The distribution indices of erythrocytes:which one for acute ischemic stroke?

Günay, Nurullah; Ekici Gunay, Nahide

doi:10.1515/tjb-2019-0103

The distribution indices of erythrocytes:which one for acute ischemic stroke?

Nahide GÜNAY, (Kayseri Şehir Eğitim ve Araştırma Hastanesi, Sağlık Bilimleri Üniversitesi, Klinik Biyokimya Anabilim Dalı, Kayseri, Türkiye)

Nurullah GÜNAY (Erciyes Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Kayseri, Türkiye)

Türk Biyokimya Dergisi

5 1

Yıl: 2020 Cilt: 45 Sayı: 1 Sayfa Aralığı: 65 - 75 Metin Dili: İngilizce DOI: 10.1515/tjb-2019-0103 İndeks Tarihi: 03-10-2021

The distribution indices of erythrocytes:which one for acute ischemic stroke?

Öz:

Background: The erythrocytes distribution indices are reported from same histogram but they have different ref-erence intervals and calculated by distinct measurements.Objectives: To explore whether the RDW-CV and RDW-SD values may predictive and prognostic significance in ischemic stroke patients and to clarify the relation each of these indices with stroke severity and 3-months survival.Materials and methods: Cumulative survival rates were calculated with the Kaplan-Meier method, and life curves were compared to RDW-CV, RDW-SD quartiles. The risk factors were described with a multivariable cox propor-tional hazard model.Results: In acute ischemic stroke, RDW-CV was more spe-cific and RDW-SD was more sensitive (92% vs. 80%) (52% vs. 48%). RDW-CV values higher than 14.7% are associ-ated with 11-fold increase in the risk of stroke; and the level of RDW-CV does show a linear relationship with the severity of stroke. However, when we evaluated RDW-SD, higher 43.55 fL RDW-SD values was have 16-fold increase in severity of stroke and have a relatively high linear rela-tionship with stroke severity scores to RDW-CV.Conclusions: RDW-CV and RDW-SD levels have different prognostic poor outcomes for interpreting in ischemic stroke events approach and these should be used alone and com-paratively with the AIS predictive and prognostic approach.

Anahtar Kelime:

Eritrosit dağılım indeksleri: Akut iskemik inmeiçin hangisi?

Öz:

Amaç: Eritrosit dağılım indeksleri (RDW-CV ve RDW-SD)aynı histogram grafiğinden rapor edilir. Ancak bunla- rın farklı referans aralıkları vardır ve farklı ölçümlerlehesaplanırlar. Bu çalışmada, iskemik inme hastalarındaeritrosit indekslerinin öngörücü ve prognostik önemiolup olmadığını araştırmak, bu indekslerin her birinininme şiddeti ve 3 aylık sağkalım ile ilişkisini incelemeamaçlandı. Gereç ve Yöntem: Multivariable Cox regresyon hazardmodeli ile iskemik inme için risk faktörleri tanımlandı.Kaplan-Meier yöntemi ile kümülatif sağkalım oranlarıhesaplandı ve RDW-CV ve RDW-SD çeyreklerine göreyaşam eğrileri ile karşılaştırıldı. Bulgular: Akut iskemik inmede RDW-CV daha spesifiktirve RDW-SD daha duyarlıdır (sırasıyla% 92 ve % 80) (% 52ve % 48). %14,7’den yüksek RDW-CV değerleri inme ris- kindeki 11 kat artışla ilişkiliydi ve inme ciddiyeti ile doğ- rusal bir ilişki göstermektedir. 43.55 fL üzerindeki RDW-SDdeğerleri 16 kat daha yüksek tehlike oranlarına sahiptir veRDW-CV’ye göre inme şiddeti skorları ile daha yüksek birdoğrusal ilişki göstermektedir. Sonuç: RDW-CV ve RDW-SD düzeyleri iskemik inmeyeyaklaşımda farklı prognostik kötü sonuçlara sahiptir. Buindeksler AIS öngörücü ve prognostik yaklaşımda tekbaşına ve karşılaştırmalı olarak kullanılmalıdırlar.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Ekici Gunay N, Günay N (2020). The distribution indices of erythrocytes:which one for acute ischemic stroke?. , 65 - 75. 10.1515/tjb-2019-0103
Chicago	Ekici Gunay Nahide,Günay Nurullah The distribution indices of erythrocytes:which one for acute ischemic stroke?. (2020): 65 - 75. 10.1515/tjb-2019-0103
MLA	Ekici Gunay Nahide,Günay Nurullah The distribution indices of erythrocytes:which one for acute ischemic stroke?. , 2020, ss.65 - 75. 10.1515/tjb-2019-0103
AMA	Ekici Gunay N,Günay N The distribution indices of erythrocytes:which one for acute ischemic stroke?. . 2020; 65 - 75. 10.1515/tjb-2019-0103
Vancouver	Ekici Gunay N,Günay N The distribution indices of erythrocytes:which one for acute ischemic stroke?. . 2020; 65 - 75. 10.1515/tjb-2019-0103
IEEE	Ekici Gunay N,Günay N "The distribution indices of erythrocytes:which one for acute ischemic stroke?." , ss.65 - 75, 2020. 10.1515/tjb-2019-0103
ISNAD	Ekici Gunay, Nahide - Günay, Nurullah. "The distribution indices of erythrocytes:which one for acute ischemic stroke?". (2020), 65-75. https://doi.org/10.1515/tjb-2019-0103

APA	Ekici Gunay N, Günay N (2020). The distribution indices of erythrocytes:which one for acute ischemic stroke?. Türk Biyokimya Dergisi, 45(1), 65 - 75. 10.1515/tjb-2019-0103
Chicago	Ekici Gunay Nahide,Günay Nurullah The distribution indices of erythrocytes:which one for acute ischemic stroke?. Türk Biyokimya Dergisi 45, no.1 (2020): 65 - 75. 10.1515/tjb-2019-0103
MLA	Ekici Gunay Nahide,Günay Nurullah The distribution indices of erythrocytes:which one for acute ischemic stroke?. Türk Biyokimya Dergisi, vol.45, no.1, 2020, ss.65 - 75. 10.1515/tjb-2019-0103
AMA	Ekici Gunay N,Günay N The distribution indices of erythrocytes:which one for acute ischemic stroke?. Türk Biyokimya Dergisi. 2020; 45(1): 65 - 75. 10.1515/tjb-2019-0103
Vancouver	Ekici Gunay N,Günay N The distribution indices of erythrocytes:which one for acute ischemic stroke?. Türk Biyokimya Dergisi. 2020; 45(1): 65 - 75. 10.1515/tjb-2019-0103
IEEE	Ekici Gunay N,Günay N "The distribution indices of erythrocytes:which one for acute ischemic stroke?." Türk Biyokimya Dergisi, 45, ss.65 - 75, 2020. 10.1515/tjb-2019-0103
ISNAD	Ekici Gunay, Nahide - Günay, Nurullah. "The distribution indices of erythrocytes:which one for acute ischemic stroke?". Türk Biyokimya Dergisi 45/1 (2020), 65-75. https://doi.org/10.1515/tjb-2019-0103