Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome

cakmak, bulent; CİHAN, Esra; CİHAN, Ahmet

doi:10.4274/jus.galenos.2020.4028

Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome

Ahmet Cihan, (Niğde Eğitim ve Araştırma Hastanesi, Üroloji Kliniği, Niğde, Türkiye)

Esra Cihan, (Niğde Ömer Halisdemir Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı, Niğde, Türkiye)

Bülent Çakmak (Niğde Ömer Halisdemir Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı, Niğde, Türkiye)

Journal of Urological Surgery

4 0

Yıl: 2021 Cilt: 8 Sayı: 2 Sayfa Aralığı: 98 - 105 Metin Dili: İngilizce DOI: 10.4274/jus.galenos.2020.4028 İndeks Tarihi: 21-10-2021

Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome

Öz:

Objective: The clinical relevance of low urine pH and perceived stress levels in patients with bladder pain syndrome (BPS) has not yet been clarified.In this study, we hypothesised that urine pH and perceived stress levels may differ in patients with BPS and that they may be related to each other.Materials and Methods: A prospective case-control study was conducted to test the hypothesis. Patients aged >18 years who were newly diagnosedwith BPS were included in the patient group. The control group consisted of healthy volunteers aged >18 years. The 10-item Perceived Stress scale(PSS-10), spot urine pH measurements, Interstitial Cystitis Symptom index (ICSI), Interstitial Cystitis Problem index (ICPI), visual analogue scale forpain (VAS-Pain) and quality-of-life (QOL) scores were evaluated. Independent samples t-test and multivariate regression with path analysis wereperformed.Results: The study evaluated 84 patients with BPS and 86 healthy participants. The mean spot urine pH, PSS-10, ICSI, ICPI, VAS-Pain and QOL scoreswere different between the patient group and control group. Spot urine pH level [p=0.01, odds ratio (OR)=0.31] and PSS-10 scores (p=0.01, OR=1.1)remained significant predictors of BPS in the multivariate analysis. Lower urine pH and higher perceived stress levels were associated with worseICSI, ICPI, VAS-Pain and QOL scores.Conclusion: Acidic urine pH and high perceived stress levels are associated with the presence of BPS. Perceived stress is independent from low urinepH, as they each relate to BPS symptoms in a bidirectional manner.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Hanno P, Nordling J, Fall M. Bladder pain syndrome. Med Clin North Am 2011;95:55-73.
2. Sönmez MG, Göğer YE, Ecer G, Atıcı A, Özkent MS, Öztürk A. Effects of urine alkalinization with sodium bicarbonate orally on lower urinary tract symptoms in female patients: a pilot study. Int Urogynecol J 2018;29:1029- 1033.
3. Ueda T, Yoshida T, Tanoue H, Ito M, Tamaki M, Ito Y, Yoshimura N. Urine alkalization improves the problems of pain and sleep in hypersensitive bladder syndrome. Int J Urol 2014;21:512-517.
4. Remer T. Influence of nutrition on acid-base balance--metabolic aspects. Eur J Nutr 2001;40:214-220.
5. Esche J, Shi L, Sánchez-Guijo A, Hartmann MF, Wudy SA, Remer T. Higher diet-dependent renal acid load associates with higher glucocorticoid secretion and potentially bioactive free glucocorticoids in healthy children. Kidney Int 2016;90:325-333.
6. Rothrock NE, Lutgendorf SK, Kreder KJ, Ratliff T, Zimmerman B. Stress and symptoms in patients with interstitial cystitis: a life stress model. Urology 2001;57:422-427.
7. Lutgendorf SK, Kreder KJ, Rothrock NE, Ratliff TL, Zimmerman B. A laboratory stress model for examining stress and symptomatology in interstitial cystitis patients. Urology 2001;57(6 Suppl 1):122.
8. Hanna-Mitchell AT, Wolf-Johnston A, Roppolo JR, Buffington TC, Birder LA. Corticotropin-releasing factor family peptide signaling in feline bladder urothelial cells. J Endocrinol 2014;222:113-121.
9. Hanno PM, Erickson D, Moldwin R, Faraday MM; American Urological Association. Diagnosis and treatment of interstitial cystitis/bladder pain syndrome: AUA guideline amendment. J Urol 2015;193:1545-1553.
10. Doggweiler R, Whitmore KE, Meijlink JM, Drake MJ, Frawley H, Nordling J, Hanno P, Fraser MO, Homma Y, Garrido G, Gomes MJ, Elneil S, van de Merwe JP, Lin ATL, Tomoe H. A standard for terminology in chronic pelvic pain syndromes: A report from the chronic pelvic pain working group of the international continence society. Neurourol Urodyn 2017;36:984-1008.
11. O’Leary MP, Sant GR, Fowler FJ Jr, Whitmore KE, Spolarich-Kroll J. The interstitial cystitis symptom index and problem index. Urology 1997;49(5A Suppl):58-63.
12. Lubeck DP, Whitmore K, Sant GR, Alvarez-Horine S, Lai C. Psychometric validation of the O’leary-Sant interstitial cystitis symptom index in a clinical trial of pentosan polysulfate sodium. Urology 2001;57(6 Suppl 1):62-66.
13. Eskin M, Harlak H, Demirkıran F, Dereboy Ç. Algılanan Stres Ölçeğinin Türkçeye Uyarlanması: Güvenirlik ve Geçerlik Analizi. Yeni Symp J 2013;51:132-140.
14. Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav 1983;24:385-396.
15. Kaya C, Tansey TN, Melekoglu M, Cakiroglu O, Chan F. Psychometric evaluation of Turkish version of the Perceived Stress Scale with Turkish college students. J Ment Health 2019;28:161-167.
16. Whitmore KE, Fall M, Sengiku A, Tomoe H, Logadottir Y, Kim YH. Hunner lesion versus non-Hunner lesion interstitial cystitis/bladder pain syndrome. Int J Urol 2019;26 Suppl 1:26-34.
17. Akiyama Y, Hanno P. Phenotyping of interstitial cystitis/bladder pain syndrome. Int J Urol. 2019;26 Suppl 1:17-19.
18. Acar Ö, Tarcan T. Cystoscopic evaluation and clinical phenotyping in interstitial cystitis/bladder pain syndrome. J Turk Ger Gynecol Assoc 2019;20:117-122.
19. Sorokin I, Mamoulakis C, Miyazawa K, Rodgers A, Talati J, Lotan Y. Epidemiology of stone disease across the world. World J Urol 2017;35:1301- 1320.
20. Nguan C, Franciosi LG, Butterfield NN, Macleod BA, Jens M, Fenster HN. A prospective, double-blind, randomized cross-over study evaluating changes in urinary pH for relieving the symptoms of interstitial cystitis. BJU Int 2005;95:91-94.
21. Sánchez-Freire V, Blanchard MG, Burkhard FC, Kessler TM, Kellenberger S, Monastyrskaya K. Acid-sensing channels in human bladder: expression, function and alterations during bladder pain syndrome. J Urol 2011;186:1509-1516.
22. Holzer P, Izzo AA. The pharmacology of TRP channels. Br J Pharmacol 2014;171:2469-2473.
23. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997;389:816-824.
24. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 1998;21:531-543.
25. Jordt SE, Tominaga M, Julius D. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci U S A 2000;97:8134-8139.
26. Matos R, Serrão P, Rodriguez L, Birder LA, Cruz F, Charrua A. The water avoidance stress induces bladder pain due to a prolonged alpha1A adrenoceptor stimulation. Naunyn Schmiedebergs Arch Pharmacol 2017;390:839-844.
27. Lutgendorf SK, Kreder KJ, Rothrock NE, Ratliff TL, Zimmerman B. Stress and symptomatology in patients with interstitial cystitis: a laboratory stress model. J Urol 2000;164:1265-1269.
28. Mullins C, Bavendam T, Kirkali Z, Kusek JW. Novel research approaches for interstitial cystitis/bladder pain syndrome: thinking beyond the bladder. Transl Androl Urol 2015;4:524-533.
29. Jhang JF, Birder LA, Jiang YH, Hsu YH, Ho HC, Kuo HC. Dysregulation of bladder corticotropin-releasing hormone receptor in the pathogenesis of human interstitial cystitis/bladder pain syndrome. Sci Rep 2019;9:19169.

APA	CİHAN A, CİHAN E, cakmak b (2021). Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome. , 98 - 105. 10.4274/jus.galenos.2020.4028
Chicago	CİHAN Ahmet,CİHAN Esra,cakmak bulent Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome. (2021): 98 - 105. 10.4274/jus.galenos.2020.4028
MLA	CİHAN Ahmet,CİHAN Esra,cakmak bulent Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome. , 2021, ss.98 - 105. 10.4274/jus.galenos.2020.4028
AMA	CİHAN A,CİHAN E,cakmak b Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome. . 2021; 98 - 105. 10.4274/jus.galenos.2020.4028
Vancouver	CİHAN A,CİHAN E,cakmak b Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome. . 2021; 98 - 105. 10.4274/jus.galenos.2020.4028
IEEE	CİHAN A,CİHAN E,cakmak b "Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome." , ss.98 - 105, 2021. 10.4274/jus.galenos.2020.4028
ISNAD	CİHAN, Ahmet vd. "Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome". (2021), 98-105. https://doi.org/10.4274/jus.galenos.2020.4028

APA	CİHAN A, CİHAN E, cakmak b (2021). Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome. Journal of Urological Surgery, 8(2), 98 - 105. 10.4274/jus.galenos.2020.4028
Chicago	CİHAN Ahmet,CİHAN Esra,cakmak bulent Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome. Journal of Urological Surgery 8, no.2 (2021): 98 - 105. 10.4274/jus.galenos.2020.4028
MLA	CİHAN Ahmet,CİHAN Esra,cakmak bulent Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome. Journal of Urological Surgery, vol.8, no.2, 2021, ss.98 - 105. 10.4274/jus.galenos.2020.4028
AMA	CİHAN A,CİHAN E,cakmak b Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome. Journal of Urological Surgery. 2021; 8(2): 98 - 105. 10.4274/jus.galenos.2020.4028
Vancouver	CİHAN A,CİHAN E,cakmak b Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome. Journal of Urological Surgery. 2021; 8(2): 98 - 105. 10.4274/jus.galenos.2020.4028
IEEE	CİHAN A,CİHAN E,cakmak b "Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome." Journal of Urological Surgery, 8, ss.98 - 105, 2021. 10.4274/jus.galenos.2020.4028
ISNAD	CİHAN, Ahmet vd. "Perceived Stress and Accompanying Low Urine pH Are in Relation to Bladder Pain Syndrome". Journal of Urological Surgery 8/2 (2021), 98-105. https://doi.org/10.4274/jus.galenos.2020.4028