This study aims to examine the compliance of school administrations with the Improving Hygiene Conditions in MoNE Educational Institutions and the Infection Prevention Control Guide during the Covid-19 pandemic process. A descriptive survey model was used in the study. The study sample consists of 4414 school administrators and teachers in seven different regions of Turkey in 2021. In the research, "personal information form" and "Hygiene Control Scale" using the Self-Assessment Question List of the Infection Prevention and Control Guidelines for Improving Hygiene Conditions in Educational Institutions and Infection Prevention Control Guide as data collection tool in the study. As a result of the analyses made, it was found that the school administrators' compliance with the Improving Hygiene Conditions in the MoNE Educational Institutions and the Infection Prevention Control Guide was much higher according to managers and high according to teachers. Teachers and administrators who have received hygiene training perceive the level of compliance with the guide higher. The level of compliance of school administrators with the guide differs significantly according to the geographical region and settlement where the school is located. The level of compliance with the guide by school administrators in the Eastern Anatolia and Southeastern Anatolia Regions are lower than school administrations in Marmara, Mediterranean, Aegean, Black Sea, and Central Anatolia regions the level of compliance with the guideline. The level of compliance with the guide by school administrations in the city and central district is higher than the level of compliance with the guide by school administrations in towns and districts. The level of compliance with the guide by school administrations in metropolitan cities is higher than the level of compliance with the guide of school administrations in villages and districts. The research findings were discussed, suggestions were made for decision-makers, practitioners, and researchers.