The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice
Yıl: 2021 Cilt: 27 Sayı: 3 Sayfa Aralığı: 355 - 361 Metin Dili: İngilizce DOI: 10.9775/kvfd.2021.25525 İndeks Tarihi: 04-10-2021
The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice
Öz: The purpose of this study was to investigate the effi cacy of synovial fl uid (SF) as a source of hyaluronic acid (HA) on Limberg and Elliptical rotationfl ap healing. In this study conducted on 24 male Mus musculus mice, the animals were divided into 2 main groups. Group 1 (n = 12): Limbergfl apgroup; Group 2 (n = 12) Elliptical rotation fl ap group. Six of the animals in Group 1 and Group 2 were assigned as the Flap (Control) Group, and 6 asthe Flap + SF Group. In SF subgroups of animals in each group, 1 mL SF was injected into the operation area in addition to the fl ap surgical procedure.The groups were compared in terms of epithelialization, angiogenesis, neutrophil leukocyte infiltration and fibroblast activity, and the eff ect of SFon the infl ammation and wound healing was evaluated. It was observed that epithelization was completed in all animals in the groups which wereadministered compared to the other groups, and there was a statistically significant diff erence (P<0.05). In addition, no necrosis or abscess wasfound in the groups which were administered SF. There was no statistical diff erence in the paired comparisons of neutrophil-leukocyte infiltrationand fibroblast activity parameters. Although the Limberg fl ap technique is more commonly used today, it can be said that elliptical rotation fl ap isa method that can be used in routine practice due to a lower complication rate. However, SF increases epithelization and plays a regulatory role onangiogenesis. Therefore, it is concluded that the use of SF as a source of HA in combination with elliptical rotation fl ap in wounds with material tissueloss will contribute to clinical practice.
Anahtar Kelime: Doğal Bir Hyaluronik Asit Kaynağı Olarak Sinovyal Sıvının Limberg Flep ve Eliptik Rotasyon Flep İyileşmesi Üzerine Etkisi: Farelerde Tam Katmanlı Eksizyonel Dermal Yaralarda Karşılaştırmalı Bir Çalışma
Öz: Bu çalışmada, doğal bir hyaluronik asit (HA) kaynağı olarak sinovyal sıvının (SS) Limberg ve Eliptik rotasyon fl ep iyileşmesi üzerine etkinliğinin araştırılması amaçlandı. Yirmi dört adet erkek Mus musculus cinsi fare üzerinde yapılan bu çalışmada hayvanlar 2 ana gruba ayrıldı. Grup 1 (n=12): Limberg fl ep grubu; Grup 2 (n=12) Eliptik rotasyon fl ep grubu. Grup 1 ve Grup 2’deki hayvanların 6’sı Flep (Kontrol) Grubu, 6’sı ise Flep + SS Grubu olarak ayrıldı. Her bir gruptaki hayvanların SS alt gruplarında fl ep cerrahi prosedürüne ek olarak operasyon bölgesine 1 mL SS enjekte edildi. Epitelizasyon, anjiyogenezis, nötrofil lökosit infiltrasyonu ve fibroblast aktivitesi yönünden gruplar karşılaştırılarak SS’nın fl ep viabilitesi ve yara iyileşmesine olan etkisi değerlendirildi. SS uygulanan gruplarda hayvanların tamamında, diğer gruplara göre epitelizasyonun tamamlandığı ve istatistiksel olarak anlamlı farklılık olduğu görüldü (P<0.05). Ayrıca, SS verilen gruplarda nekroz ve apseye rastlanmadı. Nötrofil-lökosit infiltrasyonu ve fibroblast aktivitesi parametrelerindeki ikili karşılaştırılmalarda ise istatistiksel fark saptanmadı. Limberg fl ep tekniği günümüzde daha çok uygulanıyor olsa da eliptik rotasyon fl ebinde komplikasyonun daha az olması nedeniyle rutinde uygulanabilecek bir yöntem olduğu söylenebilir. Bununla birlikte SS, epitelizasyonu arttırmakta ve angiogenezis üzerinde düzenleyici rol üstlenmektedir. Bu sebeplerle, bir HA kaynağı olarak SS’nın, maddi doku kayıplı yaralarda eliptik rotasyon fl ebi ile birlikte kullanımının klinik pratiğe katkı sağlayacağı belirlenmiştir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | Cantay H, anuk t, AYDIN U, Karakurt E, Yıldız U, NUHOĞLU H (2021). The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice. , 355 - 361. 10.9775/kvfd.2021.25525 |
Chicago | Cantay Hasan,anuk turgut,AYDIN UGUR,Karakurt Emin,Yıldız Uğur,NUHOĞLU HİLMİ The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice. (2021): 355 - 361. 10.9775/kvfd.2021.25525 |
MLA | Cantay Hasan,anuk turgut,AYDIN UGUR,Karakurt Emin,Yıldız Uğur,NUHOĞLU HİLMİ The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice. , 2021, ss.355 - 361. 10.9775/kvfd.2021.25525 |
AMA | Cantay H,anuk t,AYDIN U,Karakurt E,Yıldız U,NUHOĞLU H The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice. . 2021; 355 - 361. 10.9775/kvfd.2021.25525 |
Vancouver | Cantay H,anuk t,AYDIN U,Karakurt E,Yıldız U,NUHOĞLU H The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice. . 2021; 355 - 361. 10.9775/kvfd.2021.25525 |
IEEE | Cantay H,anuk t,AYDIN U,Karakurt E,Yıldız U,NUHOĞLU H "The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice." , ss.355 - 361, 2021. 10.9775/kvfd.2021.25525 |
ISNAD | Cantay, Hasan vd. "The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice". (2021), 355-361. https://doi.org/10.9775/kvfd.2021.25525 |
APA | Cantay H, anuk t, AYDIN U, Karakurt E, Yıldız U, NUHOĞLU H (2021). The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 27(3), 355 - 361. 10.9775/kvfd.2021.25525 |
Chicago | Cantay Hasan,anuk turgut,AYDIN UGUR,Karakurt Emin,Yıldız Uğur,NUHOĞLU HİLMİ The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 27, no.3 (2021): 355 - 361. 10.9775/kvfd.2021.25525 |
MLA | Cantay Hasan,anuk turgut,AYDIN UGUR,Karakurt Emin,Yıldız Uğur,NUHOĞLU HİLMİ The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.27, no.3, 2021, ss.355 - 361. 10.9775/kvfd.2021.25525 |
AMA | Cantay H,anuk t,AYDIN U,Karakurt E,Yıldız U,NUHOĞLU H The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2021; 27(3): 355 - 361. 10.9775/kvfd.2021.25525 |
Vancouver | Cantay H,anuk t,AYDIN U,Karakurt E,Yıldız U,NUHOĞLU H The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2021; 27(3): 355 - 361. 10.9775/kvfd.2021.25525 |
IEEE | Cantay H,anuk t,AYDIN U,Karakurt E,Yıldız U,NUHOĞLU H "The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 27, ss.355 - 361, 2021. 10.9775/kvfd.2021.25525 |
ISNAD | Cantay, Hasan vd. "The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 27/3 (2021), 355-361. https://doi.org/10.9775/kvfd.2021.25525 |