Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism

Yıl: 2021 Cilt: 22 Sayı: 1 Sayfa Aralığı: 24 - 30 Metin Dili: İngilizce DOI: 10.5152/TurkThoracJ.2021.190076 İndeks Tarihi: 06-10-2021

Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism

Öz:
OBJECTIVE: Pulmonary embolism (PE) is a serious pathology with high rates of morbidity and mortality. Studies regarding the efficacy of new inflammatory markers as a predictor of mortality in PE have thus far been limited. This study aimed to evaluate the predictive value of platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), platelet/mean platelet volume (PLT/MPV), and C-reactive protein (CRP) on short-term and long-term mortality in patients with PE.MATERIAL AND METHODS: A retrospective, observational cohort study was carried out in a tertiary teaching hospital. Patients with PE hospitalized in the pulmonology ward were enrolled. Their characteristics, hemogram parameters, PLR, NLR, CRP levels, PLT/MPV on admission, and mortality were recorded. The predictive accuracies of inflammatory markers were determined through receiver operating characteristic curves. The risk factors for mortality were further analyzed with Cox regression analysis.RESULTS: A total of 828 patients with PE were included in the study. The 1-month mortality was 1%, and the 1-year mortality was 8.5%. An NLR value above 6 was associated with an almost 13-fold increase in short-term (30-day) mortality. We found that an NLR above 3.15 and age were independent risk factors for long-term (1-year) mortality. The other inflammatory markers, namely PLR and CRP, were not found to be associated with long-term mortality.CONCLUSION: PE is a serious condition in the elderly. Elevated NLR values appear to be a good and feasible predictor of inflammation, which can be correlated with higher mortality over both the short-term and long-term periods.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Ma Y, Mao Y, He X, et al. The values of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting 30 day mortality in patients with acute pulmonary embolism. BMC Cardiovasc Disord 2016;16:123. doi: 10.1186/s12872-016-0304-5. [Crossref]
  • 2. Özsu SS, Gürel Durmuş Z, Coşkuner MB, et al. Does the incidence and mortality of pulmonary thromboembolism change over the years? Turk Thorac J 2017;18:78-81. [Crossref]
  • 3. Yazıcı S, Kırış T, Ceylan US, et al. The accuracy of combined use of troponin and red cell distribution width in predicting mortality of patients with acute pulmonary embolism. Wien Klin Wochenschr 2016;128 (Suppl 8):596-603. doi: 10.1007/ s00508-016-1081-y. Epub 2016 Sep 19. [Crossref]
  • 4. Zhou XY, Chen HL, Ni SS. Red cell distribution width in predicting 30-day mortality in patients with pulmonary embolism. J Crit Care 2017;37:197-01. doi: 10.1016/j.jcrc.2016.09.024. Epub 2016 Oct 6. [Crossref]
  • 5. Akgüllü Ç, Ömürlü İK, Eryılmaz U, et al. Predictors of early death in patients with acute pulmonary embolism. Am J Emerg Med 2015;33:214-21. [Crossref]
  • 6. Çavuş UY, Yıldırım S, Sönmez E, et al. Prognostic value of neutrophil/lymphocyte ratio in patients with pulmonary embolism. Turk J Med Sci 2014;44:50-5. [Crossref]
  • 7. Karatas MB, Ipek G, Onuk T, et al. Assessment of Prognostic Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Patients with Pulmonary Embolism. Acta Cardiol Sin 2016;32:313-20.
  • 8. Ozcan Cetin EH, Cetin MS, Canpolat U, et al. Platelet-to-lymphocyte ratio as a novel marker of in-hospital and long-term adverse outcomes among patients with acute pulmonary embolism. A single center large-scale study. Thromb Res 2017;150:33-40. [Crossref]
  • 9. Alotaibi GS, Wu C, Senthilselvan A, McMurty MS. Secular Trends in Incidence and Mortality of Acute Venous Thromboembolism: The AB-VTE Population-Based Study. Am J Med 2016;129:879e19-25. [Crossref]
  • 10. Wang Q, Ma JU, Jiang Z, Ming L. Prognostic value of neutrophilto-lymphocyte ratio and platelet-to-lymphocyte ratio in acute pulmonary embolism: A systemic review and meta-analysis. Int Angiol 2018;37:4-11.
  • 11. Li W, Liu Q, Tang Y. Platelet to lymphocyte ratio in the prediction of adverse outcomes after acute coronary syndrome: A meta-analysis Sci Rep 2017;7:40426. doi: 10.1038/srep40426. [Crossref]
  • 12. Kurtipek E, Bekci TT, Kesli R, et al. The role of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in exacerbation of chronic obstructive pulmonary disease. J Pak Med Assoc 2015;65:1283-7.
  • 13. Jagadesham VP, Lagarde SM, Immanuel A, Griffin SM. Systemic inflammatory markers and outcome in patients with locally advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction. Br J Surg 2017;104:401-7. doi: 10.1002/ bjs.10425. [Crossref]
  • 14. Duman D, Aksoy E, Coban Agca M, et al. The utility of inflammatory markers to predict readmissions and mortality in COPD cases with or without eosinophilia. Int J Chron Obstruct Pulmon Dis 2015;10:2469-78. doi: 10.2147/COPD.S90330. Erratum in: Int J Chron Obstruct Pulmon Dis 2016;11:417. [Crossref]
  • 15. Soylu K, Gedikli Ö, Ekşi A, et al. Neutrophil-to-lymphocyte ratio for the assessment of hospital mortality in patients with acute pulmonary embolism. Arch Med Sci 2016;12:95-100. [Crossref]
  • 16. Kayrak M, Erdogan HI, Solak Y, et al. Prognostic value of neutrophil to lymphocyte ratio in patients with acute pulmonary embolism: a retrospective study. Heart Lung Circ 2014;23:56- 62. [Crossref]
  • 17. Kundi H, Balun A, Cicekcioglu H, et al. The relation between platelet-to-lymphocyte ratio and Pulmonary embolism severity index in acute pulmonary embolism. Heart Lung 2015;44:340- 3. [Crossref]
  • 18. Günay E, Ulaslı SS, Kacar E, et al. Can platelet indices predict obstruction level of pulmonary vascular bed in patients with acute pulmonary embolism? Clin Respir J 2014;8:33-40. [Crossref]
  • 19. Sunnetçioğlu A, Karadaş S. Mean platelet volume as an indicator of disease in patients with acute pulmonary embolisms. East J Med 2014;19:107-11.
  • 20. Abul Y, Karakurt S, Ozben B, et al. T. C-reactive protein in acute pulmonary embolism. J Invest Med 2011;59:8-14. [Crossref]
  • 21. Friz P, Corno V, Orenti A, et al. Comorbidity assessment as predictor of short and long term mortality in elderly patients with hemodynamically stable acute pulmonary embolism. J Thromb Thrombolysis 2017;44:316-23. [Crossref]
  • 22. Jo JY, Lee MY, Lee JW, et al. Leukocytes and systemic inflammatory response syndrome as prognostic factors in pulmonary embolism patients. BMC Pulm Med 2013;13:74. [Crossref]
APA duman d, Sonkaya E, YILDIRIM E, GIDIK E, Tanülkü U, Salturk C, Karakurt Z (2021). Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism. , 24 - 30. 10.5152/TurkThoracJ.2021.190076
Chicago duman dildar,Sonkaya Esin,YILDIRIM Elif,GIDIK Erman,Tanülkü Uğurcan,Salturk Cuneyt,Karakurt Zuhal Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism. (2021): 24 - 30. 10.5152/TurkThoracJ.2021.190076
MLA duman dildar,Sonkaya Esin,YILDIRIM Elif,GIDIK Erman,Tanülkü Uğurcan,Salturk Cuneyt,Karakurt Zuhal Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism. , 2021, ss.24 - 30. 10.5152/TurkThoracJ.2021.190076
AMA duman d,Sonkaya E,YILDIRIM E,GIDIK E,Tanülkü U,Salturk C,Karakurt Z Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism. . 2021; 24 - 30. 10.5152/TurkThoracJ.2021.190076
Vancouver duman d,Sonkaya E,YILDIRIM E,GIDIK E,Tanülkü U,Salturk C,Karakurt Z Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism. . 2021; 24 - 30. 10.5152/TurkThoracJ.2021.190076
IEEE duman d,Sonkaya E,YILDIRIM E,GIDIK E,Tanülkü U,Salturk C,Karakurt Z "Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism." , ss.24 - 30, 2021. 10.5152/TurkThoracJ.2021.190076
ISNAD duman, dildar vd. "Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism". (2021), 24-30. https://doi.org/10.5152/TurkThoracJ.2021.190076
APA duman d, Sonkaya E, YILDIRIM E, GIDIK E, Tanülkü U, Salturk C, Karakurt Z (2021). Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism. Turkish Thoracic Journal, 22(1), 24 - 30. 10.5152/TurkThoracJ.2021.190076
Chicago duman dildar,Sonkaya Esin,YILDIRIM Elif,GIDIK Erman,Tanülkü Uğurcan,Salturk Cuneyt,Karakurt Zuhal Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism. Turkish Thoracic Journal 22, no.1 (2021): 24 - 30. 10.5152/TurkThoracJ.2021.190076
MLA duman dildar,Sonkaya Esin,YILDIRIM Elif,GIDIK Erman,Tanülkü Uğurcan,Salturk Cuneyt,Karakurt Zuhal Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism. Turkish Thoracic Journal, vol.22, no.1, 2021, ss.24 - 30. 10.5152/TurkThoracJ.2021.190076
AMA duman d,Sonkaya E,YILDIRIM E,GIDIK E,Tanülkü U,Salturk C,Karakurt Z Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism. Turkish Thoracic Journal. 2021; 22(1): 24 - 30. 10.5152/TurkThoracJ.2021.190076
Vancouver duman d,Sonkaya E,YILDIRIM E,GIDIK E,Tanülkü U,Salturk C,Karakurt Z Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism. Turkish Thoracic Journal. 2021; 22(1): 24 - 30. 10.5152/TurkThoracJ.2021.190076
IEEE duman d,Sonkaya E,YILDIRIM E,GIDIK E,Tanülkü U,Salturk C,Karakurt Z "Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism." Turkish Thoracic Journal, 22, ss.24 - 30, 2021. 10.5152/TurkThoracJ.2021.190076
ISNAD duman, dildar vd. "Association of Inflammatory Markers with Mortalityin Patients Hospitalized with Non-massive PulmonaryEmbolism". Turkish Thoracic Journal 22/1 (2021), 24-30. https://doi.org/10.5152/TurkThoracJ.2021.190076