Hearing Assessment in Adult Patients with Common Variable Immunodeficiency

Arslan, Sevket; Arıcıgil, Mitat; Aytekin, Gökhan; YILDIZ, ERAY; ÇÖLKESEN, Fatih

doi:10.21911/aai.600

Hearing Assessment in Adult Patients with Common Variable Immunodeficiency

Gökhan AYTEKİN, (Konya Şehir Hastanesi, Alerji ve Klinik İmmünoloji Anabilim Dalı, Konya, Türkiye)

Fatih ÇÖLKESEN, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Alerji ve Klinik İmmünoloji Anabilim Dalı, Konya, Türkiye)

Eray YILDIZ, (Konya Şehir Hastanesi, Alerji ve Klinik İmmünoloji Anabilim Dalı, Konya, Türkiye)

Mitat ARICIGİL, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, Baş Boyun Cerrahisi, Konya, Türkiye)

Şevket ARSLAN (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Alerji ve Klinik İmmünoloji Anabilim Dalı, Konya, Türkiye)

Astım Allerji İmmünoloji

4 0

Yıl: 2021 Cilt: 19 Sayı: 1 Sayfa Aralığı: 38 - 45 Metin Dili: İngilizce DOI: 10.21911/aai.600 İndeks Tarihi: 05-10-2021

Hearing Assessment in Adult Patients with Common Variable Immunodeficiency

Öz:

Objective: Common Variable Immunodeficiency (CVID) is a primary antibody disorder characterized by impaired B cell differentiation.Patients commonly present with acute and chronic sinusitis as well as otitis media, which may lead to hearing loss.Materials and Methods: Thirty-three CVID patients (20 male /13 female) with a mean age of 35 years (range 19-65 years) and 33healthy individuals as a control group were included.Results: Among CVID patients, 17 (51.5%) had conductive hearing loss (CHL) , being unilateral in 4 (12.1%) and bilateral in 13 (39.4%).Unilateral and bilateral sensorineural hearing loss (SNHL) were detected in 2 (6.1%) and 5 (15.2%) respectively. CD4/CD8 cell ratio wassignificantly lower while CD8+ T lymphocyte ratio was significantly higher in those with CHL than in those without it (p=0.045 andp=0.009). Elevated CD8+ T cell ratio was an independent risk factor for CHL (p=0.015). Patients with SNHL were significantly olderthan those without it (p=0.040). CD16-56+ cell count was significantly lower in those with SNHL (p=0.031).Conclusion: CVID patients have an increased occurrence of CHL and SNHL, regardless of the cause. They provide evidence for thenotion that these two types of hearing loss are not unrelated, immune dysregulation also plays a role in the process, and SNHL is notindependent of CHL.

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APA	Aytekin G, ÇÖLKESEN F, YILDIZ E, Arıcıgil M, Arslan S (2021). Hearing Assessment in Adult Patients with Common Variable Immunodeficiency. , 38 - 45. 10.21911/aai.600
Chicago	Aytekin Gökhan,ÇÖLKESEN Fatih,YILDIZ ERAY,Arıcıgil Mitat,Arslan Sevket Hearing Assessment in Adult Patients with Common Variable Immunodeficiency. (2021): 38 - 45. 10.21911/aai.600
MLA	Aytekin Gökhan,ÇÖLKESEN Fatih,YILDIZ ERAY,Arıcıgil Mitat,Arslan Sevket Hearing Assessment in Adult Patients with Common Variable Immunodeficiency. , 2021, ss.38 - 45. 10.21911/aai.600
AMA	Aytekin G,ÇÖLKESEN F,YILDIZ E,Arıcıgil M,Arslan S Hearing Assessment in Adult Patients with Common Variable Immunodeficiency. . 2021; 38 - 45. 10.21911/aai.600
Vancouver	Aytekin G,ÇÖLKESEN F,YILDIZ E,Arıcıgil M,Arslan S Hearing Assessment in Adult Patients with Common Variable Immunodeficiency. . 2021; 38 - 45. 10.21911/aai.600
IEEE	Aytekin G,ÇÖLKESEN F,YILDIZ E,Arıcıgil M,Arslan S "Hearing Assessment in Adult Patients with Common Variable Immunodeficiency." , ss.38 - 45, 2021. 10.21911/aai.600
ISNAD	Aytekin, Gökhan vd. "Hearing Assessment in Adult Patients with Common Variable Immunodeficiency". (2021), 38-45. https://doi.org/10.21911/aai.600

APA	Aytekin G, ÇÖLKESEN F, YILDIZ E, Arıcıgil M, Arslan S (2021). Hearing Assessment in Adult Patients with Common Variable Immunodeficiency. Astım Allerji İmmünoloji, 19(1), 38 - 45. 10.21911/aai.600
Chicago	Aytekin Gökhan,ÇÖLKESEN Fatih,YILDIZ ERAY,Arıcıgil Mitat,Arslan Sevket Hearing Assessment in Adult Patients with Common Variable Immunodeficiency. Astım Allerji İmmünoloji 19, no.1 (2021): 38 - 45. 10.21911/aai.600
MLA	Aytekin Gökhan,ÇÖLKESEN Fatih,YILDIZ ERAY,Arıcıgil Mitat,Arslan Sevket Hearing Assessment in Adult Patients with Common Variable Immunodeficiency. Astım Allerji İmmünoloji, vol.19, no.1, 2021, ss.38 - 45. 10.21911/aai.600
AMA	Aytekin G,ÇÖLKESEN F,YILDIZ E,Arıcıgil M,Arslan S Hearing Assessment in Adult Patients with Common Variable Immunodeficiency. Astım Allerji İmmünoloji. 2021; 19(1): 38 - 45. 10.21911/aai.600
Vancouver	Aytekin G,ÇÖLKESEN F,YILDIZ E,Arıcıgil M,Arslan S Hearing Assessment in Adult Patients with Common Variable Immunodeficiency. Astım Allerji İmmünoloji. 2021; 19(1): 38 - 45. 10.21911/aai.600
IEEE	Aytekin G,ÇÖLKESEN F,YILDIZ E,Arıcıgil M,Arslan S "Hearing Assessment in Adult Patients with Common Variable Immunodeficiency." Astım Allerji İmmünoloji, 19, ss.38 - 45, 2021. 10.21911/aai.600
ISNAD	Aytekin, Gökhan vd. "Hearing Assessment in Adult Patients with Common Variable Immunodeficiency". Astım Allerji İmmünoloji 19/1 (2021), 38-45. https://doi.org/10.21911/aai.600