Yıl: 2021 Cilt: 6 Sayı: 2 Sayfa Aralığı: 251 - 261 Metin Dili: İngilizce DOI: 10.26453/otjhs.876015 İndeks Tarihi: 29-07-2022

The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19

Öz:
Objective: To investigate neutrophil/lymphocyte (NLR), lymphocyte/monocyte (LMR), platelet/lymphocyte (PLR) ratios, and the value of these parameters in determining disease severity and progression in hospitalized COVID-19 patients.Materials and Methods: Study was conducted retrospectively with 182 in-patients and 91 controls due to COVID-19 between April-September 2020 in the chest diseases clinic. Hematological parameters and rates were compared with controls’ parameters. Correlations and differences between hematological parameters and other parameters were investigated.Results: Lymphocyte, monocyte, eosinophil, basophil, hemoglobin, thrombocyte, and LMR were significantly lower. NLR and PLR were higher. There were significant increases in hematological parameters and PLR on discharge. A positive correlation existed between radiological pneumonia severity score, and NLR (r=0.234, p=0.001) and PLR (r=0.128, p=0.042), and significant inverse correlation with LMR (r=-0.206, p=0.003). Positive correlations were detected between NLR (r=0.140, p=0.030) and PLR (r=0.125, p=0.046), and symptom-discharge time, and inverse correlation between LMR, and both symptom-discharge (r=-0.137, p=0.032) and hospital stay time (r=-0.135, p=0.034). A positive correlation existed between CRP, and NLR and PLR on admission and discharge. Conclusion: NLR, LMR and PLR were found as hematological predictors to be used with CRP in following-up COVID-19, showing a significant correlation with disease severity, monitoring responses to treatment and predicting prognosis.
Anahtar Kelime: COVID-19 lymphocyte monocyte ratio neutrophil lymphocyte ratio radiological pneumonia severity score platelet lymphocyte ratio

COVID-19’lu Yatan Hastalarda Nötrofil/Lenfosit Oranı, Lenfosit/Monosit Oranı, Platelet/Lenfosit Oranı ve Hematolojik Parametrelerin Hastalığın Şiddet ve Prognozu ile İlişkisi

Öz:
Amaç: Hastanede yatan COVID-19’lu hastalarda nötrofil/lenfosit oranı (NLR), lenfosit/monosit oranı (LMR), platelet/lenfosit oranı (PLR) ve hematolojik parametrelerin hastalığın şiddeti ve prognozunu belirlemedeki değerini araştırmaktır. Materyal ve Metot: Çalışma bir göğüs hastalıkları kliniğinde Nisan-Eylül 2020 tarihleri arasında COVID-19 nedeniyle yatan 182 hasta ve 91 kontrol grubu ile retrospektif olarak gerçekleştirildi. Takipte hematolojik parametreler ile diğer parametreler arasındaki ilişki ve farklılıklar araştırıldı. Bulgular: Lenfosit, monosit, eozinofil, bazofil, hemoglobin, trombosit ve LMR anlamlı olarak daha düşüktü. NLR ve PLR daha yüksekti. Taburcu aşamasında, hematolojik parametreler ve PLR’de anlamlı artış bulundu. Radyolojik pnömoni şiddet skoru ile NLR (r=0.234, p=0.001) ve PLR (r=0.128, p=0.042) arasında anlamlı pozitif korelasyon ve LMR ile anlamlı ters korelasyon (r=-0.206, p=0.003) vardı. NLR (r=0.140, p=0.030) ve PLR (r=0.125, p=0.046) ile semptom-taburcu süresi arasında pozitif yönlü, LMR ile hem semptom-taburcu (r=-0.137, p=0.032) hem de hastanede kalış süresi (r=-0.135, p=0.034) arasında ters yönlü korelasyon tespit edildi. Hastaneye kabul ve taburculukta CRP ile NLR ve PLR arasında da pozitif bir korelasyon vardı. Sonuç: NLR, LMR ve PLR, COVİD-19’lu hastalarda hastalığın takibinde CRP’yle birlikte kullanılabilecek, hastalığın şiddetiyle anlamlı korelasyon gösteren, tedaviye yanıtı izlemede ve prognozu öngörmede faydalanılabilecek hematolojik prediktörler olarak bulunmuştur.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Korkmaz C, Demirbas S, vatansev h, Yosunkaya Ş, TEKE T, Zamani A, Poyraz N, Yilmaz P, Uyar M (2021). The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19. , 251 - 261. 10.26453/otjhs.876015
Chicago Korkmaz Celalettin,Demirbas Soner,vatansev hülya,Yosunkaya Şebnem,TEKE TURGUT,Zamani Adil,Poyraz Necdet,Yilmaz Pinar Diydem,Uyar Mehmet The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19. (2021): 251 - 261. 10.26453/otjhs.876015
MLA Korkmaz Celalettin,Demirbas Soner,vatansev hülya,Yosunkaya Şebnem,TEKE TURGUT,Zamani Adil,Poyraz Necdet,Yilmaz Pinar Diydem,Uyar Mehmet The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19. , 2021, ss.251 - 261. 10.26453/otjhs.876015
AMA Korkmaz C,Demirbas S,vatansev h,Yosunkaya Ş,TEKE T,Zamani A,Poyraz N,Yilmaz P,Uyar M The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19. . 2021; 251 - 261. 10.26453/otjhs.876015
Vancouver Korkmaz C,Demirbas S,vatansev h,Yosunkaya Ş,TEKE T,Zamani A,Poyraz N,Yilmaz P,Uyar M The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19. . 2021; 251 - 261. 10.26453/otjhs.876015
IEEE Korkmaz C,Demirbas S,vatansev h,Yosunkaya Ş,TEKE T,Zamani A,Poyraz N,Yilmaz P,Uyar M "The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19." , ss.251 - 261, 2021. 10.26453/otjhs.876015
ISNAD Korkmaz, Celalettin vd. "The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19". (2021), 251-261. https://doi.org/10.26453/otjhs.876015
APA Korkmaz C, Demirbas S, vatansev h, Yosunkaya Ş, TEKE T, Zamani A, Poyraz N, Yilmaz P, Uyar M (2021). The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19. Online Türk Sağlık Bilimleri Dergisi, 6(2), 251 - 261. 10.26453/otjhs.876015
Chicago Korkmaz Celalettin,Demirbas Soner,vatansev hülya,Yosunkaya Şebnem,TEKE TURGUT,Zamani Adil,Poyraz Necdet,Yilmaz Pinar Diydem,Uyar Mehmet The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19. Online Türk Sağlık Bilimleri Dergisi 6, no.2 (2021): 251 - 261. 10.26453/otjhs.876015
MLA Korkmaz Celalettin,Demirbas Soner,vatansev hülya,Yosunkaya Şebnem,TEKE TURGUT,Zamani Adil,Poyraz Necdet,Yilmaz Pinar Diydem,Uyar Mehmet The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19. Online Türk Sağlık Bilimleri Dergisi, vol.6, no.2, 2021, ss.251 - 261. 10.26453/otjhs.876015
AMA Korkmaz C,Demirbas S,vatansev h,Yosunkaya Ş,TEKE T,Zamani A,Poyraz N,Yilmaz P,Uyar M The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19. Online Türk Sağlık Bilimleri Dergisi. 2021; 6(2): 251 - 261. 10.26453/otjhs.876015
Vancouver Korkmaz C,Demirbas S,vatansev h,Yosunkaya Ş,TEKE T,Zamani A,Poyraz N,Yilmaz P,Uyar M The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19. Online Türk Sağlık Bilimleri Dergisi. 2021; 6(2): 251 - 261. 10.26453/otjhs.876015
IEEE Korkmaz C,Demirbas S,vatansev h,Yosunkaya Ş,TEKE T,Zamani A,Poyraz N,Yilmaz P,Uyar M "The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19." Online Türk Sağlık Bilimleri Dergisi, 6, ss.251 - 261, 2021. 10.26453/otjhs.876015
ISNAD Korkmaz, Celalettin vd. "The Association of Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, Platelet/Lymphocyte Ratio and Hematological Parameters with Severity and Prognosis in Hospitalized Patients with COVID-19". Online Türk Sağlık Bilimleri Dergisi 6/2 (2021), 251-261. https://doi.org/10.26453/otjhs.876015