Serum progranulin to TNF-α ratio in patients with gonarthrosis

Boy, Fatih; YILDIZ, Kadri

doi:10.5152/j.aott.2021.19249

Serum progranulin to TNF-α ratio in patients with gonarthrosis

Kadri YILDIZ, (Kafkas Üniversitesi, Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Kars, Türkiye)

Fatih BOY (Kafkas Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Kars, Türkiye)

Acta Orthopaedica et Traumatologica Turcica

2 0

Yıl: 2021 Cilt: 55 Sayı: 3 Sayfa Aralığı: 235 - 238 Metin Dili: İngilizce DOI: 10.5152/j.aott.2021.19249 İndeks Tarihi: 29-09-2021

Serum progranulin to TNF-α ratio in patients with gonarthrosis

Öz:

Objective: Progranulin (PGRN) is a growth factor that has antiinflammatory, immunosuppressive, and chondroprotective effects.It blocks Tumor Necrosis Factor-α (TNF-α) signal pathway by binding its receptor. Recently, it has been claimed that PGRN maybe overexpressed in patients with Osteoarthritis (OA). However, these patients tend to be obese and obesity also may be one ofthe factors that affect PGRN levels. The aim of this study was to compare the PGRN levels of patients with Knee OA (KOA) withthat of healthy controls by eliminating the effect of obesity and to evaluate PGRN-to-Tumor Necrosis Factor-α (TNF-α) ratio inKOA, both of which were investigated first in literature by this study.Methods: A total of 80 individuals (40 patients with KOA and 40 healthy controls) were included in this study. The patients andcontrols were divided into two groups according to their Body Mass Indexes (BMI): nonobese (BMI between 18.5 and 24.9) andobese (BMI of 30 or higher). Each of the groups included 20 subjects and had an equal number of men and women. Blood sampleswere obtained from all participants, and the serum PGRN and TNF-α levels were measured using commercial ELISA kits.Results: There was no difference among groups in terms of age (P = 0.416) and gender distribution. There was no statisticaldifference among study groups with regard to serum PGRN levels. Serum TNF-α levels were significantly higher in obesecontrols (P < 0.001) and nonobese patients (P = 0.003) compared to that of nonobese healthy controls. Correspondingly, serumPGRN-to-TNF-α ratio was considerably lower in obese controls (P < 0.001) and nonobese patients (P < 0.001) by comparison withthat of nonobese healthy controls.Conclusion: We determined that both obesity and KOA increased serum TNF-α levels and concordantly decreased serum PGRNto-TNF-α ratio. The results of the study suggest that the activation of the PGRN pathway and/or the inhibition of the TNFαpathway may be essential in terms of the reestablishment of the disrupted inflammatory balance in patients with KOA.Level of Evidence: Level III, Diagnostic study

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik

1. Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019;393(10182):1745- 1759. 10.1016/S0140-6736(19)30417-9
2. O’Neill TW, McCabe PS, McBeth J. Update on the epidemiology, risk factors and disease outcomes of osteoarthritis. Best Pract Res Clin Rheumatol. 2018;32 (2):312-326. 10.1016/j.berh.2018.10.007
3. Thomas AC, Hubbard-Turner T, Wikstrom EA, Palmieri-Smith RM. Epidemiology of posttraumatic osteoarthritis. J Athl Train. 2017;52(6):491-496. 10.4085/ 1062-6050-51.5.08
4. Carrion M, Frommer KW, Perez-Garcia S, Müller-Ladner U, Gomariz RP, Neumann E. The adipokine network in rheumatic joint diseases. Int J Mol Sci. 2019;20(17):E4091. 10.3390/ijms20174091
5. Abella V, Scotece M, Conde J, et al. The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1. Sci Rep. 2016;6:20356. 10.1038/srep20356
6. Wang T, He C. Pro-inflammatory cytokines: The link between obesity and osteoarthritis. Cytokine Growth Factor Rev. 2018;44:38-50. 10.1016/j.cytogfr. 2018.10.002
7. Nadro B, Sztanek F, Lorincz H, Pall D, Paragh G, Harangi M. Diagnostic and prognostic roles of serum progranulin, a novel marker of the carbohydrate metabolism and inflammation. Orv Hetil. 2019;160(25):973-979. 10.1556/650. 2019.31356
8. Mora JC, Przkora R, Cruz-Almeida Y. Knee osteoarthritis: Pathophysiology and current treatment modalities. J Pain Res. 2018;11:2189-2196. 10.2147/JPR. S154002
9. Cerezo LA, Kuklova M, Hulejova H, et al. Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis. Mediators Inflamm. 2015;2015:740357. 10.1155/2015/740357
10. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957;16(4):494-502. 10.1136/ard.16.4.494
11. Schmid A, Hochberg A, Kreiß AF, et al. Role of progranulin in adipose tissue innate immunity. Cytokine. 2020;125:154796. 10.1016/j.cyto.2019.154796
12. Wang F, Chen T, Sun L, et al. Circulating PGRN levels are increased but not associated with insulin sensitivity or β-cell function in Chinese obese children. Dis Markers. 2018;2018:3729402. 10.1155/2018/3729402
13. Alissa EM, Sutaih RH, Kamfar HZ, Alagha AE, Marzouki ZM. Serum progranulin levels in relation to insulin resistance in childhood obesity. J Pediatr Endocrinol Metab. 2017;30(12):1251-1256. 10.1515/jpem-2017-0321
14. Gorkem U, Inal ZO, Inal HA, Bostanci MO. Serum progranulin levels are elevated in infertile women with obesity. Endokrynol Pol. 2018;69(6):661-666. 10.5603/EP.a2018.0044
15. Milajerdi A, Maghbooli Z, Mohammadi F, Hosseini B, Mirzaei K. Progranulin concentration in relation to bone mineral density among obese individuals. Arch Endocrinol Metab. 2018;62(2):179-186. 10.20945/2359-3997000000022
16. Brock J, Schmid A, Karrasch T, et al. Progranulin serum levels and gene expression in subcutaneous vs visceral adipose tissue of severely obese patients undergoing bariatric surgery. Clin Endocrinol (Oxf). 2019;91(3):400-410. 10. 1111/cen.14040
17. Niklowitz P, Rothermel J, Lass N, Barth A, Reinehr T. Is there a link between progranulin, obesity, and parameters of the metabolic syndrome in children? Findings from a longitudinal intervention study. Pediatr Diabetes. 2019;20 (8):1047-1055. 10.1111/pedi.12915
18. Archer M, Niemela O, Hamalainen M, Moilanen E, Leinonen E, Kampman O. The effects of adiposity and alcohol use disorder on adipokines and biomarkers of inflammation in depressed patients. Psychiatry Res. 2018;264:31-38. 10. 1016/j.psychres.2018.03.073
19. Ebert T, Gebhardt C, Scholz M, et al. Relationship between 12 adipocytokines and distinct components of the metabolic syndrome. J Clin Endocrinol Metab. 2018;103(3):1015-1023. 10.1210/jc.2017-02085
20. Kotela A, Wojdasiewicz P, Legosz P, et al. Increased serum levels of progranulin (PGRN) in patients with haemophilic arthropathy. Clin Exp Pharmacol Physiol. 2018. 10.1111/1440-1681.13054
21. Guo F, Lai Y, Tian Q, Lin EA, Kong L, Liu C. Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein. Arthritis Rheum. 2010;62(7):2023-2036. 10.1002/art.27491
22. Yamamoto Y, Takemura M, Serrero G, et al. Increased serum GP88 (progranulin) concentrations in rheumatoid arthritis. Inflammation. 2014;37(5):1806- 1813. 10.1007/s10753-014-9911-4
23. Atawia RT, Bunch KL, Toque HA, Caldwell RB, Caldwell RW. Mechanisms of obesity-induced metabolic and vascular dysfunctions. Front Biosci (Landmark Ed). 2019;24:890-934. 10.2741/4758
24. Özler K, Aktaş E, Atay Ç, Yılmaz B, Arıkan M, Güngör Ş. Serum and knee synovial fluid matrixmetalloproteinase-13 and tumor necrosis factor-alpha levels in patients with late stage osteoarthritis. Acta Orthop Traumatol Turc. 2016;50(3):356-361. 10.1016/j.aott.2015.11.003
25. Xie C, Chen Q. Adipokines: New therapeutic target for osteoarthritis? Curr Rheumatol Rep. 2019;21(12):71. 10.1007/s11926-019-0868-z
26. Tang W, Lu Y, Tian QY, et al. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science. 2011;332(6028):478-484. 10.1126/science.1199214
27. Wei JL, Buza J3rd, Liu CJ. Does progranulin account for the opposite effects of etanercept and infliximab/adalimumab in osteoarthritis? J Orthop Res. 2016;34 (1):12-14. 10.1002/jor.23091
28. Zhao Y, Liu B, Liu CJ. Establishment of a surgically-induced model in mice to investigate the protective role of progranulin in osteoarthritis. J Vis Exp. 2014;84:e50924. 10.3791/50924
29. Zhao YP, Liu B, Tian QY, Wei JL, Richbourgh B, Liu CJ. Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling. Ann Rheum Dis. 2015;74(12):2244-2253. 10.1136/annrheumdis-2014-205779
30. Xia Q, Zhu S, Wu Y, et al. Intra-Articular Transplantation of Atsttrin-Transduced Mesenchymal Stem Cells Ameliorate Osteoarthritis Development. Stem Cells Transl Med. 2015;4(5):523-531. 10.5966/sctm.2014-0200
31. Lau TT, Zhang F, Tang W, Wang DA. Release of transgenic progranulin from a living hyaline cartilage graft model: An in vitro evaluation on anti-inflammation. J Biomed Mater Res A. 2016;104(12):2968-2977. 10.1002/ jbm.a.35845
32. Wei JL, Fu W, Ding YJ, et al. Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models. Arthritis Res Ther. 2017;19(1):280. 10.1186/s13075-017-1485-8
33. Chen L, Li Q, Wang J, et al. MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN. J Cell Mol Med. 2017;21(12):3347-3359. 10.1111/jcmm.13237
34. Wang J. Efficacy and safety of adalimumab by intra-articular injection for moderate to severe knee osteoarthritis: An open-label randomized controlled trial. J Int Med Res. 2018;46(1):326-334. 10.1177/0300060517723182
35. Dimitroulas T, Lambe T, Klocke R, Kitas GD, Duarte RV. Biologic drugs as analgesics for the management of osteoarthritis. Semin Arthritis Rheum. 2017;46(6):687-691. 10.1016/j.semarthrit.2016.12.001

APA	YILDIZ K, Boy F (2021). Serum progranulin to TNF-α ratio in patients with gonarthrosis. , 235 - 238. 10.5152/j.aott.2021.19249
Chicago	YILDIZ Kadri,Boy Fatih Serum progranulin to TNF-α ratio in patients with gonarthrosis. (2021): 235 - 238. 10.5152/j.aott.2021.19249
MLA	YILDIZ Kadri,Boy Fatih Serum progranulin to TNF-α ratio in patients with gonarthrosis. , 2021, ss.235 - 238. 10.5152/j.aott.2021.19249
AMA	YILDIZ K,Boy F Serum progranulin to TNF-α ratio in patients with gonarthrosis. . 2021; 235 - 238. 10.5152/j.aott.2021.19249
Vancouver	YILDIZ K,Boy F Serum progranulin to TNF-α ratio in patients with gonarthrosis. . 2021; 235 - 238. 10.5152/j.aott.2021.19249
IEEE	YILDIZ K,Boy F "Serum progranulin to TNF-α ratio in patients with gonarthrosis." , ss.235 - 238, 2021. 10.5152/j.aott.2021.19249
ISNAD	YILDIZ, Kadri - Boy, Fatih. "Serum progranulin to TNF-α ratio in patients with gonarthrosis". (2021), 235-238. https://doi.org/10.5152/j.aott.2021.19249

APA	YILDIZ K, Boy F (2021). Serum progranulin to TNF-α ratio in patients with gonarthrosis. Acta Orthopaedica et Traumatologica Turcica, 55(3), 235 - 238. 10.5152/j.aott.2021.19249
Chicago	YILDIZ Kadri,Boy Fatih Serum progranulin to TNF-α ratio in patients with gonarthrosis. Acta Orthopaedica et Traumatologica Turcica 55, no.3 (2021): 235 - 238. 10.5152/j.aott.2021.19249
MLA	YILDIZ Kadri,Boy Fatih Serum progranulin to TNF-α ratio in patients with gonarthrosis. Acta Orthopaedica et Traumatologica Turcica, vol.55, no.3, 2021, ss.235 - 238. 10.5152/j.aott.2021.19249
AMA	YILDIZ K,Boy F Serum progranulin to TNF-α ratio in patients with gonarthrosis. Acta Orthopaedica et Traumatologica Turcica. 2021; 55(3): 235 - 238. 10.5152/j.aott.2021.19249
Vancouver	YILDIZ K,Boy F Serum progranulin to TNF-α ratio in patients with gonarthrosis. Acta Orthopaedica et Traumatologica Turcica. 2021; 55(3): 235 - 238. 10.5152/j.aott.2021.19249
IEEE	YILDIZ K,Boy F "Serum progranulin to TNF-α ratio in patients with gonarthrosis." Acta Orthopaedica et Traumatologica Turcica, 55, ss.235 - 238, 2021. 10.5152/j.aott.2021.19249
ISNAD	YILDIZ, Kadri - Boy, Fatih. "Serum progranulin to TNF-α ratio in patients with gonarthrosis". Acta Orthopaedica et Traumatologica Turcica 55/3 (2021), 235-238. https://doi.org/10.5152/j.aott.2021.19249