk Biyokimya Dergisi, 45(1), 44 - 50. 10.1515/tjb-2018-0458
Chicago	İNAN SERHAT,TÜRKOĞLU BABAKURBAN Seda,ERBERK Selim Sermed,Terzi Yunus Kasım,Sahin Feride Iffet Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion. Türk Biyokimya Dergisi 45, no.1 (2020): 44 - 50. 10.1515/tjb-2018-0458
MLA	İNAN SERHAT,TÜRKOĞLU BABAKURBAN Seda,ERBERK Selim Sermed,Terzi Yunus Kasım,Sahin Feride Iffet Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion. Türk Biyokimya Dergisi, vol.45, no.1, 2020, ss.44 - 50. 10.1515/tjb-2018-0458
AMA	İNAN S,TÜRKOĞLU BABAKURBAN S,ERBERK S,Terzi Y,Sahin F Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion. Türk Biyokimya Dergisi. 2020; 45(1): 44 - 50. 10.1515/tjb-2018-0458
Vancouver	İNAN S,TÜRKOĞLU BABAKURBAN S,ERBERK S,Terzi Y,Sahin F Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion. Türk Biyokimya Dergisi. 2020; 45(1): 44 - 50. 10.1515/tjb-2018-0458
IEEE	İNAN S,TÜRKOĞLU BABAKURBAN S,ERBERK S,Terzi Y,Sahin F "Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion." Türk Biyokimya Dergisi, 45, ss.44 - 50, 2020. 10.1515/tjb-2018-0458
ISNAD	İNAN, SERHAT vd. "Fractalkine (CX3CL1) and its receptor(CX3CR1) in children with hypertrophic adenoidand chronic otitis media with effusion". Türk Biyokimya Dergisi 45/1 (2020), 44-50. https://doi.org/10.1515/tjb-2018-0458