(All India Institute of Medical Sciences (AIIMS), Department of Rheumatology, India)
(All India Institute of Medical Sciences (AIIMS), Department of Rheumatology, India)
(All India Institute of Medical Sciences (AIIMS), Department of Cardiac Biochemistry, India)
(All India Institute of Medical Sciences (AIIMS), Department of Rheumatology, India)
Yıl: 2021Cilt: 8Sayı: 2ISSN: 2147-9720 / 2148-4279Sayfa Aralığı: 79 - 83İngilizce

21 0
Prevalence of pre-clinical autoimmunity in the normal adult population residing in a metropolitan city of India: A cross-sectional study
Objective: A steep rise in the incidence of autoimmune diseases over the decades has been observed,which is simply not explainable with population-level genetic changes, indicating thereby that environmental factors play an important role in their causation. Then again, how air pollution affectsthe immune system is still not completely elucidated. This study intends to check the presence ofautoantibodies and inflammatory markers in normal adults residing for more than 10 years in a highlypolluted region.Methods: In this observational cross-sectional study design, 1,500 subjects residing in Delhi, India, formore than 10 years were screened, of whom 500 were recruited for the study. Distance from the mainroad to an individual’s house was calculated, which was taken as a proxy for traffic pollution exposure.These subjects were analyzed for autoantibodies and inflammatory markers.Results: The mean age of our cohort was 31.0±8.3 years. Autoantibody positivity was observed in 18%of the subjects, whereas inflammatory markers were elevated in 68% of the subjects. Subjects residingwithin 200 m of the main road had a higher prevalence of autoantibodies antinuclear antibody (12.5%vs 6.5% p=0.03) and rheumatoid factor (9.6% vs 4.5% p=0.02) than the subjects residing at or morethan 250 m away from the main road.Conclusion: A total of 18% of normal subjects had autoantibody positivity. The odds of developing antinuclear antibodies were twice higher in subjects who resided within 200 m of the main road wherethe exposure to pollution was higher.
DergiAraştırma MakalesiErişime Açık
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