Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features

Kültür, Turgut; zengin, Mehmet

doi:10.46497/ArchRheumatol.2021.8242

Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features

Turgut KÜLTÜR, (Kırıkkale Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Kırıkkale, Türkiye)

Mehmet ZENGİN (Kırıkkale Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Kırıkkale, Türkiye)

Archives of Rheumatology

2 0

Yıl: 2021 Cilt: 36 Sayı: 2 Sayfa Aralığı: 192 - 200 Metin Dili: İngilizce DOI: 10.46497/ArchRheumatol.2021.8242 İndeks Tarihi: 29-09-2021

Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features

Öz:

Objectives: This study aims to investigate the relationship between estrogen receptors (ERs) and progesterone receptors (PRs) and histopathologicalfindings in synovial tissue in rheumatoid arthritis (RA) and osteoarthritis (OA) patients.Patients and methods: Synovial tissue samples obtained from synovial surgery from 30 RA (10 males, 20 females) and 92 OA (27 males, 65 females)patients with median age of 59 (range, 50 to 67) years were analyzed retrospectively between January 2010 and January 2019. The relationshipbetween histopathological features and hormone receptor presence was analyzed.Results: There was a meaningful relationship between histopathological parameters and RA and OA (p=0.01). The sex hormone receptor'spresence was significantly higher in females with RA (p=0.01). Additionally, in the RA group, there was a remarkable relationship between ER andfocal aggregates of lymphocytes (p=0.01), perivascular infiltrates of lymphocytes (p=0.03), and diffuse infiltrates of lymphocytes (p=0.01). In theOA group, a significant relationship was observed between PR and subchondral inflammation (p=0.01). In multivariate analysis, it was observed thatER was an independent risk factor for focal aggregates of lymphocytes in RA group (odds ratio [OR]=1.51 [1.02-2.25], p=0.04). Besides, PR was foundto be an independent risk factor for subchondral inflammation in OA group (OR=3.90 [1.28-11.80], p=0.02).Conclusion: The presence of the sex hormone receptor in the synovium may change histopathological features and affect the clinical course.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Firestein GS, Budd RC, Gabriel SE, McInnes IB, O’Dell JR, editors. Kelley and Firestein's Textbook of Rheumatology. 9th ed. Philadelphia, Elsevier; 2016.
2. Jin X, Wang BH, Wang X, Antony B, Zhu Z, Han W, et al. Associations between endogenous sex hormones and MRI structural changes in patients with symptomatic knee osteoarthritis. Osteoarthritis Cartilage 2017;25:1100-6.
3. McCulloch K, McGrath S, Huesa C, Dunning L, Litherland G, Crilly A, et al. Rheumatic Disease: Protease-Activated Receptor-2 in Synovial Joint Pathobiology. Front Endocrinol (Lausanne) 2018;9:257.
4. Ortona E, Pierdominici M, Maselli A, Veroni C, Aloisi F, Shoenfeld Y. Sex-based differences in autoimmune diseases. Ann Ist Super Sanita 2016;52:205-12.
5. Martocchia A, Stefanelli M, Cola S, Falaschi P. Sex steroids in autoimmune diseases. Curr Top Med Chem 2011;11:1668-83.
6. Rooney M, Condell D, Quinlan W, Daly L, Whelan A, Feighery C, et al. Analysis of the histologic variation of synovitis in rheumatoid arthritis. Arthritis Rheum 1988;31:956-63.
7. Gardner DL, Salter DM, Oates K. Advances in the microscopy of osteoarthritis. Microsc Res Tech 1997;37:245-70.
8. Matos LL, Trufelli DC, de Matos MG, da Silva Pinhal MA. Immunohistochemistry as an important tool in biomarkers detection and clinical practice. Biomark Insights 2010;5:9-20.
9. Jimenez-Boj E, Nöbauer-Huhmann I, Hanslik-Schnabel B, Dorotka R, Wanivenhaus AH, Kainberger F, et al. Bone erosions and bone marrow edema as defined by magnetic resonance imaging reflect true bone marrow inflammation in rheumatoid arthritis. Arthritis Rheum 2007;56:1118-24.
10. Pablos JL, Santiago B, Tsay D, Singer MS, Palao G, Galindo M, et al. A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-alpha/beta and TNFalpha in cultured endothelial cells. BMC Immunol 2005;6:6.
11. Veale DJ, Orr C, Fearon U. Cellular and molecular perspectives in rheumatoid arthritis. Semin Immunopathol 2017;39:343-54.
12. Dubikov AI, Kalinichenko SG. Small molecules regulating apoptosis in the synovium in rheumatoid arthritis. Scand J Rheumatol 2010;39:368-72.
13. Manca ML, Lattuada D, Valenti D, Marelli O, Corradini C, Fernàndez-Busquets X, et al. Potential therapeutic effect of curcumin loaded hyalurosomes against inflammatory and oxidative processes involved in the pathogenesis of rheumatoid arthritis: The use of fibroblast-like synovial cells cultured in synovial fluid. Eur J Pharm Biopharm 2019;136:84-92.
14. Hirohata S, Abe A, Murasawa A, Kanamono T, Tomita T, Yoshikawa H. Differential effects of IL-6 blockade tocilizumab and TNF inhibitors on angiogenesis in synovial tissues from patients with rheumatoid arthritis. Mod Rheumatol 2017;27:766-72.
15. Chien SY, Tsai CH, Liu SC, Huang CC, Lin TH, Yang YZ, et al. Noggin Inhibits IL-1b and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis. Cells 2020;9:927.
16. Zierau O, Zenclussen AC, Jensen F. Role of female sex hormones, estradiol and progesterone, in mast cell behavior. Front Immunol 2012;3:169.
17. Wardhana, Surachmanto EE, Datau EA, Ongkowijaya J, Karema-Kaparang AM. Transdermal bio-identical progesterone cream as hormonal treatment for osteoarthritis. Acta Med Indones 2013;45:224-32.
18. Watanabe H, Takahashi K, Ishii H, Iizawa N, Kawaji H, Majima T, et al. Association between steroid hormone receptors expression in the synovium and body mass index in human osteoarthritis. Osteoarthritis and Cartilage 2016;24:S68-S9.
19. Jin X, Wang BH, Wang X, Antony B, Zhu Z, Han W, et al. Associations between endogenous sex hormones and MRI structural changes in patients with symptomatic knee osteoarthritis. Osteoarthritis Cartilage 2017;25:1100-6.

APA	Kültür T, zengin M (2021). Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features. , 192 - 200. 10.46497/ArchRheumatol.2021.8242
Chicago	Kültür Turgut,zengin Mehmet Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features. (2021): 192 - 200. 10.46497/ArchRheumatol.2021.8242
MLA	Kültür Turgut,zengin Mehmet Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features. , 2021, ss.192 - 200. 10.46497/ArchRheumatol.2021.8242
AMA	Kültür T,zengin M Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features. . 2021; 192 - 200. 10.46497/ArchRheumatol.2021.8242
Vancouver	Kültür T,zengin M Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features. . 2021; 192 - 200. 10.46497/ArchRheumatol.2021.8242
IEEE	Kültür T,zengin M "Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features." , ss.192 - 200, 2021. 10.46497/ArchRheumatol.2021.8242
ISNAD	Kültür, Turgut - zengin, Mehmet. "Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features". (2021), 192-200. https://doi.org/10.46497/ArchRheumatol.2021.8242

APA	Kültür T, zengin M (2021). Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features. Archives of Rheumatology, 36(2), 192 - 200. 10.46497/ArchRheumatol.2021.8242
Chicago	Kültür Turgut,zengin Mehmet Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features. Archives of Rheumatology 36, no.2 (2021): 192 - 200. 10.46497/ArchRheumatol.2021.8242
MLA	Kültür Turgut,zengin Mehmet Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features. Archives of Rheumatology, vol.36, no.2, 2021, ss.192 - 200. 10.46497/ArchRheumatol.2021.8242
AMA	Kültür T,zengin M Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features. Archives of Rheumatology. 2021; 36(2): 192 - 200. 10.46497/ArchRheumatol.2021.8242
Vancouver	Kültür T,zengin M Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features. Archives of Rheumatology. 2021; 36(2): 192 - 200. 10.46497/ArchRheumatol.2021.8242
IEEE	Kültür T,zengin M "Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features." Archives of Rheumatology, 36, ss.192 - 200, 2021. 10.46497/ArchRheumatol.2021.8242
ISNAD	Kültür, Turgut - zengin, Mehmet. "Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features". Archives of Rheumatology 36/2 (2021), 192-200. https://doi.org/10.46497/ArchRheumatol.2021.8242