Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study

SAHİN, Yusuf; TEKE, Hacer Yasar; ERDEM, Havva

doi:10.4274/haseki.galenos.2021.7174

Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study

Havva Erdem, (Ordu Üniversitesi Tıp Fakültesi, Tıbbi Patoloji Anabilim Dalı, Ordu, Türkiye)

Hacer Yasar Teke, (Ordu Üniversitesi Tıp Fakültesi, Adli Tıp Anabilim Dalı, Ordu, Türkiye)

Yusuf Sahin (Adli Tıp Müdürlüğü, Adli Tıp, Ordu, Türkiye)

Haseki Tıp Bülteni

5 0

Yıl: 2021 Cilt: 59 Sayı: 4 Sayfa Aralığı: 280 - 285 Metin Dili: İngilizce DOI: 10.4274/haseki.galenos.2021.7174 İndeks Tarihi: 04-11-2021

Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study

Öz:

Aim: It is known that muscle mass decreases with age. Sometimes it may be possible to adversely affect this reduction. It was aimedto investigate the contribution of claudin-5 and E-cadherin to this process.Methods: Samples were taken from the psoas muscle of 55 cases autopsied for different reasons between 2018-2019. Age, gender,weight, height, chronic disease, and addiction were recorded. Histopathological degeneration parameters were evaluated. In addition,samples were prepared for immunohistochemical study. Evaluation for E-cadherin and claudin-5; no staining, weak staining, moderatestaining and severe staining. Fibrosis was evaluated with Masson trichrome.Results: There was a very strong and statistically significant inverse relationship between acidophilic sarcoplasma and staining withclaudin-5 (p<0.01). There was also a strong positive correlation between cellular fatty cell degeneration status and staining withclaudin-5 (p=0.04). No correlation could be established between sociodemographic characteristics of the cases and staining withclaudin-5 and E-cadherin, nor could there be a correlation between staining with E-cadherin and staining with claudin-5 (p>0.05).Conclusion: Claudin-5 can be a target protein that can be used in the detection and prophylaxis of degeneration and atrophy instriated muscles.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ERDEM H, TEKE H, SAHİN Y (2021). Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study. , 280 - 285. 10.4274/haseki.galenos.2021.7174
Chicago	ERDEM Havva,TEKE Hacer Yasar,SAHİN Yusuf Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study. (2021): 280 - 285. 10.4274/haseki.galenos.2021.7174
MLA	ERDEM Havva,TEKE Hacer Yasar,SAHİN Yusuf Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study. , 2021, ss.280 - 285. 10.4274/haseki.galenos.2021.7174
AMA	ERDEM H,TEKE H,SAHİN Y Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study. . 2021; 280 - 285. 10.4274/haseki.galenos.2021.7174
Vancouver	ERDEM H,TEKE H,SAHİN Y Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study. . 2021; 280 - 285. 10.4274/haseki.galenos.2021.7174
IEEE	ERDEM H,TEKE H,SAHİN Y "Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study." , ss.280 - 285, 2021. 10.4274/haseki.galenos.2021.7174
ISNAD	ERDEM, Havva vd. "Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study". (2021), 280-285. https://doi.org/10.4274/haseki.galenos.2021.7174

APA	ERDEM H, TEKE H, SAHİN Y (2021). Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study. Haseki Tıp Bülteni, 59(4), 280 - 285. 10.4274/haseki.galenos.2021.7174
Chicago	ERDEM Havva,TEKE Hacer Yasar,SAHİN Yusuf Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study. Haseki Tıp Bülteni 59, no.4 (2021): 280 - 285. 10.4274/haseki.galenos.2021.7174
MLA	ERDEM Havva,TEKE Hacer Yasar,SAHİN Yusuf Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study. Haseki Tıp Bülteni, vol.59, no.4, 2021, ss.280 - 285. 10.4274/haseki.galenos.2021.7174
AMA	ERDEM H,TEKE H,SAHİN Y Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study. Haseki Tıp Bülteni. 2021; 59(4): 280 - 285. 10.4274/haseki.galenos.2021.7174
Vancouver	ERDEM H,TEKE H,SAHİN Y Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study. Haseki Tıp Bülteni. 2021; 59(4): 280 - 285. 10.4274/haseki.galenos.2021.7174
IEEE	ERDEM H,TEKE H,SAHİN Y "Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study." Haseki Tıp Bülteni, 59, ss.280 - 285, 2021. 10.4274/haseki.galenos.2021.7174
ISNAD	ERDEM, Havva vd. "Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study". Haseki Tıp Bülteni 59/4 (2021), 280-285. https://doi.org/10.4274/haseki.galenos.2021.7174