Yıl: 2020 Cilt: 9 Sayı: 4 Sayfa Aralığı: 225 - 232 Metin Dili: İngilizce DOI: 10.33880/ejfm.2020090405 İndeks Tarihi: 12-11-2021

Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours

Öz:
Aim: The aim of this study is to determine the rates of rapid antigen detection test use, test results and its relationship with Modified Centor Score and investigate the effect of rapid antigen detection test use on prescribing behaviour.Methods: This research was conducted by scanning the family physicians¶ information system retrospectively. From the Family Medicine Information System, where polyclinics and prescription records of the family health centers where 12 family physicians work in Kayseri are located, the number and results of rapid antigen detection tests performed between February 2017 and April 2019, the Modified Centor Score automatically calculated by the system, the number of prescribed antibiotics and symptomatic treatment information was recorded.Results: The positivity of rapid antigen detection test was considered, cut-off value of Modified Centor Score was >2 (ROC EAA:63.9, Cl:0.95,0.61-0.66). Sensitivity rate of the test for diagnostic score was 86% and selectivity rate was 48.8%.Conclusion: Family physicians should be encouraged to use rapid antigen detection test. The fact that antibiotics are prescribed in rapid antigen detection test negative patients may indicate that confidence level of the test is less than physical examination and clinical findings.
Anahtar Kelime:

Aile Hekimlerinin Hızlı Antijen Testi Kullanım Oranları, Test Sonuçları ve Reçetelendirmeye Etkisi

Öz:
Amaç: Bu çalışmanın amacı, hızlı antijen testi kullanım oranlarını, test sonuçlarını, Modifiye Centor Skoru ile ilişkisini belirlemek ve hızlı antijen testi kullanımının reçete yazma davranışı üzerindeki etkisini araştırmaktır. Yöntem: Bu araştırma Aile Hekimliği Bilgi Sistemi retrospektif taranarak yapılmıştır. Kayseri'de 12 aile hekiminin çalıştığı aile sağlığı merkezinin poliklinik ve reçete kayıtlarının yer aldığı Aile Hekimliği Bilgi Sistemi'nden, 2017 Şubat ile 2019 Nisan ayları arasında yapılan hızlı antijen testi testi sayısı ve sonuçları, sistem tarafından otomatik hesaplanan Modifiye Centor Skorları, reçetelenen antibiyotik sayıları ve semptomatik tedavi bilgileri kaydedildi. Bulgular: Hızlı antijen testi pozitifliği dikkate alınarak bakıldığında Modifiye Centor Skoru cut- off değeri >2 idi (ROC EAA:63,9, Cl:0,95,0,61-0,66). Tanı puanı için testin duyarlılığı %86, seçiciliği %48,8'dir. Sonuç: Aile hekimleri tarafından hızlı antijen testi kullanımı teşvik edilmelidir. Hızlı antijen testi negatif hastalarda da antibiyotik reçete ediliyor olması teste olan güvenin fizik muayeneye ve klinik bulgulara olan güvenden daha az olduğunun bir göstergesi olabilir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık
  • 1. Tanz RR, Gerber MA, Kabat W, Rippe J, Seshadri R, Shulman ST. Performance of a rapid antigen-detection test and throat culture in community pediatric offices: Implications for management of pharyngitis. Pediatrics 2009;123:437–44. doi: 10.1542/peds.2008-0488.
  • 2. Gerber MA. Comparison of throat cultures and rapid strep tests for diagnosis of streptococcal pharyngitis. Pediatr Infect Dis J 1989;8(11):820-4. doi: 10.1097/00006454-198911000-00032.
  • 3. Lieu TA, Fleisher GR, Schwartz JS. Clinical evaluation of a latex agglutination test for streptococcal pharyngitis: performance and impact on treatment rates. Pediatr Infect Dis J 1988;7(12):847-54.
  • 4. Hashigucci K, Matsunobu T. Etiology of acute pharyngitis in adults: the presence of viruses and bacteria. Nippon Jibiinkoka Gakkai Kaiho 2003;106:532–9. doi: 10.3950/jibiinkoka.106.532.
  • 5. Centor RM, Witherspoon JM, Dalton HP, Brody CE, Link K. The diagnosis of strep throat in adults in the emergency room. Med Decis Mak 1981;1(3):239-46. doi: 10.1177/0272989X8100100304.
  • 6. Pelucchi C, Grigoryan L, Galeone C, Esposito S, Huovinen P, Little P, et al. Guideline for the management of acute sore throat. Clin Microbiol Infect 2012;18:1–27. doi: 10.1111/j.1469-0691.2012.03766.x.
  • 7. Gözüküçük R, Göçmen İ, Nas Y, Yılmazer F, Ünüvar E. Streptokoksik tonsillofarenjit tanısında Strep-A hızlı testinin etkinliği. Çocuk Derg 2011;11(4):157-9. doi.org/10.5222/j.child.2011.157.
  • 8. Choby BA. Diagnosis and treatment of streptococcal pharyngitis. Am Fam Physician 2009;79:383–90. doi: 10.1001/jama.254.7.907.
  • 9. Shulman ST, Bisno AL, Clegg HW, Gerber MA, Kaplan EL, Lee G, et al. Clinical practice guideline for the diagnosis and management of group a streptococcal pharyngitis: 2012 update by the infectious diseases society of America. Clin Infect Dis 2012;55:86–102. doi: 10.1093/cid/cis629.
  • 10. Bisno AL, Peter GS, Kaplan EL. Diagnosis of strep throat in adults: are clinical criteria really good enough? Clin Infect Dis 2002;35:126–9. doi: 10.1086/342056.
  • 11. Gonzales R, Camargo CA, MacKenzie T, Kersey AS, Maselli J, Levin SK, et al. Antibiotic treatment of acute respiratory infections in acute care settings. Acad Emerg Med 2006;13:288–94. doi: 10.1197/j.aem.2005.10.016.
  • 12. Linder JA, Bates DW, Lee GM, Finkelstein JA. Antibiotic treatment of children with sore throat. J Am Med Assoc 2005;294:2315–22. doi: 10.1001/jama.294.18.2315.
  • 13. Portier H, Peyramond D, Boucot I, Grappin M, Boibieux A, Pribil C, et al. Assessing applicability of Cots JM. Impact on antibiotic prescription of rapid antigen detection testing in acute pharyngitis in adults: A randomised clinical trial. Br J Gen Pract 2011;61:244–51. doi: 10.3399/bjgp11X572436.
  • 14. Pulcini C, Pauvif L, Paraponaris A, Verger P, Ventelou B. Perceptions and attitudes of French general practitioners towards rapid antigen diagnostic tests in acute pharyngitis using a randomized case vignette study. J Antimicrob Chemother 2012;67:1540–6. doi: 10.1093/jac/dks073.
  • 15. Topkaya AE, Uysal S, Johansson CB. Boğaz sürüntü örneklerinde antijen tarama testi ile kültürün karşılaştırılması. Flora 2003;8(4):287–90.
  • 16. Cabbarpur C, Büyüklü F, Çakmak Ö, Haşimoğlu R, Ergin F, Özhan Rz, et al. Akut tonsillofarenjitte rapid strep A testi kullanımı. KBB- Forum 2004;3(1):10–2.
  • 17. Worrall G, Hutchinson J, Sherman G, Griffiths J. Diagnosing streptococcal sore throat in adults: Randomized controlled trial of in-office aids. Can Fam Physician 2007;53(4):666–71.
  • 18. Llor C, Madurell J, Balagué- Corbella M, Gómez M, Cots JM. Impact on antibiotic prescription of rapid antigen detection testing in acute pharyngitis in adults: A randomised clinical trial. Br J Gen Pract 2011;61:244–51. doi: 10.3399/bjgp11X572436.
  • 19. Mistik S, Gokahmetoglu S, Balci E, Onuk FA. Sore throat in primary care project: a clinical score to diagnose viral sore throat. Fam Pract 2015;32:263–8. doi: 10.1093/fampra/cmv015.
  • 20. McIsaac WJ, Goel V, Slaughter PM, Parsons GW, Woolnough K V, Weir PT, et al. Reconsidering sore throats - part 2: alternative approach and practical office tool. Can Fam Physician 1997;43:495–500. PMID: 9116521.
  • 21. McIsaac WJ, Goel V, To T, Low DE. The validity of a sore throat score in family practice. Cmaj 2000;163(7):811–5.
  • 22. McIsaac WJ, Kellner JD, Aufricht P, Vanjaka A, Low DE. Empirical validation of guidelines for the management of pharyngitis in children and adults. J Am Med Assoc 2004;291:1587–95. doi: 10.1001/jama.291.13.1587.
  • 23. Kose E, Kose SS, Akca D, Yildiz K, Elmas C, Baris M, et al. The effect of rapid antigen detection test on antibiotic prescription decision of clinicians and reducing antibiotic costs in children with acute pharyngitis. J Trop Pediatr 2016;62:308–15. doi: 10.1093/tropej/fmw014.
  • 24. Pontin IPO, Sanchez DCJ, Di Francesco R. Asymptomatic Group A Streptococcus carriage in children with recurrent tonsillitis and tonsillar hypertrophy. Int J Pediatr Otorhinolaryngol 2016;86:57–9. doi: 10.1016/j.ijporl.2016.03.044.
  • 25. Tiwari P, Ahlawat R, Gupta G. Prescription practice in patients of upper respiratory tract infection at a pediatric outpatient clinic in Punjab. Indian J Pharm Pract 2014;7:26–32. doi: 10.5530/ijopp.7.2.6.
  • 26. Torvi JR, Dambal S. Drug prescription pattern in paediatric out patient clinic in a tertiary hospital. Curr Pediatr Res 2011;15(2):77–80.
  • 27. Le Marechal F, Martinot A, Duhamel A, Pruvost I, Dubos F. Streptococcal pharyngitis in children: A meta-analysis of clinical decision rules and their clinical variables. BMJ Open 2013;3:e001482. doi: 10.1136/bmjopen-2012-001482.
  • 28. Das B, Sarkar C, Majumder AG. Medication use for pediatric upper respiratory tract infections. Fundam Clin Pharmacol 2006;20:385–90. doi: 10.1111/j.1472-8206.2006.00414.x.
  • 29. Sullivan JE, Farrar HC. Fever and antipyretic use in children. Pediatrics 2011;127(3):580–7. doi: 10.1542/peds.2010-3852.
APA Aslaner H, Aslaner H, ERTURK ARIK B, Onuk A, Benli A, Mistik S (2020). Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours. , 225 - 232. 10.33880/ejfm.2020090405
Chicago Aslaner Hümeyra,Aslaner Hacı Ahmet,ERTURK ARIK BADE,Onuk Alpay,Benli Ali Ramazan,Mistik Selcuk Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours. (2020): 225 - 232. 10.33880/ejfm.2020090405
MLA Aslaner Hümeyra,Aslaner Hacı Ahmet,ERTURK ARIK BADE,Onuk Alpay,Benli Ali Ramazan,Mistik Selcuk Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours. , 2020, ss.225 - 232. 10.33880/ejfm.2020090405
AMA Aslaner H,Aslaner H,ERTURK ARIK B,Onuk A,Benli A,Mistik S Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours. . 2020; 225 - 232. 10.33880/ejfm.2020090405
Vancouver Aslaner H,Aslaner H,ERTURK ARIK B,Onuk A,Benli A,Mistik S Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours. . 2020; 225 - 232. 10.33880/ejfm.2020090405
IEEE Aslaner H,Aslaner H,ERTURK ARIK B,Onuk A,Benli A,Mistik S "Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours." , ss.225 - 232, 2020. 10.33880/ejfm.2020090405
ISNAD Aslaner, Hümeyra vd. "Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours". (2020), 225-232. https://doi.org/10.33880/ejfm.2020090405
APA Aslaner H, Aslaner H, ERTURK ARIK B, Onuk A, Benli A, Mistik S (2020). Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours. Eurasian Journal of Family Medicine, 9(4), 225 - 232. 10.33880/ejfm.2020090405
Chicago Aslaner Hümeyra,Aslaner Hacı Ahmet,ERTURK ARIK BADE,Onuk Alpay,Benli Ali Ramazan,Mistik Selcuk Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours. Eurasian Journal of Family Medicine 9, no.4 (2020): 225 - 232. 10.33880/ejfm.2020090405
MLA Aslaner Hümeyra,Aslaner Hacı Ahmet,ERTURK ARIK BADE,Onuk Alpay,Benli Ali Ramazan,Mistik Selcuk Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours. Eurasian Journal of Family Medicine, vol.9, no.4, 2020, ss.225 - 232. 10.33880/ejfm.2020090405
AMA Aslaner H,Aslaner H,ERTURK ARIK B,Onuk A,Benli A,Mistik S Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours. Eurasian Journal of Family Medicine. 2020; 9(4): 225 - 232. 10.33880/ejfm.2020090405
Vancouver Aslaner H,Aslaner H,ERTURK ARIK B,Onuk A,Benli A,Mistik S Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours. Eurasian Journal of Family Medicine. 2020; 9(4): 225 - 232. 10.33880/ejfm.2020090405
IEEE Aslaner H,Aslaner H,ERTURK ARIK B,Onuk A,Benli A,Mistik S "Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours." Eurasian Journal of Family Medicine, 9, ss.225 - 232, 2020. 10.33880/ejfm.2020090405
ISNAD Aslaner, Hümeyra vd. "Rapid Antigen Detection Test Using Rates of Family Physicians, TestResults and Its Impact on Their Prescription Behaviours". Eurasian Journal of Family Medicine 9/4 (2020), 225-232. https://doi.org/10.33880/ejfm.2020090405