Yıl: 2004 Cilt: 67 Sayı: 2 Sayfa Aralığı: 92 - 98 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables

Öz:
In this study, two proliferation markers; i.e. thymidine labeling index (TLI) and Ki-67 scores of 32 breast cancer patients were evaluated by assessing the relationship with other prognostic parameters including lymph node status, nuclear-histopathologic grades, tumor size, estrogen-progesterone status and menopausal status. Both TLI values and Kİ67 scores were correlated with nuclear and histologic grades. While indices of both proliferation markers were significantly lower in estrogen receptor positive patients than hormone negative patients, only TLI values were found to be significantly lower in progesterone receptor positive patients. No other correlations or associations between variables reached statistical significance. In conclusion, TLI and Ki-67 scores may be independent prognostic factors as nuclear grade and hormonal status.
Anahtar Kelime: Cell Proliferation Thymidine Staining and Labeling Breast Neoplasms Ki-67 Antigen

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Quinn MC, Wright AN. The clinical assessment of proliferation and growth in human tumours: Evaluation of methods and applications as prognostic variables. J Pathol 1990; 160:93.
  • 2. Scott RJ, Hall A, Haldane JS et al. Comparison of immunohistochemical markers of cell proliferation with experimentally determined growth fraction. J Pathol 1991; 165:173.
  • 3. Amadori D and Silvestrini R. Prognostic and predictive value of thymidine labelling index in breast cancer. Breast Cancer Res Treat 1998; 51: 267.
  • 4. Burger PC, Shibata T, Kleihues P. The use of the monoclonal antibody Ki-67 in the identification of proliferating cells: Application to surgical neuropathology. Am J Sur Pathol 1986; 10: 611.
  • 5. Brown DC, Gatter KC. Monoclonal antibody Ki-67: its use in histopathology. Histopathology 1990; 17: 489.
  • 6. Midulla C, Cenci M, De Iorio P et al. DNA ploidy and TLI in association with other prognostic parameters in breast cancer. Anticancer Res 1999; 19: 381.
  • 7. Barnard NJ, Hall PA, Lemoine NR, Kadar N. Proliferative index in breast carcinomas determined in-situ by Ki-67 immunostaining and its relationship to clinical and pathological variables. J Pathol 1987; 152: 287.
  • 8. Hasebe T, Mukai K, Tsuda H, Ochiai A. New prognostic histological parameter of invasive ductal carcinoma of the breast: clinicopathological significance of fibrotic focus. Pathol Int 2000; 50: 263.
  • 9. Fisher ER, Redmond C, Fisher B. Histologic grading of breast cancer. Pathol Annu 1980; 15: 239.
  • 10. Black MM, Speer FD, Nuclear structure in cancer tissues. Surg Gynecol Obstet 1957; 105: 97.
  • 11. Daidone MG and Silvestrini R. Prognostic and predictive role of proliferation indices in adjuvant therapy of breast cancer. J Natl Cancer Inst Monographs 2001; 2001: 27.
  • 12. Del Bino G, Silvestrini R, Costa A, S et al. Morphological and clinical significance of cell kinetics in non-Hodgkin’s lymphomas. Basic Appl Histochem 1986; 30:197.
  • 13. Akerman M, Brandt L, Johnson A, Olsson H. Mitotic activity in non-Hodgkin's lymphoma. Relation to the Kiel classification and to prognosis. Br J Cancer 1987; 55: 219.
  • 14. Ozmen V, Cabioglu N, Dolay K et al. Biological considerations in locally advanced breast cancer treated with anthracycline-based neoadjuvant chemotherapy: thymidine labelling index is an independent indicator of clinical outcome. Breast Cancer Res Treat 2001; 68: 147.
  • 15. Pronzato P, Queirolo P, Vecchio S et al. Thymidine labeling index analysis in early breast cancer patients randomized to receive perioperative chemotherapy. Oncology 2001; 60: 88.
  • 16. Araki K, Kimura M, Sakamoto K, Nishimura R, and Akagi Ml. Significance of the tritiated thymidine labeling index in breast cancer. Jpn J Surg 15: 144-9 (1985).
  • 17. Hall PA. Rewiew: Assessment of cell proliferation in histological material. J Clin Pathol 1990; 43: 184-92.
  • 18. Gerdes J, Li L, Schlueter C et al. Immunobiochemical and molecular biologic characterization of the cell proliferation associated nuclear antigen that is defined by monoclonal antibody Ki-67. Am J Pathol 1991; 138: 867.
  • 19. Wolberg WH, Street WN, Mangasarian OL. Importance of nuclear morphology in breast cancer prognosis. Clin Cancer Res 1999; 5: 3542 .
  • 20. Pienta KJ and Coffey DS. Correlation of nuclear morphometry with progression of breast cancer. Cancer 1991; 68: 2012 .
  • 21. McGurrin JF, Doria MI Jr, Dawson PJ et al. Assessment of tumor cell kinetics by immunohistochemistry in carcinoma of breast. Cancer 1987; 59: 1744.
  • 22. Yang Q, Mori I, Sakurai T, Yoshimura G et al. Correlation between nuclear grade and biological prognostic variables in invasive breast cancer. Breast Cancer 2001; 8: 105.
  • 23. Gerdes J, Lelle RJ, Pickartz H et al. Growth fraction in breast cancers determined in situ with monoclonal antibody Ki-67. J Clin Pathol 1986; 39: 977.
  • 24. Raymond WA, Leong AS-Y. The relationship between growth fractions and oestrogen receptors in human breast carcinoma, as determined by immunohistochemical staining. J Pathol 1989; 158: 203.
  • 25. Correale M, Abbate I, Paradiso A et al. pS2- a new cytosolic protein recognized by monoclonal antibodies as a marker of hormone sensitivity in breast cancer. Cell Biophysics 1993; 22: 101.
  • 26. Pichon MF, Pallud C, Brunet M, Milgrom E. Relationship of presence of progesterone receptors to prognosis in early breast cancer. Cancer Res 1980; 40: 3357.
  • 27. Cattoretti G, Rilke F, Andreola S et al. P53 expression in breast cancer. Int J Cancer 1988; 48: 4368.
  • 28. Wrba F, Reiner A, Markis-Ritzinger E et al. Prognostic significance of immunohistochemical parameters in breast carcinomas. Pathol Res Pract. 1988; 183: 277 .
  • 29. Gebauer G, Fehm T, Lang N, Jöger W. Tumor size, axillary lymph node status and steroid receptor expression in breast cancer: prognostic relevance 5 years after surgery. Breast Cancer Res Treat 2002; 75:167.
  • 30. Silvestrini R, Daidone MG, Luisi A et al. Cell proliferation in 3,800 node-negative breast cancers: consistency over time of biological and clinical information provided by 3H-thymidine labeling index. Int J Cancer 1997; 74: 122.
  • 31. Meyer JS, Province MA. S-phase fraction and nuclear size in long term prognosis of patients with breast cancer. Cancer 1994; 74: 2287 .
  • 32. Sigurdsson H, Baldetorp B, Borg A et al. Indicators of prognosis in node-negative breast cancer. N Engl J Med 1990; 322: 1045.
  • 33. Rudolph P, Alm P, Heidebrecht HJ et al. Immunologic proliferation marker Ki-S2 as prognostic indicator for lymph node-negative breast cancer. J Natl Cancer Inst 1999; 91: 271.
  • 34. Kroman N, Jensen MB, Wohlfahrt J et al. Factors influencing the effect of age on prognosis in breast cancer: population based study. Commentary: much still to learn about relations between tumour biology, prognosis, and treatment outcome in early breast cancer. BMJ 2000; 320: 474.
  • 35. Veronese SM, Gambacorta M, Gottardi O et al. Proliferation index as a prognostic marker in breast cancer. Cancer 1993; 71: 3926 .
APA KOYUTURK M, AHISHALI B, Yavuz E, BİLİR A (2004). Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables. , 92 - 98.
Chicago KOYUTURK Meral,AHISHALI Bülent,Yavuz Ekrem,BİLİR Ayhan Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables. (2004): 92 - 98.
MLA KOYUTURK Meral,AHISHALI Bülent,Yavuz Ekrem,BİLİR Ayhan Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables. , 2004, ss.92 - 98.
AMA KOYUTURK M,AHISHALI B,Yavuz E,BİLİR A Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables. . 2004; 92 - 98.
Vancouver KOYUTURK M,AHISHALI B,Yavuz E,BİLİR A Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables. . 2004; 92 - 98.
IEEE KOYUTURK M,AHISHALI B,Yavuz E,BİLİR A "Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables." , ss.92 - 98, 2004.
ISNAD KOYUTURK, Meral vd. "Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables". (2004), 92-98.
APA KOYUTURK M, AHISHALI B, Yavuz E, BİLİR A (2004). Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables. İstanbul Üniversitesi İstanbul Tıp Fakültesi Mecmuası, 67(2), 92 - 98.
Chicago KOYUTURK Meral,AHISHALI Bülent,Yavuz Ekrem,BİLİR Ayhan Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables. İstanbul Üniversitesi İstanbul Tıp Fakültesi Mecmuası 67, no.2 (2004): 92 - 98.
MLA KOYUTURK Meral,AHISHALI Bülent,Yavuz Ekrem,BİLİR Ayhan Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables. İstanbul Üniversitesi İstanbul Tıp Fakültesi Mecmuası, vol.67, no.2, 2004, ss.92 - 98.
AMA KOYUTURK M,AHISHALI B,Yavuz E,BİLİR A Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables. İstanbul Üniversitesi İstanbul Tıp Fakültesi Mecmuası. 2004; 67(2): 92 - 98.
Vancouver KOYUTURK M,AHISHALI B,Yavuz E,BİLİR A Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables. İstanbul Üniversitesi İstanbul Tıp Fakültesi Mecmuası. 2004; 67(2): 92 - 98.
IEEE KOYUTURK M,AHISHALI B,Yavuz E,BİLİR A "Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables." İstanbul Üniversitesi İstanbul Tıp Fakültesi Mecmuası, 67, ss.92 - 98, 2004.
ISNAD KOYUTURK, Meral vd. "Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables". İstanbul Üniversitesi İstanbul Tıp Fakültesi Mecmuası 67/2 (2004), 92-98.