MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ
Yıl: 2020 Cilt: 27 Sayı: 2 Sayfa Aralığı: 160 - 165 Metin Dili: Türkçe DOI: 10.17343/sdutfd.605500 İndeks Tarihi: 10-11-2021
MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ
Öz: AmaçMeme kanserinde, moleküler alt tiplerin, klinikopatolojiközellikler (tanı yaşı, histolojik tip, histolojik derece,pT ve pN evreleri) ile ilişkilerinin tespit edilmesiamaçlanmıştır.Gereç ve YöntemÇalışma grubu 194 kadın meme kanseri içermekteydi.Süleyman Demirel Üniversitesi Tıp Fakültesi TıbbiPatoloji Anabilim Dalı arşivi taranarak 2010-2015 yıllarıarasında meme kanseri tanısı verilmiş olgulara aitbiyopsi ve radikal meme rezeksiyonu materyallerininpreparatları tekrar incelendi. Olguların immünhistokimyasalER, PgR, HER2 ve Ki67 boyalı preparatlarıtekrar değerlendirilerek moleküler alt tiplendirme yapıldı.BulgularTümör moleküler alt tipleri; %47,4 olguda Luminal A[ER ve/veya PgR(+)/HER2(-)/Ki67 ≤ %14], %25,8 olgudaLuminal B [ER ve/veya PgR(+)/HER2(+) veya(-) /Ki67 > %14], %13,4 olguda HER2 overeksprese[ER(-)/PgR(-)/HER2(+)] ve %13,4 olguda ise üçlünegatif [ER(-)/PgR(-)/HER2(-)] idi. Tümör derecesive aksiller lenf nodu metastazı; Luminal B, HER2overeksprese ve üçlü negatif tümörlerde Luminal Atümörlere göre daha yüksek izlendi. Luminal tip tümörlerlekarşılaştırıldığında, HER2 overeksprese veüçlü negatif tümörlerde lenfovasküler invazyon oranıanlamlı olarak daha fazla idi.SonuçHeterojen bir tümör grubu olan meme kanserlerindeevre ve diğer iyi bilinen klinikopatolojik özelliklerin yanındamoleküler alt tiplendirmenin de hasta yönetimiiçin faydalı bilgiler verebileceği sonucuna varılmıştır.
Anahtar Kelime: THE RELATIONSHIP OF THE MOLECULAR SUBTYPES WITH THE CLINICOPATHOLOGICAL FEATURES IN BREAST CANCER
Öz: Objective To determine the relationship between the molecular subtypes and the clinicalopathological features (age at the diagnosis, histological type, histological grade, pT and pN stages) in breast cancer. Materials and Methods The study population included 194 women with breast carcinoma, who were diagnosed between 2010 and 2015. The slides of the cases in the archive of the Süleyman Demirel University Faculty of Medicine Department of Pathology were reevaluated. Immunohis-tochemical ER, PgR, HER2 and Ki67 stained slides were used to perform the molecular subtyping. Results Among the cases molecular subtypes were; Luminal A [ER and/or PgR(+)/HER2(-)/Ki67 ≤ 14%] in 47.4% of cases, Luminal B [ER and/or PgR(+)/HER2(+) or (-) /Ki67 > 14%] in 25.8% of cases, HER2 overexpressing [ER(-)/PgR(-)/HER2(+)] in 13.4% of cases, and triple negative [ER(-)/PgR(-)/HER2(-)] in 13.4% of the cases, respectively. Tumor grade and axillary lymph node metastasis in Luminal B, HER2 overexpressing and triple negative tumors were significantly higher than they were in Luminal A tumors. Lymphovascular invasion rate was significantly higher in HER2 overexpressing and triple negative tumors compared to Luminal type tumors. Conclusions It was concluded that the molecular subtyping of the breast carcinoma, which is a heterogeneous tumor group, can give important information for the management of the cases along with the stage and other well-known clinicopathological features.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | BOZKURT K, çiriş m, durak Ö, Kapucuoglu F, Devrim T (2020). MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ. , 160 - 165. 10.17343/sdutfd.605500 |
| Chicago | BOZKURT KEMAL KÜRŞAT,çiriş metin,durak Özlem,Kapucuoglu Fatma Nilgün,Devrim Tuba MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ. (2020): 160 - 165. 10.17343/sdutfd.605500 |
| MLA | BOZKURT KEMAL KÜRŞAT,çiriş metin,durak Özlem,Kapucuoglu Fatma Nilgün,Devrim Tuba MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ. , 2020, ss.160 - 165. 10.17343/sdutfd.605500 |
| AMA | BOZKURT K,çiriş m,durak Ö,Kapucuoglu F,Devrim T MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ. . 2020; 160 - 165. 10.17343/sdutfd.605500 |
| Vancouver | BOZKURT K,çiriş m,durak Ö,Kapucuoglu F,Devrim T MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ. . 2020; 160 - 165. 10.17343/sdutfd.605500 |
| IEEE | BOZKURT K,çiriş m,durak Ö,Kapucuoglu F,Devrim T "MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ." , ss.160 - 165, 2020. 10.17343/sdutfd.605500 |
| ISNAD | BOZKURT, KEMAL KÜRŞAT vd. "MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ". (2020), 160-165. https://doi.org/10.17343/sdutfd.605500 |
| APA | BOZKURT K, çiriş m, durak Ö, Kapucuoglu F, Devrim T (2020). MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 27(2), 160 - 165. 10.17343/sdutfd.605500 |
| Chicago | BOZKURT KEMAL KÜRŞAT,çiriş metin,durak Özlem,Kapucuoglu Fatma Nilgün,Devrim Tuba MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 27, no.2 (2020): 160 - 165. 10.17343/sdutfd.605500 |
| MLA | BOZKURT KEMAL KÜRŞAT,çiriş metin,durak Özlem,Kapucuoglu Fatma Nilgün,Devrim Tuba MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, vol.27, no.2, 2020, ss.160 - 165. 10.17343/sdutfd.605500 |
| AMA | BOZKURT K,çiriş m,durak Ö,Kapucuoglu F,Devrim T MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi. 2020; 27(2): 160 - 165. 10.17343/sdutfd.605500 |
| Vancouver | BOZKURT K,çiriş m,durak Ö,Kapucuoglu F,Devrim T MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi. 2020; 27(2): 160 - 165. 10.17343/sdutfd.605500 |
| IEEE | BOZKURT K,çiriş m,durak Ö,Kapucuoglu F,Devrim T "MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ." Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 27, ss.160 - 165, 2020. 10.17343/sdutfd.605500 |
| ISNAD | BOZKURT, KEMAL KÜRŞAT vd. "MEME KANSERİNDE MOLEKÜLER ALT TİPLERİN KLİNİKOPATOLOJİK ÖZELLİKLERLE İLİŞKİSİ". Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 27/2 (2020), 160-165. https://doi.org/10.17343/sdutfd.605500 |
