Introduction: To examine the indications for termination dueto fetal anomalies performed in our clinic between January2015 and October 2020 and to determine the differencesbetween years.Methods: This study is a retrospective, observational studyinvolving 385 patients who underwent termination beforethe 24th week due to fetal anomalies at Karadeniz TechnicalUniversity, Farabi Hospital, Clinic of Perinatology. Terminationdata were analyzed by dividing the sample into two groups:terminations performed between 11 and 14 weeks (firsttrimester) and those between 15 and 24 weeks (secondtrimester) of gestation.Results: Structural malformations constituted 81.3% oftermination of pregnancy (TOP) cases, chromosomalanomalies 14.5%, and genetic diseases 4.2%. Central nervoussystem (CNS) anomalies, at 43.4%, were the most commoncause of termination. Aneuploidy was present in 56 (34.8%)of 161 cases for which karyotype analysis was available. Thenumber of terminations that took place in both the first andthe second trimesters was the highest in 2019. A continuousincrease was observed in the number of terminations overthe years evaluated. When the systems were evaluatedindividually, it was observed that the number of cases in thesecond trimester with CNS and face and neck anomalies wasstatistically significantly higher than that in the first trimester(p=0.002, p=0.037, respectively). In all, 28.3% of terminationswere performed in the first trimester and 71.7% in the secondtrimester.Conclusion: When the distribution of TOP indications over theyears was examined, it was observed that the number of casesrelated to chromosomal anomalies, cardiovascular systemanomalies, and genetic diseases had increased gradually.