Uma KUMAR
(All India Institute of Medical Sciences (AIIMS), Department of Rheumatology, India)
Maumita KANJILAL
(All India Institute of Medical Sciences (AIIMS), Department of Rheumatology, India)
Lakshmy RAMAKRISHNAN
(All India Institute of Medical Sciences (AIIMS), Department of Cardiac Biochemistry, India)
Maheswari THANGAVELU
(All India Institute of Medical Sciences (AIIMS), Department of Rheumatology, India)
Yıl: 2021Cilt: 8Sayı: 2ISSN: 2147-9720 / 2148-4279Sayfa Aralığı: 79 - 83İngilizce

21 0
Prevalence of pre-clinical autoimmunity in the normal adult population residing in a metropolitan city of India: A cross-sectional study
Objective: A steep rise in the incidence of autoimmune diseases over the decades has been observed,which is simply not explainable with population-level genetic changes, indicating thereby that environmental factors play an important role in their causation. Then again, how air pollution affectsthe immune system is still not completely elucidated. This study intends to check the presence ofautoantibodies and inflammatory markers in normal adults residing for more than 10 years in a highlypolluted region.Methods: In this observational cross-sectional study design, 1,500 subjects residing in Delhi, India, formore than 10 years were screened, of whom 500 were recruited for the study. Distance from the mainroad to an individual’s house was calculated, which was taken as a proxy for traffic pollution exposure.These subjects were analyzed for autoantibodies and inflammatory markers.Results: The mean age of our cohort was 31.0±8.3 years. Autoantibody positivity was observed in 18%of the subjects, whereas inflammatory markers were elevated in 68% of the subjects. Subjects residingwithin 200 m of the main road had a higher prevalence of autoantibodies antinuclear antibody (12.5%vs 6.5% p=0.03) and rheumatoid factor (9.6% vs 4.5% p=0.02) than the subjects residing at or morethan 250 m away from the main road.Conclusion: A total of 18% of normal subjects had autoantibody positivity. The odds of developing antinuclear antibodies were twice higher in subjects who resided within 200 m of the main road wherethe exposure to pollution was higher.
DergiAraştırma MakalesiErişime Açık
  • 1. Adams DD, Knight JG, Ebringer A. Autoimmune diseases: Solution of the environmental, immunological and genetic components with principles for immunotherapy and transplantation. Autoimmun Rev 2010; 9: 525-30.
  • 2. Kivity S, Agmon-Levin N, Blank M, Shoenfeld Y. Infections and autoimmunity - friends or foes?. Trends Immunol 2009; 30: 409-14.
  • 3. Brook RD, Franklin B, Cascio W, Hong Y, Howard G, Lipsett M, et al. Air pollution and cardiovascular disease. Circulation 2004; 109: 2655-71.
  • 4. Pope CA, Dockery DW. Health effects of fine particulate air pollution: Lines that connect. J Air Waste Manage Assoc 2006; 56: 709-42.
  • 5. Bairwa M, Rajput M, Sachdeva S. Modified Kuppuswamy's socioeconomic scale: Social researcher should include updated income criteria, 2012. Indian J Community Med 2013; 38: 185-6.
  • 6. Li Q-Z, Karp DR, Quan J, Branch VK, Zhou J, Lian Y, et al. Risk factors for ANA positivity in healthy persons. Arthritis Res Ther 2011; 13: R38.
  • 7. Government of India, Ministry of Road Transport and Highways, Transport Research Wing. Basic Road Statistics of India 2013-14 and 2014- 15. New Delhi; 2016. Available from: https:// morth.nic.in/sites/default/files/Basic_Road_ Statistics_of_India_2013_14_and_2014_15.pdf
  • 8. Hart JE, Laden F, Puett RC, Costenbader KH, Karlson EW. Exposure to traffic pollution and increased risk of rheumatoid arthritis. Environ Health Perspect 2009; 117: 1065-9.
  • 9. Hart JE, Källberg H, Laden F, Bellander T, Costenbader KH, Holmqvist M, et al. Ambient air pollution exposures and risk of rheumatoid arthritis: Results from the Swedish EIRA case-control study. Ann Rheum Dis 2013; 72: 888-94.
  • 10. Fernandez SAV, Lobo AZC, de Oliveira ZNP, Fukumori LMI, Périgo AM, Rivitti EA. Prevalence of antinuclear autoantibodies in the serum of normal blood donors. Rev Hosp Clin Fac Med Sao Paulo 2003; 58: 315-9.
  • 11. Semchuk KM, Rosenberg AM, McDuffie HH, Cessna AJ, Pahwa P, Irvine DG. Antinuclear antibodies and bromoxynil exposure in a rural sample. J Toxicol Environ Heal Part A 2007; 70: 638-57.
  • 12. Hayashi N, Koshiba M, Nishimura K, Sugiyama D, Nakamura T, Morinobu S, et al. Prevalence of disease-specific antinuclear antibodies in general population: Estimates from annual physical examinations of residents of a small town over a 5-year period. Mod Rheumatol 2008; 18: 153- 60.
  • 13. Satoh M, Chan EKL, Ho LA, Rose KM, Parks CG, Cohn RD, et al. Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis Rheum 2012; 64: 2319-27.
  • 14. Atabonkeng EP. Evaluation of the prevalence of rheumatoid factor in five regions of Cameroon. Arch Rheumatol 2015; 30: 226-30.
  • 15. Simard JF, Holmqvist M. Rheumatoid factor positivity in the general population. BMJ 2012; 345: e5841.
  • 16. Örge E, Çefle A, Yazıcı A, Gürel-Polat N, Hulagu S. The positivity of rheumatoid factor and anti-cyclic citrullinated peptide antibody in nonarthritic patients with chronic hepatitis c infection. Rheumatol Int 2010; 30: 485-8.
  • 17. Thompson AMS, Zanobetti A, Silverman F, Schwartz J, Coull B, Urch B, et al. Baseline repeated measures from controlled human exposure studies: associations between ambient air pollution exposure and the systemic inflammatory biomarkers IL-6 and fibrinogen. Environ Health Perspect 2010; 118: 120-4.
  • 18. Panasevich S, Leander K, Rosenlund M, Ljungman P, Bellander T, de Faire U, et al. Associations of long- and short-term air pollution exposure with markers of inflammation and coagulation in a population sample. Occup Environ Med 2009; 66: 747-53.
  • 19. Calderón-Garcidueñas L, Villarreal-Calderon R, Valencia-Salazar G, Henríquez-Roldán C, Gutiérrez-Castrellón P, Torres-Jardón R, et al. Systemic inflammation, endothelial dysfunction, and activation in clinically healthy children exposed to air pollutants. Inhal Toxicol 2008; 20: 499-506.
  • 20. Calderón-Garcidueñas L, Macías-Parra M, Hoffmann HJ, Valencia-Salazar G, Henríquez-Roldán C, Osnaya N, et al. Immunotoxicity and environment: Immunodysregulation and systemic inflammation in children. Toxicol Pathol 2009; 37: 161-9.
  • 21. Eriksson C, Kokkonen H, Johansson M, Hallmans G, Wadell G, Rantapää-Dahlqvist S. Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden. Arthritis Res Ther 2011; 13: R30.
  • 22. Rantapää-Dahlqvist S, de Jong BAW, Berglin E, Hallmans G, Wadell G, Stenlund H, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 2003; 48: 2741-9.

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