Objective: In this study, we aimed to investigate the effectiveness of video-based exercise program on quality-of-life (QoL) domains.Material and Methods: A total of 68 participants, aged 18–35 years, were included in the study. The participants were divided into two groupson the basis of their willingness to exercise-the exercise group (n=39, 26.74±3.91 years, 28.2% men) and the control group (n=29, 27.59±2.82years, and 41.4% men). Both groups were evaluated with Rapid Assessment of Physical Activity and World Health Organization Quality of Life BREFthrough web-based forms, and the exercisers’ aerobic capacities were evaluated with a two-minute walk test (2MWT). The exercise group attended35 minutes of video-based exercise intervention three times a week for six weeks, whereas the control group continued their regular life. At theend of the study, the change in the general health status of the participants was rated with the Global Rating of Chance Scale (GRCS) and exercisesatisfaction with the 10-point Likert scale.Results: There were no differences in the QoL domains within or between the groups (P > .05) except within the group change in 2MWT totalwalking distance parameter in the exercise group (P < .001). However, GRCS scores were statistically higher in the exercise group (P < .001). Theoverall satisfaction with the video-based exercise program was 8.28±1.76 points.Conclusion: There was no significant increase in QoL domains with video-based exercises compared to the control group. However, these exercisesmay contribute to the preservation of aerobic capacity during periods when face-to-face exercises cannot be performed.